Cardiac sarcoidosis: from diagnosis to treatment

Sarcoidosis is a systemic granulomatous disease of unknown cause. Its clinical presentations are heterogeneous and virtually any organ system can be affected, most commonly lungs. The manifestations of cardiac sarcoidosis (CS) are heterogenous depending on the extent and location of the disease and...

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Autores principales: Kristyna Kysperska, Petr Kuchynka, Tomas Palecek
Formato: article
Lenguaje:EN
Publicado: Palacký University Olomouc, Faculty of Medicine and Dentistry 2021
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Acceso en línea:https://doaj.org/article/7987ddad89f446a5815c9cedfcade5d3
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spelling oai:doaj.org-article:7987ddad89f446a5815c9cedfcade5d32021-11-29T09:17:21ZCardiac sarcoidosis: from diagnosis to treatment1213-81181804-7521https://doaj.org/article/7987ddad89f446a5815c9cedfcade5d32021-11-01T00:00:00Zhttps://biomed.papers.upol.cz/artkey/bio-202104-0001_cardiac-sarcoidosis-from-diagnosis-to-treatment.phphttps://doaj.org/toc/1213-8118https://doaj.org/toc/1804-7521Sarcoidosis is a systemic granulomatous disease of unknown cause. Its clinical presentations are heterogeneous and virtually any organ system can be affected, most commonly lungs. The manifestations of cardiac sarcoidosis (CS) are heterogenous depending on the extent and location of the disease and range from asymptomatic forms to life-threatening arrhythmias as well as to progressive heart failure. Cardiac involvement is associated with a worse prognosis. The diagnosis of CS is often challenging and requires a multimodality approach based on current international recommendations. Pharmacological treatment of CS is based on administration of anti-inflammatory therapy (mainly corticosteroids), which is often combined with heart failure medication and/or antiarrhythmics. Nonpharmacological therapeutic approaches in CS cover pacemaker or defibrillator implantation, catheter ablations and heart transplantation. This review aims to summarize the current understanding of CS including its epidemiology, etiopathogenesis, clinical presentations, diagnostic approaches, and therapeutic possibilities.Kristyna KysperskaPetr KuchynkaTomas PalecekPalacký University Olomouc, Faculty of Medicine and Dentistryarticlegranulomasfdg-pet/ctconduction disordersventricular arrhythmiasheart failureMedicineRENBiomedical Papers, Vol 165, Iss 4, Pp 347-359 (2021)
institution DOAJ
collection DOAJ
language EN
topic granulomas
fdg-pet/ct
conduction disorders
ventricular arrhythmias
heart failure
Medicine
R
spellingShingle granulomas
fdg-pet/ct
conduction disorders
ventricular arrhythmias
heart failure
Medicine
R
Kristyna Kysperska
Petr Kuchynka
Tomas Palecek
Cardiac sarcoidosis: from diagnosis to treatment
description Sarcoidosis is a systemic granulomatous disease of unknown cause. Its clinical presentations are heterogeneous and virtually any organ system can be affected, most commonly lungs. The manifestations of cardiac sarcoidosis (CS) are heterogenous depending on the extent and location of the disease and range from asymptomatic forms to life-threatening arrhythmias as well as to progressive heart failure. Cardiac involvement is associated with a worse prognosis. The diagnosis of CS is often challenging and requires a multimodality approach based on current international recommendations. Pharmacological treatment of CS is based on administration of anti-inflammatory therapy (mainly corticosteroids), which is often combined with heart failure medication and/or antiarrhythmics. Nonpharmacological therapeutic approaches in CS cover pacemaker or defibrillator implantation, catheter ablations and heart transplantation. This review aims to summarize the current understanding of CS including its epidemiology, etiopathogenesis, clinical presentations, diagnostic approaches, and therapeutic possibilities.
format article
author Kristyna Kysperska
Petr Kuchynka
Tomas Palecek
author_facet Kristyna Kysperska
Petr Kuchynka
Tomas Palecek
author_sort Kristyna Kysperska
title Cardiac sarcoidosis: from diagnosis to treatment
title_short Cardiac sarcoidosis: from diagnosis to treatment
title_full Cardiac sarcoidosis: from diagnosis to treatment
title_fullStr Cardiac sarcoidosis: from diagnosis to treatment
title_full_unstemmed Cardiac sarcoidosis: from diagnosis to treatment
title_sort cardiac sarcoidosis: from diagnosis to treatment
publisher Palacký University Olomouc, Faculty of Medicine and Dentistry
publishDate 2021
url https://doaj.org/article/7987ddad89f446a5815c9cedfcade5d3
work_keys_str_mv AT kristynakysperska cardiacsarcoidosisfromdiagnosistotreatment
AT petrkuchynka cardiacsarcoidosisfromdiagnosistotreatment
AT tomaspalecek cardiacsarcoidosisfromdiagnosistotreatment
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