Location-dependent synaptic plasticity rules by dendritic spine cooperativity

Inputs to functionally related synapses have been suggested to show cooperative summation, although the rules governing these interactions are unclear. Here, Weber et al. uncover non-linear interactions dependent on NMDAR signalling that vary across the proximal-distal axis of individual dendrites.

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Detalles Bibliográficos
Autores principales: Jens P. Weber, Bertalan K. Andrásfalvy, Marina Polito, Ádám Magó, Balázs B. Ujfalussy, Judit K. Makara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/79634141d9ac4cb090ce5046b093bc28
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Sumario:Inputs to functionally related synapses have been suggested to show cooperative summation, although the rules governing these interactions are unclear. Here, Weber et al. uncover non-linear interactions dependent on NMDAR signalling that vary across the proximal-distal axis of individual dendrites.