Eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma

María de Guadalupe Chávez-López,1 Violeta Zúñiga-García,1 Julio Isael Pérez-Carreón,2 Arturo Avalos-Fuentes,3 Yesenia Escobar,4 Javier Camacho1 1Department of Pharmacology, Centro de Investigación y de...

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Autores principales:	Chávez-López MG, Zúñiga-García V, Pérez-Carreón JI, Avalos-Fuentes A, Escobar Y, Camacho J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Ion channels Eag1 Hepatocellular carcinoma Astemizole Diethylnitrosamine Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/79814a29c0b94e63834918170d2e7785
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spelling	oai:doaj.org-article:79814a29c0b94e63834918170d2e77852021-12-02T02:21:49ZEag1 channels as potential early-stage biomarkers of hepatocellular carcinoma1177-5491https://doaj.org/article/79814a29c0b94e63834918170d2e77852016-09-01T00:00:00Zhttps://www.dovepress.com/eag1-channels-as-potential-early-stage-biomarkers-of-hepatocellular-ca-peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491María de Guadalupe Chávez-López,1 Violeta Zúñiga-García,1 Julio Isael Pérez-Carreón,2 Arturo Avalos-Fuentes,3 Yesenia Escobar,4 Javier Camacho1 1Department of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, 2Instituto Nacional de Medicina Genómica, 3Department of Physiology, Biophysics and Neuroscience, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, 4Centro de Investigación Clínica Acelerada Sc, Mexico City, Mexico Abstract: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. HCC is usually asymptomatic at potential curative stages, and it has very poor prognosis if detected later. Thus, the identification of early biomarkers and novel therapies is essential to improve HCC patient survival. Ion channels have been proposed as potential tumor markers and therapeutic targets for several cancers including HCC. Especially, the ether à-go-go-1 (Eag1) voltage-gated potassium channel has been suggested as an early marker for HCC. Eag1 is overexpressed during HCC development from the cirrhotic and the preneoplastic lesions preceding HCC in a rat model. The channel is also overexpressed in human HCC. Astemizole has gained great interest as a potential anticancer drug because it targets several proteins involved in cancer including Eag1. Actually, in vivo studies have shown that astemizole may have clinical utility for HCC prevention and treatment. Here, we will review first some general aspects of HCC including the current biomarkers and therapies, and then we will focus on Eag1 channels as promising tools in the early diagnosis of HCC. Keywords: ion channels, Eag1, hepatocellular carcinoma, astemizole, diethylnitrosamineChávez-López MGZúñiga-García VPérez-Carreón JIAvalos-Fuentes AEscobar YCamacho JDove Medical PressarticleIon channelsEag1Hepatocellular carcinomaAstemizoleDiethylnitrosamineMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 10, Pp 139-148 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ion channels Eag1 Hepatocellular carcinoma Astemizole Diethylnitrosamine Medicine (General) R5-920
spellingShingle	Ion channels Eag1 Hepatocellular carcinoma Astemizole Diethylnitrosamine Medicine (General) R5-920 Chávez-López MG Zúñiga-García V Pérez-Carreón JI Avalos-Fuentes A Escobar Y Camacho J Eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma
description	María de Guadalupe Chávez-López,1 Violeta Zúñiga-García,1 Julio Isael Pérez-Carreón,2 Arturo Avalos-Fuentes,3 Yesenia Escobar,4 Javier Camacho1 1Department of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, 2Instituto Nacional de Medicina Genómica, 3Department of Physiology, Biophysics and Neuroscience, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, 4Centro de Investigación Clínica Acelerada Sc, Mexico City, Mexico Abstract: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. HCC is usually asymptomatic at potential curative stages, and it has very poor prognosis if detected later. Thus, the identification of early biomarkers and novel therapies is essential to improve HCC patient survival. Ion channels have been proposed as potential tumor markers and therapeutic targets for several cancers including HCC. Especially, the ether à-go-go-1 (Eag1) voltage-gated potassium channel has been suggested as an early marker for HCC. Eag1 is overexpressed during HCC development from the cirrhotic and the preneoplastic lesions preceding HCC in a rat model. The channel is also overexpressed in human HCC. Astemizole has gained great interest as a potential anticancer drug because it targets several proteins involved in cancer including Eag1. Actually, in vivo studies have shown that astemizole may have clinical utility for HCC prevention and treatment. Here, we will review first some general aspects of HCC including the current biomarkers and therapies, and then we will focus on Eag1 channels as promising tools in the early diagnosis of HCC. Keywords: ion channels, Eag1, hepatocellular carcinoma, astemizole, diethylnitrosamine
format	article
author	Chávez-López MG Zúñiga-García V Pérez-Carreón JI Avalos-Fuentes A Escobar Y Camacho J
author_facet	Chávez-López MG Zúñiga-García V Pérez-Carreón JI Avalos-Fuentes A Escobar Y Camacho J
author_sort	Chávez-López MG
title	Eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma
title_short	Eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma
title_full	Eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma
title_fullStr	Eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma
title_full_unstemmed	Eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma
title_sort	eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/79814a29c0b94e63834918170d2e7785
work_keys_str_mv	AT chavezlopezmg eag1channelsaspotentialearlystagebiomarkersofhepatocellularcarcinoma AT zunigagarciav eag1channelsaspotentialearlystagebiomarkersofhepatocellularcarcinoma AT perezcarreonji eag1channelsaspotentialearlystagebiomarkersofhepatocellularcarcinoma AT avalosfuentesa eag1channelsaspotentialearlystagebiomarkersofhepatocellularcarcinoma AT escobary eag1channelsaspotentialearlystagebiomarkersofhepatocellularcarcinoma AT camachoj eag1channelsaspotentialearlystagebiomarkersofhepatocellularcarcinoma
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Eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma

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