Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.
Homozygosity for Slc25a21(tm1a(KOMP)Wtsi) results in mice exhibiting orofacial abnormalities, alterations in carpal and rugae structures, hearing impairment and inflammation in the middle ear. In humans it has been hypothesised that the 2-oxoadipate mitochondrial carrier coded by SLC25A21 may be inv...
Guardado en:
Autores principales: | Simon Maguire, Jeanne Estabel, Neil Ingham, Selina Pearson, Edward Ryder, Damian M Carragher, Nicolas Walker, Sanger MGP Slc25a21 Project Team, James Bussell, Wai-In Chan, Thomas M Keane, David J Adams, Cheryl L Scudamore, Christopher J Lelliott, Ramiro Ramírez-Solis, Natasha A Karp, Karen P Steel, Jacqueline K White, Anna-Karin Gerdin |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
|
Materias: | |
Acceso en línea: | https://doaj.org/article/7985cf02c3584cebbd464cdb2fb6225b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Auditory function in the Tc1 mouse model of down syndrome suggests a limited region of human chromosome 21 involved in otitis media.
por: Stephanie Kuhn, et al.
Publicado: (2012) -
Cytogenetic evaluation of orofacial clefts
por: Anjali Satyen Sabnis, et al.
Publicado: (2021) -
Supplementation with folic acid and orofacial clefts
por: Tovani-Palone,Marcos Roberto, et al.
Publicado: (2017) -
Prevalence of Orofacial Clefts and Associated Factors in Infants
por: S Khosroshahian, et al.
Publicado: (2021) -
Strong grain neighbour effects in polycrystals
por: Hamidreza Abdolvand, et al.
Publicado: (2018)