No evidence of inbreeding depression in a Tasmanian devil insurance population despite significant variation in inbreeding

Abstract Inbreeding depression occurs when inbred individuals experience reduced fitness as a result of reduced genome-wide heterozygosity. The Tasmanian devil faces extinction due to a contagious cancer, devil facial tumour disease (DFTD). An insurance metapopulation was established in 2006 to ensu...

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Autores principales:	Rebecca Gooley, Carolyn J. Hogg, Katherine Belov, Catherine E. Grueber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/796a8a0469974d42a74002cc7fea03d6
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spelling	oai:doaj.org-article:796a8a0469974d42a74002cc7fea03d62021-12-02T11:51:13ZNo evidence of inbreeding depression in a Tasmanian devil insurance population despite significant variation in inbreeding10.1038/s41598-017-02000-y2045-2322https://doaj.org/article/796a8a0469974d42a74002cc7fea03d62017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02000-yhttps://doaj.org/toc/2045-2322Abstract Inbreeding depression occurs when inbred individuals experience reduced fitness as a result of reduced genome-wide heterozygosity. The Tasmanian devil faces extinction due to a contagious cancer, devil facial tumour disease (DFTD). An insurance metapopulation was established in 2006 to ensure the survival of the species and to be used as a source population for re-wilding and genetic rescue. The emergence of DFTD and the rapid decline of wild devil populations have rendered the species at risk of inbreeding depression. We used 33 microsatellite loci to (1) reconstruct a pedigree for the insurance population and (2) estimate genome-wide heterozygosity for 200 individuals. Using heterozygosity-fitness correlations, we investigated the effect of heterozygosity on six diverse fitness measures (ulna length, asymmetry, weight-at-weaning, testes volume, reproductive success and survival). Despite statistically significant evidence of variation in individual inbreeding in this population, we found no associations between inbreeding and any of our six fitness measurements. We propose that the benign environment in captivity may decrease the intensity of inbreeding depression, relative to the stressful conditions in the wild. Future work will need to measure fitness of released animals to facilitate translation of this data to the broader conservation management of the species in its native range.Rebecca GooleyCarolyn J. HoggKatherine BelovCatherine E. GrueberNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rebecca Gooley Carolyn J. Hogg Katherine Belov Catherine E. Grueber No evidence of inbreeding depression in a Tasmanian devil insurance population despite significant variation in inbreeding
description	Abstract Inbreeding depression occurs when inbred individuals experience reduced fitness as a result of reduced genome-wide heterozygosity. The Tasmanian devil faces extinction due to a contagious cancer, devil facial tumour disease (DFTD). An insurance metapopulation was established in 2006 to ensure the survival of the species and to be used as a source population for re-wilding and genetic rescue. The emergence of DFTD and the rapid decline of wild devil populations have rendered the species at risk of inbreeding depression. We used 33 microsatellite loci to (1) reconstruct a pedigree for the insurance population and (2) estimate genome-wide heterozygosity for 200 individuals. Using heterozygosity-fitness correlations, we investigated the effect of heterozygosity on six diverse fitness measures (ulna length, asymmetry, weight-at-weaning, testes volume, reproductive success and survival). Despite statistically significant evidence of variation in individual inbreeding in this population, we found no associations between inbreeding and any of our six fitness measurements. We propose that the benign environment in captivity may decrease the intensity of inbreeding depression, relative to the stressful conditions in the wild. Future work will need to measure fitness of released animals to facilitate translation of this data to the broader conservation management of the species in its native range.
format	article
author	Rebecca Gooley Carolyn J. Hogg Katherine Belov Catherine E. Grueber
author_facet	Rebecca Gooley Carolyn J. Hogg Katherine Belov Catherine E. Grueber
author_sort	Rebecca Gooley
title	No evidence of inbreeding depression in a Tasmanian devil insurance population despite significant variation in inbreeding
title_short	No evidence of inbreeding depression in a Tasmanian devil insurance population despite significant variation in inbreeding
title_full	No evidence of inbreeding depression in a Tasmanian devil insurance population despite significant variation in inbreeding
title_fullStr	No evidence of inbreeding depression in a Tasmanian devil insurance population despite significant variation in inbreeding
title_full_unstemmed	No evidence of inbreeding depression in a Tasmanian devil insurance population despite significant variation in inbreeding
title_sort	no evidence of inbreeding depression in a tasmanian devil insurance population despite significant variation in inbreeding
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/796a8a0469974d42a74002cc7fea03d6
work_keys_str_mv	AT rebeccagooley noevidenceofinbreedingdepressioninatasmaniandevilinsurancepopulationdespitesignificantvariationininbreeding AT carolynjhogg noevidenceofinbreedingdepressioninatasmaniandevilinsurancepopulationdespitesignificantvariationininbreeding AT katherinebelov noevidenceofinbreedingdepressioninatasmaniandevilinsurancepopulationdespitesignificantvariationininbreeding AT catherineegrueber noevidenceofinbreedingdepressioninatasmaniandevilinsurancepopulationdespitesignificantvariationininbreeding
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No evidence of inbreeding depression in a Tasmanian devil insurance population despite significant variation in inbreeding

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