Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
Changes in osmotic homeostasis alter metabolites and therefore chemical milieu of the cells. Here, the authors show that altering metabolites in E. coli also change the cellular capacity for buffering mutations that impair protein folding and influences proteostasis irrespective of molecular chapero...
Guardado en:
Autores principales: | Kanika Verma, Kanika Saxena, Rajashekar Donaka, Aseem Chaphalkar, Manish Kumar Rai, Anurag Shukla, Zainab Zaidi, Rohan Dandage, Dhanasekaran Shanmugam, Kausik Chakraborty |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/798249b34fd54ac1bcfc784baef16d78 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Cellular proteostasis decline in human senescence
por: Karli Montague-Cardoso
Publicado: (2021) -
Impaired proteostasis contributes to renal tubular dysgenesis.
por: Rita Machado de Oliveira, et al.
Publicado: (2011) -
USP11 controls R-loops by regulating senataxin proteostasis
por: Mateusz Jurga, et al.
Publicado: (2021) -
A biosensor-based framework to measure latent proteostasis capacity
por: Rebecca J. Wood, et al.
Publicado: (2018) -
The Fate of the Scientist, the Fate of Science
por: E. B. Rashkovsky
Publicado: (2012)