Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.

Acinetobacter baumannii is an emerging opportunistic bacterium associated with nosocomial infections in intensive care units. The alarming increase in infections caused by A. baumannii is strongly associated with enhanced resistance to antibiotics, in particular carbapenems. This, together with the...

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Autores principales:	Danilo G Moriel, Scott A Beatson, Daniël J Wurpel, Jeffrey Lipman, Graeme R Nimmo, David L Paterson, Mark A Schembri
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7980698f8b254a4ab4fe4bf20f936e86
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spelling	oai:doaj.org-article:7980698f8b254a4ab4fe4bf20f936e862021-11-18T08:52:07ZIdentification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.1932-620310.1371/journal.pone.0077631https://doaj.org/article/7980698f8b254a4ab4fe4bf20f936e862013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24116234/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Acinetobacter baumannii is an emerging opportunistic bacterium associated with nosocomial infections in intensive care units. The alarming increase in infections caused by A. baumannii is strongly associated with enhanced resistance to antibiotics, in particular carbapenems. This, together with the lack of a licensed vaccine, has translated into significant economic, logistic and health impacts to health care facilities. In this study, we combined reverse vaccinology and proteomics to identify surface-exposed and secreted antigens from A. baumannii. Using in silico prediction tools and comparative genome analysis in combination with in vitro proteomic approaches, we identified 42 antigens that could be used as potential vaccine targets. Considering the paucity of effective antibiotics available to treat multidrug-resistant A. baumannii infections, these vaccine targets may serve as a framework for the development of a broadly protective multi-component vaccine, an outcome that would have a major impact on the burden of A. baumannii infections in intensive care units across the globe.Danilo G MorielScott A BeatsonDaniël J WurpelJeffrey LipmanGraeme R NimmoDavid L PatersonMark A SchembriPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e77631 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danilo G Moriel Scott A Beatson Daniël J Wurpel Jeffrey Lipman Graeme R Nimmo David L Paterson Mark A Schembri Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.
description	Acinetobacter baumannii is an emerging opportunistic bacterium associated with nosocomial infections in intensive care units. The alarming increase in infections caused by A. baumannii is strongly associated with enhanced resistance to antibiotics, in particular carbapenems. This, together with the lack of a licensed vaccine, has translated into significant economic, logistic and health impacts to health care facilities. In this study, we combined reverse vaccinology and proteomics to identify surface-exposed and secreted antigens from A. baumannii. Using in silico prediction tools and comparative genome analysis in combination with in vitro proteomic approaches, we identified 42 antigens that could be used as potential vaccine targets. Considering the paucity of effective antibiotics available to treat multidrug-resistant A. baumannii infections, these vaccine targets may serve as a framework for the development of a broadly protective multi-component vaccine, an outcome that would have a major impact on the burden of A. baumannii infections in intensive care units across the globe.
format	article
author	Danilo G Moriel Scott A Beatson Daniël J Wurpel Jeffrey Lipman Graeme R Nimmo David L Paterson Mark A Schembri
author_facet	Danilo G Moriel Scott A Beatson Daniël J Wurpel Jeffrey Lipman Graeme R Nimmo David L Paterson Mark A Schembri
author_sort	Danilo G Moriel
title	Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.
title_short	Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.
title_full	Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.
title_fullStr	Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.
title_full_unstemmed	Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.
title_sort	identification of novel vaccine candidates against multidrug-resistant acinetobacter baumannii.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7980698f8b254a4ab4fe4bf20f936e86
work_keys_str_mv	AT danilogmoriel identificationofnovelvaccinecandidatesagainstmultidrugresistantacinetobacterbaumannii AT scottabeatson identificationofnovelvaccinecandidatesagainstmultidrugresistantacinetobacterbaumannii AT danieljwurpel identificationofnovelvaccinecandidatesagainstmultidrugresistantacinetobacterbaumannii AT jeffreylipman identificationofnovelvaccinecandidatesagainstmultidrugresistantacinetobacterbaumannii AT graemernimmo identificationofnovelvaccinecandidatesagainstmultidrugresistantacinetobacterbaumannii AT davidlpaterson identificationofnovelvaccinecandidatesagainstmultidrugresistantacinetobacterbaumannii AT markaschembri identificationofnovelvaccinecandidatesagainstmultidrugresistantacinetobacterbaumannii
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Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.

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