Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics

Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are thought to transmit to humans via wild mammals, especially bats. However, evidence for direct bat-to-human transmission is lacking. Involvement of intermediate hosts is considered a reason for SARS-CoV-2 transmissio...

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Autores principales:	Luciano Rodrigo Lopes, Giancarlo de Mattos Cardillo, Natália Carvalho de Lucca Pina, Antonio Carlos da Silva Junior, Silvana Kertzer Kasinski, Paulo Bandiera-Paiva
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	SARS-CoV-2 Angiotensin-converting enzyme 2 Coronavirus Brazilian mammals White-tailed deer Veterinary medicine SF600-1100 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/7978077d45164c2b8b809ca894425072
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id	oai:doaj.org-article:7978077d45164c2b8b809ca894425072
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spelling	oai:doaj.org-article:7978077d45164c2b8b809ca8944250722021-11-14T12:06:11ZPrediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics10.1186/s44149-021-00020-w2731-0442https://doaj.org/article/7978077d45164c2b8b809ca8944250722021-09-01T00:00:00Zhttps://doi.org/10.1186/s44149-021-00020-whttps://doaj.org/toc/2731-0442Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are thought to transmit to humans via wild mammals, especially bats. However, evidence for direct bat-to-human transmission is lacking. Involvement of intermediate hosts is considered a reason for SARS-CoV-2 transmission to humans and emergence of outbreak. Large biodiversity is found in tropical territories, such as Brazil. On the similar line, this study aimed to predict potential coronavirus hosts among Brazilian wild mammals based on angiotensin-converting enzyme 2 (ACE2) sequences using evolutionary bioinformatics. Cougar, maned wolf, and bush dogs were predicted as potential hosts for coronavirus. These indigenous carnivores are philogenetically closer to the known SARS-CoV/SARS-CoV-2 hosts and presented low ACE2 divergence. A new coronavirus transmission chain was developed in which white-tailed deer, a susceptible SARS-CoV-2 host, have the central position. Cougar play an important role because of its low divergent ACE2 level in deer and humans. The discovery of these potential coronavirus hosts will be useful for epidemiological surveillance and discovery of interventions that can contribute to break the transmission chain.Luciano Rodrigo LopesGiancarlo de Mattos CardilloNatália Carvalho de Lucca PinaAntonio Carlos da Silva JuniorSilvana Kertzer KasinskiPaulo Bandiera-PaivaBMCarticleSARS-CoV-2Angiotensin-converting enzyme 2CoronavirusBrazilian mammalsWhite-tailed deerVeterinary medicineSF600-1100Public aspects of medicineRA1-1270ENAnimal Diseases, Vol 1, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 Angiotensin-converting enzyme 2 Coronavirus Brazilian mammals White-tailed deer Veterinary medicine SF600-1100 Public aspects of medicine RA1-1270
spellingShingle	SARS-CoV-2 Angiotensin-converting enzyme 2 Coronavirus Brazilian mammals White-tailed deer Veterinary medicine SF600-1100 Public aspects of medicine RA1-1270 Luciano Rodrigo Lopes Giancarlo de Mattos Cardillo Natália Carvalho de Lucca Pina Antonio Carlos da Silva Junior Silvana Kertzer Kasinski Paulo Bandiera-Paiva Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics
description	Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are thought to transmit to humans via wild mammals, especially bats. However, evidence for direct bat-to-human transmission is lacking. Involvement of intermediate hosts is considered a reason for SARS-CoV-2 transmission to humans and emergence of outbreak. Large biodiversity is found in tropical territories, such as Brazil. On the similar line, this study aimed to predict potential coronavirus hosts among Brazilian wild mammals based on angiotensin-converting enzyme 2 (ACE2) sequences using evolutionary bioinformatics. Cougar, maned wolf, and bush dogs were predicted as potential hosts for coronavirus. These indigenous carnivores are philogenetically closer to the known SARS-CoV/SARS-CoV-2 hosts and presented low ACE2 divergence. A new coronavirus transmission chain was developed in which white-tailed deer, a susceptible SARS-CoV-2 host, have the central position. Cougar play an important role because of its low divergent ACE2 level in deer and humans. The discovery of these potential coronavirus hosts will be useful for epidemiological surveillance and discovery of interventions that can contribute to break the transmission chain.
format	article
author	Luciano Rodrigo Lopes Giancarlo de Mattos Cardillo Natália Carvalho de Lucca Pina Antonio Carlos da Silva Junior Silvana Kertzer Kasinski Paulo Bandiera-Paiva
author_facet	Luciano Rodrigo Lopes Giancarlo de Mattos Cardillo Natália Carvalho de Lucca Pina Antonio Carlos da Silva Junior Silvana Kertzer Kasinski Paulo Bandiera-Paiva
author_sort	Luciano Rodrigo Lopes
title	Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics
title_short	Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics
title_full	Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics
title_fullStr	Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics
title_full_unstemmed	Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics
title_sort	prediction of sars-cov-2 hosts among brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics
publisher	BMC
publishDate	2021
url	https://doaj.org/article/7978077d45164c2b8b809ca894425072
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Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics

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