The Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial

Background: A new sweetener with the commercial name of Lacritose has been recently produced, which is a combination of four simple sugars (lactose, fructose, sucrose, erythritol), with specific ingredients and percentages. This study aimed to assess glycemic response and short term gastrointestinal...

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Autores principales:	Masoud Rahmanian, Zohre Mozafari, Danial Chaleshi, Marzieh Shukohifar, Saeedeh Jam-Ashkezari
Formato:	article
Lenguaje:	EN
Publicado:	Shahid Sadoughi University of Medical Sciences and Health Services 2021
Materias:	diabetes lactose sugars sweeteners blood glucose control Agriculture S Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/797299719603416780ef7e5d562f5bf2
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spelling	oai:doaj.org-article:797299719603416780ef7e5d562f5bf22021-11-03T17:02:28ZThe Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial2476-74172476-7425https://doaj.org/article/797299719603416780ef7e5d562f5bf22021-11-01T00:00:00Zhttp://jnfs.ssu.ac.ir/article-1-365-en.htmlhttps://doaj.org/toc/2476-7417https://doaj.org/toc/2476-7425Background: A new sweetener with the commercial name of Lacritose has been recently produced, which is a combination of four simple sugars (lactose, fructose, sucrose, erythritol), with specific ingredients and percentages. This study aimed to assess glycemic response and short term gastrointestinal reactions in type 2 diabetic patients. Methods: In this triple-blind randomized clinical trial, 30 diabetic patients referred to Yazd Diabetes Research Center in 2018 were included. After collecting the primary data, they were assigned into three groups, including sucrose consumers as the control group, sucrose-lactose, and lacritose as the groups of consumers group. They were followed for two weeks, and fasting blood glucose (FBG), 2-hour postprandial test (2HPP), fructose amine, SGOT, SGPT, urea, creatinine, and insulin resistance index (HOMA-IR) were assessed. Results: In lacritose consumers, significant reductions were seen in FBG and 2HPP (P < 0.001 and P = 0.05, respectively), although changes among the groups were not significant. In sucrose-lacritose consumers, FBG and cholesterol levels decreased (P = 0.04 and P = 0.03, respectively). In sucrose consumers, no reduction was seen. HOMA-IR did not significantly decrease, but intergroup changes were obvious. Conclusion: The lacritose effects on FBG and 2HPP were significantly evident, but the other metabolic indices did not show any significant change.Masoud RahmanianZohre MozafariDanial ChaleshiMarzieh ShukohifarSaeedeh Jam-AshkezariShahid Sadoughi University of Medical Sciences and Health Servicesarticlediabeteslactosesugarssweetenersblood glucose controlAgricultureSNutrition. Foods and food supplyTX341-641ENJournal of Nutrition and Food Security, Vol 6, Iss 4, Pp 360-366 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes lactose sugars sweeteners blood glucose control Agriculture S Nutrition. Foods and food supply TX341-641
spellingShingle	diabetes lactose sugars sweeteners blood glucose control Agriculture S Nutrition. Foods and food supply TX341-641 Masoud Rahmanian Zohre Mozafari Danial Chaleshi Marzieh Shukohifar Saeedeh Jam-Ashkezari The Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial
description	Background: A new sweetener with the commercial name of Lacritose has been recently produced, which is a combination of four simple sugars (lactose, fructose, sucrose, erythritol), with specific ingredients and percentages. This study aimed to assess glycemic response and short term gastrointestinal reactions in type 2 diabetic patients. Methods: In this triple-blind randomized clinical trial, 30 diabetic patients referred to Yazd Diabetes Research Center in 2018 were included. After collecting the primary data, they were assigned into three groups, including sucrose consumers as the control group, sucrose-lactose, and lacritose as the groups of consumers group. They were followed for two weeks, and fasting blood glucose (FBG), 2-hour postprandial test (2HPP), fructose amine, SGOT, SGPT, urea, creatinine, and insulin resistance index (HOMA-IR) were assessed. Results: In lacritose consumers, significant reductions were seen in FBG and 2HPP (P < 0.001 and P = 0.05, respectively), although changes among the groups were not significant. In sucrose-lacritose consumers, FBG and cholesterol levels decreased (P = 0.04 and P = 0.03, respectively). In sucrose consumers, no reduction was seen. HOMA-IR did not significantly decrease, but intergroup changes were obvious. Conclusion: The lacritose effects on FBG and 2HPP were significantly evident, but the other metabolic indices did not show any significant change.
format	article
author	Masoud Rahmanian Zohre Mozafari Danial Chaleshi Marzieh Shukohifar Saeedeh Jam-Ashkezari
author_facet	Masoud Rahmanian Zohre Mozafari Danial Chaleshi Marzieh Shukohifar Saeedeh Jam-Ashkezari
author_sort	Masoud Rahmanian
title	The Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial
title_short	The Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial
title_full	The Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial
title_fullStr	The Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial
title_full_unstemmed	The Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial
title_sort	effect of a new mixture of sugar and sugar-alcohol (lacritose) on blood glucose and lipids and the possible adverse reactions in patients with type 2 diabetes: a triple-blind randomized clinical trial
publisher	Shahid Sadoughi University of Medical Sciences and Health Services
publishDate	2021
url	https://doaj.org/article/797299719603416780ef7e5d562f5bf2
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The Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial

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