Clinical spectrum and management options in Vogt–Koyanagi–Harada disease

Clinical spectrum and management options in Vogt–Koyanagi–Harada disease

Sikander AK Lodhi, JM Lokabhi Reddy, Venkataratnam Peram Department of Ophthalmology, Osmania Medical College/Sarojini Devi Eye Hospital, Hyderabad, Telangana, India Purpose: The aim of this study was to describe the clinical features, treatment options, and visual outcome of Vogt–Koyana...

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Autores principales: Lodhi SA, Reddy JM, Peram V
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Vogt-Koyanagi-Harada disease
Female
Uveitis
Triamcinolone
Azathioprine
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/797f0274369c4aaa8297bf094db5eb65
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spelling oai:doaj.org-article:797f0274369c4aaa8297bf094db5eb652021-12-02T00:10:42ZClinical spectrum and management options in Vogt–Koyanagi–Harada disease1177-5483https://doaj.org/article/797f0274369c4aaa8297bf094db5eb652017-08-01T00:00:00Zhttps://www.dovepress.com/clinical-spectrum-and-management-options-in-vogt-koyanagi-harada-disea-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Sikander AK Lodhi, JM Lokabhi Reddy, Venkataratnam Peram Department of Ophthalmology, Osmania Medical College/Sarojini Devi Eye Hospital, Hyderabad, Telangana, India Purpose: The aim of this study was to describe the clinical features, treatment options, and visual outcome of Vogt–Koyanagi–Harada (VKH) disease patients over a 9-year period.Method: A retrospective chart analysis of 32 patients with VKH, from January 2007 to December 2015, at a tertiary care government medical college eye hospital in South India.Results: A total of 32 patients were diagnosed with VKH. The mean age at diagnosis was 32.03±8.8 years. There were 24 patients (42 eyes) with acute VKH and eight patients (16 eyes) with recurrent/chronic VKH. The mean baseline best-corrected visual acuity on presentation in the acute VKH group was 5/60 (1.114±0.565) and at last follow-up it was 6/9 (0.225±0.157). Intravenous methyl prednisolone (IVMP) was administered for 3 days to all patients with acute and recurrent VKH, followed by posterior subtenon triamcinolone (40 mg/mL) and oral azathioprine.Conclusion: VKH-related uveitis is more common in the female gender in this South Indian population. Posterior uveitis is the most common initial manifestation. Initial aggressive treatment with IVMP, peribulbar long-acting corticosteroids, and immunosuppressives, avoiding side effects of systemic steroids, gives a good visual outcome without recurrences. Cases of unilateral VKH, seen in six patients, are the initial manifestations in the natural course of the disease, which if managed aggressively at the acute stage prevents recurrence in the other eye. Keywords: Vogt–Koyanagi–Harada disease, female, posterior uveitis, retinal detachment, triamcinolone, azathioprine Lodhi SAReddy JMPeram VDove Medical PressarticleVogt-Koyanagi-Harada diseaseFemaleUveitisTriamcinoloneAzathioprineOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1399-1406 (2017)
institution DOAJ
collection DOAJ
language EN
topic Vogt-Koyanagi-Harada disease
Female
Uveitis
Triamcinolone
Azathioprine
Ophthalmology
RE1-994
spellingShingle Vogt-Koyanagi-Harada disease
Female
Uveitis
Triamcinolone
Azathioprine
Ophthalmology
RE1-994
Lodhi SA
Reddy JM
Peram V
Clinical spectrum and management options in Vogt–Koyanagi–Harada disease
description Sikander AK Lodhi, JM Lokabhi Reddy, Venkataratnam Peram Department of Ophthalmology, Osmania Medical College/Sarojini Devi Eye Hospital, Hyderabad, Telangana, India Purpose: The aim of this study was to describe the clinical features, treatment options, and visual outcome of Vogt–Koyanagi–Harada (VKH) disease patients over a 9-year period.Method: A retrospective chart analysis of 32 patients with VKH, from January 2007 to December 2015, at a tertiary care government medical college eye hospital in South India.Results: A total of 32 patients were diagnosed with VKH. The mean age at diagnosis was 32.03±8.8 years. There were 24 patients (42 eyes) with acute VKH and eight patients (16 eyes) with recurrent/chronic VKH. The mean baseline best-corrected visual acuity on presentation in the acute VKH group was 5/60 (1.114±0.565) and at last follow-up it was 6/9 (0.225±0.157). Intravenous methyl prednisolone (IVMP) was administered for 3 days to all patients with acute and recurrent VKH, followed by posterior subtenon triamcinolone (40 mg/mL) and oral azathioprine.Conclusion: VKH-related uveitis is more common in the female gender in this South Indian population. Posterior uveitis is the most common initial manifestation. Initial aggressive treatment with IVMP, peribulbar long-acting corticosteroids, and immunosuppressives, avoiding side effects of systemic steroids, gives a good visual outcome without recurrences. Cases of unilateral VKH, seen in six patients, are the initial manifestations in the natural course of the disease, which if managed aggressively at the acute stage prevents recurrence in the other eye. Keywords: Vogt–Koyanagi–Harada disease, female, posterior uveitis, retinal detachment, triamcinolone, azathioprine 
format article
author Lodhi SA
Reddy JM
Peram V
author_facet Lodhi SA
Reddy JM
Peram V
author_sort Lodhi SA
title Clinical spectrum and management options in Vogt–Koyanagi–Harada disease
title_short Clinical spectrum and management options in Vogt–Koyanagi–Harada disease
title_full Clinical spectrum and management options in Vogt–Koyanagi–Harada disease
title_fullStr Clinical spectrum and management options in Vogt–Koyanagi–Harada disease
title_full_unstemmed Clinical spectrum and management options in Vogt–Koyanagi–Harada disease
title_sort clinical spectrum and management options in vogt–koyanagi–harada disease
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/797f0274369c4aaa8297bf094db5eb65
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AT peramv clinicalspectrumandmanagementoptionsinvogtndashkoyanagindashharadadisease
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