An ECHO of Cartilage: In Silico Prediction of Combinatorial Treatments to Switch Between Transient and Permanent Cartilage Phenotypes With Ex Vivo Validation

An ECHO of Cartilage: In Silico Prediction of Combinatorial Treatments to Switch Between Transient and Permanent Cartilage Phenotypes With Ex Vivo Validation

A fundamental question in cartilage biology is: what determines the switch between permanent cartilage found in the articular joints and transient hypertrophic cartilage that functions as a template for bone? This switch is observed both in a subset of OA patients that develop osteophytes, as well a...

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Bibliographic Details
Main Authors: Sakshi Khurana, Stefano Schivo, Jacqueline R. M. Plass, Nikolas Mersinis, Jetse Scholma, Johan Kerkhofs, Leilei Zhong, Jaco van de Pol, Rom Langerak, Liesbet Geris, Marcel Karperien, Janine N. Post
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
computational model
signal transduction
IGF
BMP7
PTHrP
chondrogenesis
Biotechnology
TP248.13-248.65
Online Access:https://doaj.org/article/7987b8cda5b64370984e24d6236274bd
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https://doaj.org/article/7987b8cda5b64370984e24d6236274bd

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