Alteration of the gut fecal microbiome in children living with HIV on antiretroviral therapy in Yaounde, Cameroon
Abstract Multiple factors, such as immune disruption, prophylactic co-trimoxazole, and antiretroviral therapy, may influence the structure and function of the gut microbiome of children infected with HIV from birth. In order to understand whether HIV infection altered gut microbiome and to relate ch...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/796e894e4eee4de5896ec210e2f21eae |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:796e894e4eee4de5896ec210e2f21eae |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:796e894e4eee4de5896ec210e2f21eae2021-12-02T18:15:33ZAlteration of the gut fecal microbiome in children living with HIV on antiretroviral therapy in Yaounde, Cameroon10.1038/s41598-021-87368-82045-2322https://doaj.org/article/796e894e4eee4de5896ec210e2f21eae2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87368-8https://doaj.org/toc/2045-2322Abstract Multiple factors, such as immune disruption, prophylactic co-trimoxazole, and antiretroviral therapy, may influence the structure and function of the gut microbiome of children infected with HIV from birth. In order to understand whether HIV infection altered gut microbiome and to relate changes in microbiome structure and function to immune status, virological response and pediatric ART regimens, we characterized the gut microbiome of 87 HIV-infected and 82 non-exposed HIV-negative children from Yaounde, a cosmopolitan city in Cameroon. We found that children living with HIV had significantly lower alpha diversity in their gut microbiome and altered beta diversity that may not be related to CD4+ T cell count or viral load. There was an increased level of Akkermansia and Faecalibacterium genera and decreased level of Escherichia and other Gamma proteobacteria in children infected with HIV, among other differences. We noted an effect of ethnicity/geography on observed gut microbiome composition and that children on ritonavir-boosted protease inhibitor (PI/r)-based ART had gut microbiome composition that diverged more from HIV-negative controls compared to those on non-nucleoside reverse-transcriptase inhibitors-based ART. Further studies investigating the role of this altered gut microbiome in increased disease susceptibility are warranted for individuals who acquired HIV via mother-to-child transmission.William Baiye AbangeCasey MartinAubin Joseph NanfackLaeticia Grace YatchouNichole NusbacherClement Assob NguediaHortense Gonsu KamgaJoseph FokamSean P. KennedyAlexis NdjoloCatherine LozuponeCeline Nguefeu NkenfouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q William Baiye Abange Casey Martin Aubin Joseph Nanfack Laeticia Grace Yatchou Nichole Nusbacher Clement Assob Nguedia Hortense Gonsu Kamga Joseph Fokam Sean P. Kennedy Alexis Ndjolo Catherine Lozupone Celine Nguefeu Nkenfou Alteration of the gut fecal microbiome in children living with HIV on antiretroviral therapy in Yaounde, Cameroon |
| description |
Abstract Multiple factors, such as immune disruption, prophylactic co-trimoxazole, and antiretroviral therapy, may influence the structure and function of the gut microbiome of children infected with HIV from birth. In order to understand whether HIV infection altered gut microbiome and to relate changes in microbiome structure and function to immune status, virological response and pediatric ART regimens, we characterized the gut microbiome of 87 HIV-infected and 82 non-exposed HIV-negative children from Yaounde, a cosmopolitan city in Cameroon. We found that children living with HIV had significantly lower alpha diversity in their gut microbiome and altered beta diversity that may not be related to CD4+ T cell count or viral load. There was an increased level of Akkermansia and Faecalibacterium genera and decreased level of Escherichia and other Gamma proteobacteria in children infected with HIV, among other differences. We noted an effect of ethnicity/geography on observed gut microbiome composition and that children on ritonavir-boosted protease inhibitor (PI/r)-based ART had gut microbiome composition that diverged more from HIV-negative controls compared to those on non-nucleoside reverse-transcriptase inhibitors-based ART. Further studies investigating the role of this altered gut microbiome in increased disease susceptibility are warranted for individuals who acquired HIV via mother-to-child transmission. |
| format |
article |
| author |
William Baiye Abange Casey Martin Aubin Joseph Nanfack Laeticia Grace Yatchou Nichole Nusbacher Clement Assob Nguedia Hortense Gonsu Kamga Joseph Fokam Sean P. Kennedy Alexis Ndjolo Catherine Lozupone Celine Nguefeu Nkenfou |
| author_facet |
William Baiye Abange Casey Martin Aubin Joseph Nanfack Laeticia Grace Yatchou Nichole Nusbacher Clement Assob Nguedia Hortense Gonsu Kamga Joseph Fokam Sean P. Kennedy Alexis Ndjolo Catherine Lozupone Celine Nguefeu Nkenfou |
| author_sort |
William Baiye Abange |
| title |
Alteration of the gut fecal microbiome in children living with HIV on antiretroviral therapy in Yaounde, Cameroon |
| title_short |
Alteration of the gut fecal microbiome in children living with HIV on antiretroviral therapy in Yaounde, Cameroon |
| title_full |
Alteration of the gut fecal microbiome in children living with HIV on antiretroviral therapy in Yaounde, Cameroon |
| title_fullStr |
Alteration of the gut fecal microbiome in children living with HIV on antiretroviral therapy in Yaounde, Cameroon |
| title_full_unstemmed |
Alteration of the gut fecal microbiome in children living with HIV on antiretroviral therapy in Yaounde, Cameroon |
| title_sort |
alteration of the gut fecal microbiome in children living with hiv on antiretroviral therapy in yaounde, cameroon |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/796e894e4eee4de5896ec210e2f21eae |
| work_keys_str_mv |
AT williambaiyeabange alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon AT caseymartin alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon AT aubinjosephnanfack alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon AT laeticiagraceyatchou alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon AT nicholenusbacher alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon AT clementassobnguedia alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon AT hortensegonsukamga alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon AT josephfokam alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon AT seanpkennedy alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon AT alexisndjolo alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon AT catherinelozupone alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon AT celinenguefeunkenfou alterationofthegutfecalmicrobiomeinchildrenlivingwithhivonantiretroviraltherapyinyaoundecameroon |
| _version_ |
1718378341348671488 |