The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation.

Ventricular-arterial coupling is a major determinant of cardiovascular performance, however, there are still inherent difficulties in distinguishing ventricular from vascular effects on arterial pulse phenotypes. In the present study, we employed an extensive mathematical model of the cardiovascular...

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Autores principales:	Stamatia Pagoulatou, Dionysios Adamopoulos, Georgios Rovas, Vasiliki Bikia, Nikolaos Stergiopulos
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/797cb6e69e9e4e09a6d467c1260da8f7
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spelling	oai:doaj.org-article:797cb6e69e9e4e09a6d467c1260da8f72021-12-02T20:18:51ZThe effect of left ventricular contractility on arterial hemodynamics: A model-based investigation.1932-620310.1371/journal.pone.0255561https://doaj.org/article/797cb6e69e9e4e09a6d467c1260da8f72021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255561https://doaj.org/toc/1932-6203Ventricular-arterial coupling is a major determinant of cardiovascular performance, however, there are still inherent difficulties in distinguishing ventricular from vascular effects on arterial pulse phenotypes. In the present study, we employed an extensive mathematical model of the cardiovascular system to investigate how sole changes in cardiac contractility might affect hemodynamics. We simulated two physiologically relevant cases of high and low contractility by altering the end-systolic elastance, Ees, (3 versus 1 mmHg/mL) under constant cardiac output and afterload, and subsequently performed pulse wave analysis and wave separation. The aortic forward pressure wave component was steeper for high Ees, which led to the change of the total pressure waveform from the characteristic Type A phenotype to Type C, and the decrease in augmentation index, AIx (-2.4% versus +18.1%). Additionally, the increase in Ees caused the pulse pressure amplification from the aorta to the radial artery to rise drastically (1.86 versus 1.39). Our results show that an increase in cardiac contractility alone, with no concomitant change in arterial properties, alters the shape of the forward pressure wave, which, consequently, changes central and peripheral pulse phenotypes. Indices based on the pressure waveform, like AIx, cannot be assumed to reflect only arterial properties.Stamatia PagoulatouDionysios AdamopoulosGeorgios RovasVasiliki BikiaNikolaos StergiopulosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255561 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stamatia Pagoulatou Dionysios Adamopoulos Georgios Rovas Vasiliki Bikia Nikolaos Stergiopulos The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation.
description	Ventricular-arterial coupling is a major determinant of cardiovascular performance, however, there are still inherent difficulties in distinguishing ventricular from vascular effects on arterial pulse phenotypes. In the present study, we employed an extensive mathematical model of the cardiovascular system to investigate how sole changes in cardiac contractility might affect hemodynamics. We simulated two physiologically relevant cases of high and low contractility by altering the end-systolic elastance, Ees, (3 versus 1 mmHg/mL) under constant cardiac output and afterload, and subsequently performed pulse wave analysis and wave separation. The aortic forward pressure wave component was steeper for high Ees, which led to the change of the total pressure waveform from the characteristic Type A phenotype to Type C, and the decrease in augmentation index, AIx (-2.4% versus +18.1%). Additionally, the increase in Ees caused the pulse pressure amplification from the aorta to the radial artery to rise drastically (1.86 versus 1.39). Our results show that an increase in cardiac contractility alone, with no concomitant change in arterial properties, alters the shape of the forward pressure wave, which, consequently, changes central and peripheral pulse phenotypes. Indices based on the pressure waveform, like AIx, cannot be assumed to reflect only arterial properties.
format	article
author	Stamatia Pagoulatou Dionysios Adamopoulos Georgios Rovas Vasiliki Bikia Nikolaos Stergiopulos
author_facet	Stamatia Pagoulatou Dionysios Adamopoulos Georgios Rovas Vasiliki Bikia Nikolaos Stergiopulos
author_sort	Stamatia Pagoulatou
title	The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation.
title_short	The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation.
title_full	The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation.
title_fullStr	The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation.
title_full_unstemmed	The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation.
title_sort	effect of left ventricular contractility on arterial hemodynamics: a model-based investigation.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/797cb6e69e9e4e09a6d467c1260da8f7
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The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation.

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