LncRNA AK023948 is a positive regulator of AKT

The function of many human long non-coding RNAs (lncRNAs) is still undetermined. Here, the authors setup a gain of function CRISPR-based screen and identify a lncRNA that positively regulates AKT activity by interacting with the RNA helicase DHX9 resulting in stabilization of PI3K regulatory subunit...

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Autores principales:	Pratirodh Koirala, Jianguo Huang, Tsui-Ting Ho, Fangting Wu, Xianfeng Ding, Yin-Yuan Mo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79733fb316b948ea870d4afb62415e88
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id	oai:doaj.org-article:79733fb316b948ea870d4afb62415e88
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spelling	oai:doaj.org-article:79733fb316b948ea870d4afb62415e882021-12-02T14:42:18ZLncRNA AK023948 is a positive regulator of AKT10.1038/ncomms144222041-1723https://doaj.org/article/79733fb316b948ea870d4afb62415e882017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14422https://doaj.org/toc/2041-1723The function of many human long non-coding RNAs (lncRNAs) is still undetermined. Here, the authors setup a gain of function CRISPR-based screen and identify a lncRNA that positively regulates AKT activity by interacting with the RNA helicase DHX9 resulting in stabilization of PI3K regulatory subunit p85.Pratirodh KoiralaJianguo HuangTsui-Ting HoFangting WuXianfeng DingYin-Yuan MoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pratirodh Koirala Jianguo Huang Tsui-Ting Ho Fangting Wu Xianfeng Ding Yin-Yuan Mo LncRNA AK023948 is a positive regulator of AKT
description	The function of many human long non-coding RNAs (lncRNAs) is still undetermined. Here, the authors setup a gain of function CRISPR-based screen and identify a lncRNA that positively regulates AKT activity by interacting with the RNA helicase DHX9 resulting in stabilization of PI3K regulatory subunit p85.
format	article
author	Pratirodh Koirala Jianguo Huang Tsui-Ting Ho Fangting Wu Xianfeng Ding Yin-Yuan Mo
author_facet	Pratirodh Koirala Jianguo Huang Tsui-Ting Ho Fangting Wu Xianfeng Ding Yin-Yuan Mo
author_sort	Pratirodh Koirala
title	LncRNA AK023948 is a positive regulator of AKT
title_short	LncRNA AK023948 is a positive regulator of AKT
title_full	LncRNA AK023948 is a positive regulator of AKT
title_fullStr	LncRNA AK023948 is a positive regulator of AKT
title_full_unstemmed	LncRNA AK023948 is a positive regulator of AKT
title_sort	lncrna ak023948 is a positive regulator of akt
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/79733fb316b948ea870d4afb62415e88
work_keys_str_mv	AT pratirodhkoirala lncrnaak023948isapositiveregulatorofakt AT jianguohuang lncrnaak023948isapositiveregulatorofakt AT tsuitingho lncrnaak023948isapositiveregulatorofakt AT fangtingwu lncrnaak023948isapositiveregulatorofakt AT xianfengding lncrnaak023948isapositiveregulatorofakt AT yinyuanmo lncrnaak023948isapositiveregulatorofakt
_version_	1718389758701338624

LncRNA AK023948 is a positive regulator of AKT

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