A Race against Time: Reduced Azithromycin Susceptibility in <italic toggle="yes">Salmonella enterica</italic> Serovar Typhi in Pakistan

ABSTRACT Antimicrobial resistance is an ongoing issue in the treatment of typhoid fever. Resistance to first-line antimicrobials and extensively drug resistant (XDR) Salmonella Typhi isolates in Pakistan have left azithromycin as the only remaining effective oral treatment. Here, we report the emerg...

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Autores principales:	Junaid Iqbal, Irum F. Dehraj, Megan E. Carey, Zoe A. Dyson, Denise Garrett, Jessica C. Seidman, Furqan Kabir, Senjuti Saha, Stephen Baker, Farah N. Qamar
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Salmonella Typhi typhoid fever antimicrobial resistance azithromycin higher MIC Pakistan Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/798601c60b8246afbd2e63cf1e74bacd
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spelling	oai:doaj.org-article:798601c60b8246afbd2e63cf1e74bacd2021-11-15T15:30:51ZA Race against Time: Reduced Azithromycin Susceptibility in <italic toggle="yes">Salmonella enterica</italic> Serovar Typhi in Pakistan10.1128/mSphere.00215-202379-5042https://doaj.org/article/798601c60b8246afbd2e63cf1e74bacd2020-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00215-20https://doaj.org/toc/2379-5042ABSTRACT Antimicrobial resistance is an ongoing issue in the treatment of typhoid fever. Resistance to first-line antimicrobials and extensively drug resistant (XDR) Salmonella Typhi isolates in Pakistan have left azithromycin as the only remaining effective oral treatment. Here, we report the emergence of organisms with a single point mutation in acrB gene, implicated in azithromycin resistance, in a S. Typhi isolate from Pakistan. The isolation of this organism is worrisome and highlights the significance of the introduction of typhoid conjugate vaccine in South Asia. IMPORTANCE The emergence of XDR Salmonella Typhi in Pakistan has left azithromycin as the only viable oral treatment option. Here, we report the detection of an azithromycin resistance-associated mutation in one S. Typhi isolate. This finding is important because any possible spread of azithromycin resistance in S. Typhi isolates would make it nearly impossible to treat in outpatient settings due to the need of injectable antibiotics. Our findings also signify the importance of introduction of typhoid conjugate vaccine in regions of endemicity such as Pakistan.Junaid IqbalIrum F. DehrajMegan E. CareyZoe A. DysonDenise GarrettJessica C. SeidmanFurqan KabirSenjuti SahaStephen BakerFarah N. QamarAmerican Society for MicrobiologyarticleSalmonella Typhityphoid feverantimicrobial resistanceazithromycin higher MICPakistanMicrobiologyQR1-502ENmSphere, Vol 5, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Salmonella Typhi typhoid fever antimicrobial resistance azithromycin higher MIC Pakistan Microbiology QR1-502
spellingShingle	Salmonella Typhi typhoid fever antimicrobial resistance azithromycin higher MIC Pakistan Microbiology QR1-502 Junaid Iqbal Irum F. Dehraj Megan E. Carey Zoe A. Dyson Denise Garrett Jessica C. Seidman Furqan Kabir Senjuti Saha Stephen Baker Farah N. Qamar A Race against Time: Reduced Azithromycin Susceptibility in <italic toggle="yes">Salmonella enterica</italic> Serovar Typhi in Pakistan
description	ABSTRACT Antimicrobial resistance is an ongoing issue in the treatment of typhoid fever. Resistance to first-line antimicrobials and extensively drug resistant (XDR) Salmonella Typhi isolates in Pakistan have left azithromycin as the only remaining effective oral treatment. Here, we report the emergence of organisms with a single point mutation in acrB gene, implicated in azithromycin resistance, in a S. Typhi isolate from Pakistan. The isolation of this organism is worrisome and highlights the significance of the introduction of typhoid conjugate vaccine in South Asia. IMPORTANCE The emergence of XDR Salmonella Typhi in Pakistan has left azithromycin as the only viable oral treatment option. Here, we report the detection of an azithromycin resistance-associated mutation in one S. Typhi isolate. This finding is important because any possible spread of azithromycin resistance in S. Typhi isolates would make it nearly impossible to treat in outpatient settings due to the need of injectable antibiotics. Our findings also signify the importance of introduction of typhoid conjugate vaccine in regions of endemicity such as Pakistan.
format	article
author	Junaid Iqbal Irum F. Dehraj Megan E. Carey Zoe A. Dyson Denise Garrett Jessica C. Seidman Furqan Kabir Senjuti Saha Stephen Baker Farah N. Qamar
author_facet	Junaid Iqbal Irum F. Dehraj Megan E. Carey Zoe A. Dyson Denise Garrett Jessica C. Seidman Furqan Kabir Senjuti Saha Stephen Baker Farah N. Qamar
author_sort	Junaid Iqbal
title	A Race against Time: Reduced Azithromycin Susceptibility in <italic toggle="yes">Salmonella enterica</italic> Serovar Typhi in Pakistan
title_short	A Race against Time: Reduced Azithromycin Susceptibility in <italic toggle="yes">Salmonella enterica</italic> Serovar Typhi in Pakistan
title_full	A Race against Time: Reduced Azithromycin Susceptibility in <italic toggle="yes">Salmonella enterica</italic> Serovar Typhi in Pakistan
title_fullStr	A Race against Time: Reduced Azithromycin Susceptibility in <italic toggle="yes">Salmonella enterica</italic> Serovar Typhi in Pakistan
title_full_unstemmed	A Race against Time: Reduced Azithromycin Susceptibility in <italic toggle="yes">Salmonella enterica</italic> Serovar Typhi in Pakistan
title_sort	race against time: reduced azithromycin susceptibility in <italic toggle="yes">salmonella enterica</italic> serovar typhi in pakistan
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/798601c60b8246afbd2e63cf1e74bacd
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A Race against Time: Reduced Azithromycin Susceptibility in <italic toggle="yes">Salmonella enterica</italic> Serovar Typhi in Pakistan

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