Prognostic and immunological value of LTB4R in pan-cancer

Background: LTB4 receptor 1 (LTB4R), as the high affinity leukotriene B4 receptor, is rapidly revealing its function in malignancies. However, it is still uncertain. Methods: We investigated the expression pattern and prognostic significance of LTB4R in pan-cancer across different databases, in...

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Autores principales:	Sidan Long, Shuangshuang Ji, Kunmin Xiao, Peng Xue, Shijie Zhu
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	leukotriene b4 receptor 1 pan-cancer database survival analysis immune infiltration tumor microenvironment Biotechnology TP248.13-248.65 Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/797d2980792b4ac1a054b4bad6ae1728
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spelling	oai:doaj.org-article:797d2980792b4ac1a054b4bad6ae17282021-11-29T05:59:28ZPrognostic and immunological value of LTB4R in pan-cancer10.3934/mbe.20214591551-0018https://doaj.org/article/797d2980792b4ac1a054b4bad6ae17282021-10-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021459?viewType=HTMLhttps://doaj.org/toc/1551-0018Background: LTB4 receptor 1 (LTB4R), as the high affinity leukotriene B4 receptor, is rapidly revealing its function in malignancies. However, it is still uncertain. Methods: We investigated the expression pattern and prognostic significance of LTB4R in pan-cancer across different databases, including ONCOMINE, PrognoScan, GEPIA, and Kaplan-Meier Plotter, in this study. Meanwhile, we explored the significance of LTB4R in tumor metastasis by HCMDB. Then functional enrichment analysis of related genes was performed using GeneMANIA and DAVID. Lastly, utilizing the TIMER datasets, we looked into the links between LTB4R expression and immune infiltration in malignancies. Results: In general, tumor tissue displayed higher levels of LTB4R expression than normal tissue. Although LTB4R had a negative influence on pan-cancer, a high expression level of LTB4R was protective of LIHC (liver hepatocellular carcinoma) patients' survival. There was no significant difference in the distribution of LTB4R between non-metastatic and metastatic tumors. Based on Gene Set Enrichment Analysis, LTB4R was implicated in pathways involved in inflammation, immunity, metabolism, and cancer diseases. The correlation between immune cells and LTB4R was found to be distinct across cancer types. Furthermore, markers of infiltrating immune cells, such as Treg, T cell exhaustion and T helper cells, exhibited different LTB4R-related immune infiltration patterns. Conclusion: The LTB4R is associated with immune infiltrates and can be used as a prognostic biomarker in pan-cancer.Sidan LongShuangshuang JiKunmin Xiao Peng Xue Shijie ZhuAIMS Pressarticleleukotriene b4 receptor 1pan-cancerdatabasesurvival analysisimmune infiltrationtumor microenvironmentBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 6, Pp 9336-9356 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	leukotriene b4 receptor 1 pan-cancer database survival analysis immune infiltration tumor microenvironment Biotechnology TP248.13-248.65 Mathematics QA1-939
spellingShingle	leukotriene b4 receptor 1 pan-cancer database survival analysis immune infiltration tumor microenvironment Biotechnology TP248.13-248.65 Mathematics QA1-939 Sidan Long Shuangshuang Ji Kunmin Xiao Peng Xue Shijie Zhu Prognostic and immunological value of LTB4R in pan-cancer
description	Background: LTB4 receptor 1 (LTB4R), as the high affinity leukotriene B4 receptor, is rapidly revealing its function in malignancies. However, it is still uncertain. Methods: We investigated the expression pattern and prognostic significance of LTB4R in pan-cancer across different databases, including ONCOMINE, PrognoScan, GEPIA, and Kaplan-Meier Plotter, in this study. Meanwhile, we explored the significance of LTB4R in tumor metastasis by HCMDB. Then functional enrichment analysis of related genes was performed using GeneMANIA and DAVID. Lastly, utilizing the TIMER datasets, we looked into the links between LTB4R expression and immune infiltration in malignancies. Results: In general, tumor tissue displayed higher levels of LTB4R expression than normal tissue. Although LTB4R had a negative influence on pan-cancer, a high expression level of LTB4R was protective of LIHC (liver hepatocellular carcinoma) patients' survival. There was no significant difference in the distribution of LTB4R between non-metastatic and metastatic tumors. Based on Gene Set Enrichment Analysis, LTB4R was implicated in pathways involved in inflammation, immunity, metabolism, and cancer diseases. The correlation between immune cells and LTB4R was found to be distinct across cancer types. Furthermore, markers of infiltrating immune cells, such as Treg, T cell exhaustion and T helper cells, exhibited different LTB4R-related immune infiltration patterns. Conclusion: The LTB4R is associated with immune infiltrates and can be used as a prognostic biomarker in pan-cancer.
format	article
author	Sidan Long Shuangshuang Ji Kunmin Xiao Peng Xue Shijie Zhu
author_facet	Sidan Long Shuangshuang Ji Kunmin Xiao Peng Xue Shijie Zhu
author_sort	Sidan Long
title	Prognostic and immunological value of LTB4R in pan-cancer
title_short	Prognostic and immunological value of LTB4R in pan-cancer
title_full	Prognostic and immunological value of LTB4R in pan-cancer
title_fullStr	Prognostic and immunological value of LTB4R in pan-cancer
title_full_unstemmed	Prognostic and immunological value of LTB4R in pan-cancer
title_sort	prognostic and immunological value of ltb4r in pan-cancer
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/797d2980792b4ac1a054b4bad6ae1728
work_keys_str_mv	AT sidanlong prognosticandimmunologicalvalueofltb4rinpancancer AT shuangshuangji prognosticandimmunologicalvalueofltb4rinpancancer AT kunminxiao prognosticandimmunologicalvalueofltb4rinpancancer AT pengxue prognosticandimmunologicalvalueofltb4rinpancancer AT shijiezhu prognosticandimmunologicalvalueofltb4rinpancancer
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Prognostic and immunological value of LTB4R in pan-cancer

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