HLA class I restriction as a possible driving force for Chikungunya evolution.

After two decades of quiescence, epidemic resurgence of Chikungunya fever (CHIKF) was reported in Africa, several islands in the Indian Ocean, South-East Asia and the Pacific causing unprecedented morbidity with some cases of fatality. Early phylogenetic analyses based on partial sequences of Chikun...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Joo Chuan Tong, Diane Simarmata, Raymond T P Lin, Laurent Rénia, Lisa F P Ng
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
R
Q
Acceso en línea:https://doaj.org/article/7975375f4d7e4b4c995d49d9d4798fec
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:7975375f4d7e4b4c995d49d9d4798fec
record_format dspace
spelling oai:doaj.org-article:7975375f4d7e4b4c995d49d9d4798fec2021-11-25T06:25:32ZHLA class I restriction as a possible driving force for Chikungunya evolution.1932-620310.1371/journal.pone.0009291https://doaj.org/article/7975375f4d7e4b4c995d49d9d4798fec2010-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20195467/?tool=EBIhttps://doaj.org/toc/1932-6203After two decades of quiescence, epidemic resurgence of Chikungunya fever (CHIKF) was reported in Africa, several islands in the Indian Ocean, South-East Asia and the Pacific causing unprecedented morbidity with some cases of fatality. Early phylogenetic analyses based on partial sequences of Chikungunya virus (CHIKV) have led to speculation that the virus behind recent epidemics may result in greater pathogenicity. To understand the reasons for these new epidemics, we first performed extensive analyses of existing CHIKV sequences from its introduction in 1952 to 2009. Our results revealed the existence of a continuous genotypic lineage, suggesting selective pressure is active in CHIKV evolution. We further showed that CHIKV is undergoing mild positive selection, and that site-specific mutations may be driven by cell-mediated immune pressure, with occasional changes that resulted in the loss of human leukocyte antigen (HLA) class I-restricting elements. These findings provide a basis to understand Chikungunya virus evolution and reveal the power of post-genomic analyses to understand CHIKV and other viral epidemiology. Such an approach is useful for studying the impact of host immunity on pathogen evolution, and may help identify appropriate antigens suitable for subunit vaccine formulations.Joo Chuan TongDiane SimarmataRaymond T P LinLaurent RéniaLisa F P NgPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 2, p e9291 (2010)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Joo Chuan Tong
Diane Simarmata
Raymond T P Lin
Laurent Rénia
Lisa F P Ng
HLA class I restriction as a possible driving force for Chikungunya evolution.
description After two decades of quiescence, epidemic resurgence of Chikungunya fever (CHIKF) was reported in Africa, several islands in the Indian Ocean, South-East Asia and the Pacific causing unprecedented morbidity with some cases of fatality. Early phylogenetic analyses based on partial sequences of Chikungunya virus (CHIKV) have led to speculation that the virus behind recent epidemics may result in greater pathogenicity. To understand the reasons for these new epidemics, we first performed extensive analyses of existing CHIKV sequences from its introduction in 1952 to 2009. Our results revealed the existence of a continuous genotypic lineage, suggesting selective pressure is active in CHIKV evolution. We further showed that CHIKV is undergoing mild positive selection, and that site-specific mutations may be driven by cell-mediated immune pressure, with occasional changes that resulted in the loss of human leukocyte antigen (HLA) class I-restricting elements. These findings provide a basis to understand Chikungunya virus evolution and reveal the power of post-genomic analyses to understand CHIKV and other viral epidemiology. Such an approach is useful for studying the impact of host immunity on pathogen evolution, and may help identify appropriate antigens suitable for subunit vaccine formulations.
format article
author Joo Chuan Tong
Diane Simarmata
Raymond T P Lin
Laurent Rénia
Lisa F P Ng
author_facet Joo Chuan Tong
Diane Simarmata
Raymond T P Lin
Laurent Rénia
Lisa F P Ng
author_sort Joo Chuan Tong
title HLA class I restriction as a possible driving force for Chikungunya evolution.
title_short HLA class I restriction as a possible driving force for Chikungunya evolution.
title_full HLA class I restriction as a possible driving force for Chikungunya evolution.
title_fullStr HLA class I restriction as a possible driving force for Chikungunya evolution.
title_full_unstemmed HLA class I restriction as a possible driving force for Chikungunya evolution.
title_sort hla class i restriction as a possible driving force for chikungunya evolution.
publisher Public Library of Science (PLoS)
publishDate 2010
url https://doaj.org/article/7975375f4d7e4b4c995d49d9d4798fec
work_keys_str_mv AT joochuantong hlaclassirestrictionasapossibledrivingforceforchikungunyaevolution
AT dianesimarmata hlaclassirestrictionasapossibledrivingforceforchikungunyaevolution
AT raymondtplin hlaclassirestrictionasapossibledrivingforceforchikungunyaevolution
AT laurentrenia hlaclassirestrictionasapossibledrivingforceforchikungunyaevolution
AT lisafpng hlaclassirestrictionasapossibledrivingforceforchikungunyaevolution
_version_ 1718413752291819520