Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

Cell migration through micrometric constraints is limited by low deformability of the nucleus. Here the authors show that in dendritic cells a perinuclear actin network nucleated by Arp2/3 increases nuclear deformation and allows the cells to pass through narrow constrictions, likely by rupturing th...

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Autores principales:	Hawa-Racine Thiam, Pablo Vargas, Nicolas Carpi, Carolina Lage Crespo, Matthew Raab, Emmanuel Terriac, Megan C. King, Jordan Jacobelli, Arthur S. Alberts, Theresia Stradal, Ana-Maria Lennon-Dumenil, Matthieu Piel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/796be198360b48fbb790124ac2cd0cd1
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spelling	oai:doaj.org-article:796be198360b48fbb790124ac2cd0cd12021-12-02T17:33:10ZPerinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments10.1038/ncomms109972041-1723https://doaj.org/article/796be198360b48fbb790124ac2cd0cd12016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10997https://doaj.org/toc/2041-1723Cell migration through micrometric constraints is limited by low deformability of the nucleus. Here the authors show that in dendritic cells a perinuclear actin network nucleated by Arp2/3 increases nuclear deformation and allows the cells to pass through narrow constrictions, likely by rupturing the nuclear lamina.Hawa-Racine ThiamPablo VargasNicolas CarpiCarolina Lage CrespoMatthew RaabEmmanuel TerriacMegan C. KingJordan JacobelliArthur S. AlbertsTheresia StradalAna-Maria Lennon-DumenilMatthieu PielNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hawa-Racine Thiam Pablo Vargas Nicolas Carpi Carolina Lage Crespo Matthew Raab Emmanuel Terriac Megan C. King Jordan Jacobelli Arthur S. Alberts Theresia Stradal Ana-Maria Lennon-Dumenil Matthieu Piel Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments
description	Cell migration through micrometric constraints is limited by low deformability of the nucleus. Here the authors show that in dendritic cells a perinuclear actin network nucleated by Arp2/3 increases nuclear deformation and allows the cells to pass through narrow constrictions, likely by rupturing the nuclear lamina.
format	article
author	Hawa-Racine Thiam Pablo Vargas Nicolas Carpi Carolina Lage Crespo Matthew Raab Emmanuel Terriac Megan C. King Jordan Jacobelli Arthur S. Alberts Theresia Stradal Ana-Maria Lennon-Dumenil Matthieu Piel
author_facet	Hawa-Racine Thiam Pablo Vargas Nicolas Carpi Carolina Lage Crespo Matthew Raab Emmanuel Terriac Megan C. King Jordan Jacobelli Arthur S. Alberts Theresia Stradal Ana-Maria Lennon-Dumenil Matthieu Piel
author_sort	Hawa-Racine Thiam
title	Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments
title_short	Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments
title_full	Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments
title_fullStr	Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments
title_full_unstemmed	Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments
title_sort	perinuclear arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/796be198360b48fbb790124ac2cd0cd1
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Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

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