Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis

Changes in osmotic homeostasis alter metabolites and therefore chemical milieu of the cells. Here, the authors show that altering metabolites in E. coli also change the cellular capacity for buffering mutations that impair protein folding and influences proteostasis irrespective of molecular chapero...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kanika Verma, Kanika Saxena, Rajashekar Donaka, Aseem Chaphalkar, Manish Kumar Rai, Anurag Shukla, Zainab Zaidi, Rohan Dandage, Dhanasekaran Shanmugam, Kausik Chakraborty
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/798249b34fd54ac1bcfc784baef16d78
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:798249b34fd54ac1bcfc784baef16d78
record_format	dspace
spelling	oai:doaj.org-article:798249b34fd54ac1bcfc784baef16d782021-12-02T17:47:34ZDistinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis10.1038/s41467-020-16804-62041-1723https://doaj.org/article/798249b34fd54ac1bcfc784baef16d782020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16804-6https://doaj.org/toc/2041-1723Changes in osmotic homeostasis alter metabolites and therefore chemical milieu of the cells. Here, the authors show that altering metabolites in E. coli also change the cellular capacity for buffering mutations that impair protein folding and influences proteostasis irrespective of molecular chaperonesKanika VermaKanika SaxenaRajashekar DonakaAseem ChaphalkarManish Kumar RaiAnurag ShuklaZainab ZaidiRohan DandageDhanasekaran ShanmugamKausik ChakrabortyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kanika Verma Kanika Saxena Rajashekar Donaka Aseem Chaphalkar Manish Kumar Rai Anurag Shukla Zainab Zaidi Rohan Dandage Dhanasekaran Shanmugam Kausik Chakraborty Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
description	Changes in osmotic homeostasis alter metabolites and therefore chemical milieu of the cells. Here, the authors show that altering metabolites in E. coli also change the cellular capacity for buffering mutations that impair protein folding and influences proteostasis irrespective of molecular chaperones
format	article
author	Kanika Verma Kanika Saxena Rajashekar Donaka Aseem Chaphalkar Manish Kumar Rai Anurag Shukla Zainab Zaidi Rohan Dandage Dhanasekaran Shanmugam Kausik Chakraborty
author_facet	Kanika Verma Kanika Saxena Rajashekar Donaka Aseem Chaphalkar Manish Kumar Rai Anurag Shukla Zainab Zaidi Rohan Dandage Dhanasekaran Shanmugam Kausik Chakraborty
author_sort	Kanika Verma
title	Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
title_short	Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
title_full	Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
title_fullStr	Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
title_full_unstemmed	Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
title_sort	distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/798249b34fd54ac1bcfc784baef16d78
work_keys_str_mv	AT kanikaverma distinctmetabolicstatesofacellguidealternatefatesofmutationalbufferingthroughalteredproteostasis AT kanikasaxena distinctmetabolicstatesofacellguidealternatefatesofmutationalbufferingthroughalteredproteostasis AT rajashekardonaka distinctmetabolicstatesofacellguidealternatefatesofmutationalbufferingthroughalteredproteostasis AT aseemchaphalkar distinctmetabolicstatesofacellguidealternatefatesofmutationalbufferingthroughalteredproteostasis AT manishkumarrai distinctmetabolicstatesofacellguidealternatefatesofmutationalbufferingthroughalteredproteostasis AT anuragshukla distinctmetabolicstatesofacellguidealternatefatesofmutationalbufferingthroughalteredproteostasis AT zainabzaidi distinctmetabolicstatesofacellguidealternatefatesofmutationalbufferingthroughalteredproteostasis AT rohandandage distinctmetabolicstatesofacellguidealternatefatesofmutationalbufferingthroughalteredproteostasis AT dhanasekaranshanmugam distinctmetabolicstatesofacellguidealternatefatesofmutationalbufferingthroughalteredproteostasis AT kausikchakraborty distinctmetabolicstatesofacellguidealternatefatesofmutationalbufferingthroughalteredproteostasis
_version_	1718379475708674048

Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis

Ejemplares similares