Determinants of vitamin D status in Kenyan calves

Abstract Vitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veter...

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Autores principales:	Rebecca Callaby, Emma Hurst, Ian Handel, Phil Toye, Barend M. de C. Bronsvoort, Richard J. Mellanby
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/796a2cb18169475cbb3fbaf0f7b2a8ae
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spelling	oai:doaj.org-article:796a2cb18169475cbb3fbaf0f7b2a8ae2021-12-02T12:33:44ZDeterminants of vitamin D status in Kenyan calves10.1038/s41598-020-77209-52045-2322https://doaj.org/article/796a2cb18169475cbb3fbaf0f7b2a8ae2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77209-5https://doaj.org/toc/2045-2322Abstract Vitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veterinary species. We have previously demonstrated a relationship between vitamin D status, assessed by the measurement of serum concentrations of the major vitamin D metabolite 25 hydroxyvitamin D (25(OH)D), and a wide range of non-skeletal health outcomes in companion and wild animals. The aims of this study were to define the host and environmental factors associated with vitamin D status in a cohort of 527 calves from Western Kenya which were part of the Infectious Disease of East African Livestock (IDEAL) cohort. A secondary aim was to explore the relationship between serum 25(OH)D concentrations measured in 7-day old calves and subsequent health outcomes over the following 12 months. A genome wide association study demonstrated that both dietary and endogenously produced vitamin D metabolites were under polygenic control in African calves. In addition, we found that neonatal vitamin D status was not predictive of the subsequent development of an infectious disease event or mortality over the 12 month follow up period.Rebecca CallabyEmma HurstIan HandelPhil ToyeBarend M. de C. BronsvoortRichard J. MellanbyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rebecca Callaby Emma Hurst Ian Handel Phil Toye Barend M. de C. Bronsvoort Richard J. Mellanby Determinants of vitamin D status in Kenyan calves
description	Abstract Vitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veterinary species. We have previously demonstrated a relationship between vitamin D status, assessed by the measurement of serum concentrations of the major vitamin D metabolite 25 hydroxyvitamin D (25(OH)D), and a wide range of non-skeletal health outcomes in companion and wild animals. The aims of this study were to define the host and environmental factors associated with vitamin D status in a cohort of 527 calves from Western Kenya which were part of the Infectious Disease of East African Livestock (IDEAL) cohort. A secondary aim was to explore the relationship between serum 25(OH)D concentrations measured in 7-day old calves and subsequent health outcomes over the following 12 months. A genome wide association study demonstrated that both dietary and endogenously produced vitamin D metabolites were under polygenic control in African calves. In addition, we found that neonatal vitamin D status was not predictive of the subsequent development of an infectious disease event or mortality over the 12 month follow up period.
format	article
author	Rebecca Callaby Emma Hurst Ian Handel Phil Toye Barend M. de C. Bronsvoort Richard J. Mellanby
author_facet	Rebecca Callaby Emma Hurst Ian Handel Phil Toye Barend M. de C. Bronsvoort Richard J. Mellanby
author_sort	Rebecca Callaby
title	Determinants of vitamin D status in Kenyan calves
title_short	Determinants of vitamin D status in Kenyan calves
title_full	Determinants of vitamin D status in Kenyan calves
title_fullStr	Determinants of vitamin D status in Kenyan calves
title_full_unstemmed	Determinants of vitamin D status in Kenyan calves
title_sort	determinants of vitamin d status in kenyan calves
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/796a2cb18169475cbb3fbaf0f7b2a8ae
work_keys_str_mv	AT rebeccacallaby determinantsofvitamindstatusinkenyancalves AT emmahurst determinantsofvitamindstatusinkenyancalves AT ianhandel determinantsofvitamindstatusinkenyancalves AT philtoye determinantsofvitamindstatusinkenyancalves AT barendmdecbronsvoort determinantsofvitamindstatusinkenyancalves AT richardjmellanby determinantsofvitamindstatusinkenyancalves
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Determinants of vitamin D status in Kenyan calves

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