Segmental Alterations of the Corpus Callosum in Progressive Supranuclear Palsy: A Multiparametric Magnetic Resonance Imaging Study

Background: The regional distribution of the widespread cerebral morphological alterations in progressive supranuclear palsy (PSP) is considered to include segmental parts of the corpus callosum (CC).Objective: The study was designed to investigate the regional white matter (WM) of the CC by T1 weig...

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Autores principales:	Lavinia A. Bârlescu, Hans-Peter Müller, Ingo Uttner, Albert C. Ludolph, Elmar H. Pinkhardt, Hans-Jürgen Huppertz, Jan Kassubek
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	progressive supranuclear palsy corpus callosum magnetic resonance imaging diffusion tensor imaging texture analysis fiber tracking Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/796ee4bd5f5b4643b6d62285fc590238
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spelling	oai:doaj.org-article:796ee4bd5f5b4643b6d62285fc5902382021-11-19T07:53:23ZSegmental Alterations of the Corpus Callosum in Progressive Supranuclear Palsy: A Multiparametric Magnetic Resonance Imaging Study1663-436510.3389/fnagi.2021.720634https://doaj.org/article/796ee4bd5f5b4643b6d62285fc5902382021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.720634/fullhttps://doaj.org/toc/1663-4365Background: The regional distribution of the widespread cerebral morphological alterations in progressive supranuclear palsy (PSP) is considered to include segmental parts of the corpus callosum (CC).Objective: The study was designed to investigate the regional white matter (WM) of the CC by T1 weighted magnetic resonance imaging (T1w MRI) data combined with diffusion tensor imaging (DTI) data in PSP patients, differentiated in the variants Richardson syndrome and PSP-parkinsonism, and to compare them with Parkinson’s Disease (PD) patients and healthy controls, in order to identify macro- and micro-structural alterations in vivo.Methods: MRI-based WM mapping was used to perform an operator-independent segmentation for the different CC segments in 66 PSP patients vs. 66 PD patients vs. 44 matched healthy controls. The segmentation was followed by both planimetric and texture analysis of the separated CC areas for the comparison of the three groups. Results were complemented by a DTI-based tract-of-interest analysis of the associated callosal tracts.Results: Significant alterations of the parameters entropy and homogeneity compared to controls were observed for PSP as well as for PD for the CC areas I, II, and III. The inhomogeneity in area II in the PSP cohort was the highest and differed significantly from PD. A combined score was defined as a potential marker for the different types of neurodegenerative parkinsonism; receiver operating characteristics (ROC) curves were calculated with areas under the curve values of 0.86 for PSP vs. controls, 0.72 for PD vs. controls, and 0.69 for PSP vs. PD, respectively.Conclusion: The multiparametric MRI texture and DTI analysis demonstrated extensive alterations of the frontal CC in neurodegenerative parkinsonism, whereas regional CC atrophy cannot be regarded as a constant neuroimaging feature of PSP. Specifically, the comparison PSP vs. PD revealed significant alterations in callosal area II. The combination of the texture and the DTI parameters might contribute as a neuroimaging marker for the assessment of the CC in PSP, including the differentiation vs. PD.Lavinia A. BârlescuHans-Peter MüllerIngo UttnerAlbert C. LudolphAlbert C. LudolphElmar H. PinkhardtHans-Jürgen HuppertzJan KassubekJan KassubekFrontiers Media S.A.articleprogressive supranuclear palsycorpus callosummagnetic resonance imagingdiffusion tensor imagingtexture analysisfiber trackingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	progressive supranuclear palsy corpus callosum magnetic resonance imaging diffusion tensor imaging texture analysis fiber tracking Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	progressive supranuclear palsy corpus callosum magnetic resonance imaging diffusion tensor imaging texture analysis fiber tracking Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Lavinia A. Bârlescu Hans-Peter Müller Ingo Uttner Albert C. Ludolph Albert C. Ludolph Elmar H. Pinkhardt Hans-Jürgen Huppertz Jan Kassubek Jan Kassubek Segmental Alterations of the Corpus Callosum in Progressive Supranuclear Palsy: A Multiparametric Magnetic Resonance Imaging Study
description	Background: The regional distribution of the widespread cerebral morphological alterations in progressive supranuclear palsy (PSP) is considered to include segmental parts of the corpus callosum (CC).Objective: The study was designed to investigate the regional white matter (WM) of the CC by T1 weighted magnetic resonance imaging (T1w MRI) data combined with diffusion tensor imaging (DTI) data in PSP patients, differentiated in the variants Richardson syndrome and PSP-parkinsonism, and to compare them with Parkinson’s Disease (PD) patients and healthy controls, in order to identify macro- and micro-structural alterations in vivo.Methods: MRI-based WM mapping was used to perform an operator-independent segmentation for the different CC segments in 66 PSP patients vs. 66 PD patients vs. 44 matched healthy controls. The segmentation was followed by both planimetric and texture analysis of the separated CC areas for the comparison of the three groups. Results were complemented by a DTI-based tract-of-interest analysis of the associated callosal tracts.Results: Significant alterations of the parameters entropy and homogeneity compared to controls were observed for PSP as well as for PD for the CC areas I, II, and III. The inhomogeneity in area II in the PSP cohort was the highest and differed significantly from PD. A combined score was defined as a potential marker for the different types of neurodegenerative parkinsonism; receiver operating characteristics (ROC) curves were calculated with areas under the curve values of 0.86 for PSP vs. controls, 0.72 for PD vs. controls, and 0.69 for PSP vs. PD, respectively.Conclusion: The multiparametric MRI texture and DTI analysis demonstrated extensive alterations of the frontal CC in neurodegenerative parkinsonism, whereas regional CC atrophy cannot be regarded as a constant neuroimaging feature of PSP. Specifically, the comparison PSP vs. PD revealed significant alterations in callosal area II. The combination of the texture and the DTI parameters might contribute as a neuroimaging marker for the assessment of the CC in PSP, including the differentiation vs. PD.
format	article
author	Lavinia A. Bârlescu Hans-Peter Müller Ingo Uttner Albert C. Ludolph Albert C. Ludolph Elmar H. Pinkhardt Hans-Jürgen Huppertz Jan Kassubek Jan Kassubek
author_facet	Lavinia A. Bârlescu Hans-Peter Müller Ingo Uttner Albert C. Ludolph Albert C. Ludolph Elmar H. Pinkhardt Hans-Jürgen Huppertz Jan Kassubek Jan Kassubek
author_sort	Lavinia A. Bârlescu
title	Segmental Alterations of the Corpus Callosum in Progressive Supranuclear Palsy: A Multiparametric Magnetic Resonance Imaging Study
title_short	Segmental Alterations of the Corpus Callosum in Progressive Supranuclear Palsy: A Multiparametric Magnetic Resonance Imaging Study
title_full	Segmental Alterations of the Corpus Callosum in Progressive Supranuclear Palsy: A Multiparametric Magnetic Resonance Imaging Study
title_fullStr	Segmental Alterations of the Corpus Callosum in Progressive Supranuclear Palsy: A Multiparametric Magnetic Resonance Imaging Study
title_full_unstemmed	Segmental Alterations of the Corpus Callosum in Progressive Supranuclear Palsy: A Multiparametric Magnetic Resonance Imaging Study
title_sort	segmental alterations of the corpus callosum in progressive supranuclear palsy: a multiparametric magnetic resonance imaging study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/796ee4bd5f5b4643b6d62285fc590238
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Segmental Alterations of the Corpus Callosum in Progressive Supranuclear Palsy: A Multiparametric Magnetic Resonance Imaging Study

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