Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

Cell surface proteins contribute to neuronal development and activity-dependent synaptic plasticity. Here, the authors perform a time-resolved surfaceome analysis of developing primary neurons and in response to homeostatic synaptic scaling and chemical long-term potentiation (cLTP), revealing surfa...

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Autores principales:	Marc van Oostrum, Benjamin Campbell, Charlotte Seng, Maik Müller, Susanne tom Dieck, Jacqueline Hammer, Patrick G. A. Pedrioli, Csaba Földy, Shiva K. Tyagarajan, Bernd Wollscheid
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/798a0222f1cc45678a4c20efbeb73d27
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spelling	oai:doaj.org-article:798a0222f1cc45678a4c20efbeb73d272021-12-02T18:37:17ZSurfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity10.1038/s41467-020-18494-62041-1723https://doaj.org/article/798a0222f1cc45678a4c20efbeb73d272020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18494-6https://doaj.org/toc/2041-1723Cell surface proteins contribute to neuronal development and activity-dependent synaptic plasticity. Here, the authors perform a time-resolved surfaceome analysis of developing primary neurons and in response to homeostatic synaptic scaling and chemical long-term potentiation (cLTP), revealing surface proteome remodeling largely independent of global proteostasis.Marc van OostrumBenjamin CampbellCharlotte SengMaik MüllerSusanne tom DieckJacqueline HammerPatrick G. A. PedrioliCsaba FöldyShiva K. TyagarajanBernd WollscheidNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marc van Oostrum Benjamin Campbell Charlotte Seng Maik Müller Susanne tom Dieck Jacqueline Hammer Patrick G. A. Pedrioli Csaba Földy Shiva K. Tyagarajan Bernd Wollscheid Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
description	Cell surface proteins contribute to neuronal development and activity-dependent synaptic plasticity. Here, the authors perform a time-resolved surfaceome analysis of developing primary neurons and in response to homeostatic synaptic scaling and chemical long-term potentiation (cLTP), revealing surface proteome remodeling largely independent of global proteostasis.
format	article
author	Marc van Oostrum Benjamin Campbell Charlotte Seng Maik Müller Susanne tom Dieck Jacqueline Hammer Patrick G. A. Pedrioli Csaba Földy Shiva K. Tyagarajan Bernd Wollscheid
author_facet	Marc van Oostrum Benjamin Campbell Charlotte Seng Maik Müller Susanne tom Dieck Jacqueline Hammer Patrick G. A. Pedrioli Csaba Földy Shiva K. Tyagarajan Bernd Wollscheid
author_sort	Marc van Oostrum
title	Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
title_short	Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
title_full	Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
title_fullStr	Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
title_full_unstemmed	Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
title_sort	surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/798a0222f1cc45678a4c20efbeb73d27
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_version_	1718377805922697216

Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

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