Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration

Neurons are subjected to strains due to body movements and their locations within organs and tissues. Here the authors show that UNC-70/β-spectrin and TBC-10 dynamically maintain attachment of the axon within the epidermis non-cell-autonomously by stabilizing hemidesmosome attachment, preventing axo...

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Autores principales:	Sean Coakley, Fiona K. Ritchie, Kate M. Galbraith, Massimo A. Hilliard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7988a664ddb54a37b81626780cf423c1
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spelling	oai:doaj.org-article:7988a664ddb54a37b81626780cf423c12021-12-02T14:40:53ZEpidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration10.1038/s41467-019-13795-x2041-1723https://doaj.org/article/7988a664ddb54a37b81626780cf423c12020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13795-xhttps://doaj.org/toc/2041-1723Neurons are subjected to strains due to body movements and their locations within organs and tissues. Here the authors show that UNC-70/β-spectrin and TBC-10 dynamically maintain attachment of the axon within the epidermis non-cell-autonomously by stabilizing hemidesmosome attachment, preventing axon degeneration.Sean CoakleyFiona K. RitchieKate M. GalbraithMassimo A. HilliardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sean Coakley Fiona K. Ritchie Kate M. Galbraith Massimo A. Hilliard Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration
description	Neurons are subjected to strains due to body movements and their locations within organs and tissues. Here the authors show that UNC-70/β-spectrin and TBC-10 dynamically maintain attachment of the axon within the epidermis non-cell-autonomously by stabilizing hemidesmosome attachment, preventing axon degeneration.
format	article
author	Sean Coakley Fiona K. Ritchie Kate M. Galbraith Massimo A. Hilliard
author_facet	Sean Coakley Fiona K. Ritchie Kate M. Galbraith Massimo A. Hilliard
author_sort	Sean Coakley
title	Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration
title_short	Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration
title_full	Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration
title_fullStr	Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration
title_full_unstemmed	Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration
title_sort	epidermal control of axonal attachment via β-spectrin and the gtpase-activating protein tbc-10 prevents axonal degeneration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7988a664ddb54a37b81626780cf423c1
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Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration

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