Beta synchrony for expressive language lateralizes to right hemisphere in development

Abstract A left perisylvian network is known to support language in healthy adults. Low-beta (13–23 Hz) event-related desynchrony (ERD) has been observed during verb generation, at approximately 700–1200 ms post-stimulus presentation in past studies; the signal is known to reflect increased neuronal...

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Autores principales:	Vivek V. Sharma, Jennifer Vannest, Hansel M. Greiner, Hisako Fujiwara, Jeffrey R. Tenney, Brady J. Williamson, Darren S. Kadis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/797f0dc7c2434e39b0fad362819d710a
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spelling	oai:doaj.org-article:797f0dc7c2434e39b0fad362819d710a2021-12-02T14:04:39ZBeta synchrony for expressive language lateralizes to right hemisphere in development10.1038/s41598-021-83373-z2045-2322https://doaj.org/article/797f0dc7c2434e39b0fad362819d710a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83373-zhttps://doaj.org/toc/2045-2322Abstract A left perisylvian network is known to support language in healthy adults. Low-beta (13–23 Hz) event-related desynchrony (ERD) has been observed during verb generation, at approximately 700–1200 ms post-stimulus presentation in past studies; the signal is known to reflect increased neuronal firing and metabolic demand during language production. In contrast, concurrent beta event-related synchrony (ERS) is thought to reflect neuronal inhibition but has not been well studied in the context of language. Further, while low-beta ERD for expressive language has been found to gradually shift from bilateral in childhood to left hemispheric by early adulthood, developmental lateralization of ERS has not been established. We used magnetoencephalography to study low beta ERS lateralization in a group of children and adolescents (n = 78), aged 4 to less than 19 years, who performed covert verb generation. We found that the youngest children had bilateral ERD and ERS. By adolescence, low-beta ERD was predominantly left lateralized in perisylvian cortex (i.e., Broca’s and Wernicke’s regions), while beta ERS was predominantly right lateralized. Increasing lateralization was significantly correlated to age for both ERD (Spearman’s r = 0.45, p < 0.01) and ERS (Spearman’s r = − 0.44, p < 0.01). Interestingly, while ERD lateralized in a linear manner, ERS lateralization followed a nonlinear trajectory, suggesting distinct developmental trajectories. Implications to early-age neuroplasticity and neuronal inhibition are discussed.Vivek V. SharmaJennifer VannestHansel M. GreinerHisako FujiwaraJeffrey R. TenneyBrady J. WilliamsonDarren S. KadisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vivek V. Sharma Jennifer Vannest Hansel M. Greiner Hisako Fujiwara Jeffrey R. Tenney Brady J. Williamson Darren S. Kadis Beta synchrony for expressive language lateralizes to right hemisphere in development
description	Abstract A left perisylvian network is known to support language in healthy adults. Low-beta (13–23 Hz) event-related desynchrony (ERD) has been observed during verb generation, at approximately 700–1200 ms post-stimulus presentation in past studies; the signal is known to reflect increased neuronal firing and metabolic demand during language production. In contrast, concurrent beta event-related synchrony (ERS) is thought to reflect neuronal inhibition but has not been well studied in the context of language. Further, while low-beta ERD for expressive language has been found to gradually shift from bilateral in childhood to left hemispheric by early adulthood, developmental lateralization of ERS has not been established. We used magnetoencephalography to study low beta ERS lateralization in a group of children and adolescents (n = 78), aged 4 to less than 19 years, who performed covert verb generation. We found that the youngest children had bilateral ERD and ERS. By adolescence, low-beta ERD was predominantly left lateralized in perisylvian cortex (i.e., Broca’s and Wernicke’s regions), while beta ERS was predominantly right lateralized. Increasing lateralization was significantly correlated to age for both ERD (Spearman’s r = 0.45, p < 0.01) and ERS (Spearman’s r = − 0.44, p < 0.01). Interestingly, while ERD lateralized in a linear manner, ERS lateralization followed a nonlinear trajectory, suggesting distinct developmental trajectories. Implications to early-age neuroplasticity and neuronal inhibition are discussed.
format	article
author	Vivek V. Sharma Jennifer Vannest Hansel M. Greiner Hisako Fujiwara Jeffrey R. Tenney Brady J. Williamson Darren S. Kadis
author_facet	Vivek V. Sharma Jennifer Vannest Hansel M. Greiner Hisako Fujiwara Jeffrey R. Tenney Brady J. Williamson Darren S. Kadis
author_sort	Vivek V. Sharma
title	Beta synchrony for expressive language lateralizes to right hemisphere in development
title_short	Beta synchrony for expressive language lateralizes to right hemisphere in development
title_full	Beta synchrony for expressive language lateralizes to right hemisphere in development
title_fullStr	Beta synchrony for expressive language lateralizes to right hemisphere in development
title_full_unstemmed	Beta synchrony for expressive language lateralizes to right hemisphere in development
title_sort	beta synchrony for expressive language lateralizes to right hemisphere in development
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/797f0dc7c2434e39b0fad362819d710a
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Beta synchrony for expressive language lateralizes to right hemisphere in development

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