Tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth

Abstract Ancient dental pulps are highly precious samples because they conserve DNA from humans and blood-borne pathogens for ages. However, little is known about the microbial communities present in dental pulps. Here, we analyzed ancient and modern dental pulp samples from different time periods a...

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Autores principales:	Nicolás Rascovan, Hong Huynh, Gérard Chouin, Kolawole Adekola, Patrice Georges-Zimmermann, Michel Signoli, Yves Desfosses, Gérard Aboudharam, Michel Drancourt, Christelle Desnues
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/798a20ff9466482fb677cab8c80c9aa8
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spelling	oai:doaj.org-article:798a20ff9466482fb677cab8c80c9aa82021-12-02T11:42:16ZTracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth10.1038/s41522-016-0008-82055-5008https://doaj.org/article/798a20ff9466482fb677cab8c80c9aa82016-12-01T00:00:00Zhttps://doi.org/10.1038/s41522-016-0008-8https://doaj.org/toc/2055-5008Abstract Ancient dental pulps are highly precious samples because they conserve DNA from humans and blood-borne pathogens for ages. However, little is known about the microbial communities present in dental pulps. Here, we analyzed ancient and modern dental pulp samples from different time periods and geographic regions and found that they are colonized by distinct microbial communities, which can be differentiated from other oral cavity samples. We found that despite the presence of environmental bacteria, ancient dental pulps conserve a clear and well-conserved record of oral microbes. We were able to detect several different oral pathogens in ancient and modern dental pulps, which are commonly associated with periodontal diseases. We thus showed that ancient dental pulps are not only valuable sources of DNA from humans and systemic infections, but also an open window for the study of ancient oral microbiomes.Nicolás RascovanHong HuynhGérard ChouinKolawole AdekolaPatrice Georges-ZimmermannMichel SignoliYves DesfossesGérard AboudharamMichel DrancourtChristelle DesnuesNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 2, Iss 1, Pp 1-4 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Nicolás Rascovan Hong Huynh Gérard Chouin Kolawole Adekola Patrice Georges-Zimmermann Michel Signoli Yves Desfosses Gérard Aboudharam Michel Drancourt Christelle Desnues Tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth
description	Abstract Ancient dental pulps are highly precious samples because they conserve DNA from humans and blood-borne pathogens for ages. However, little is known about the microbial communities present in dental pulps. Here, we analyzed ancient and modern dental pulp samples from different time periods and geographic regions and found that they are colonized by distinct microbial communities, which can be differentiated from other oral cavity samples. We found that despite the presence of environmental bacteria, ancient dental pulps conserve a clear and well-conserved record of oral microbes. We were able to detect several different oral pathogens in ancient and modern dental pulps, which are commonly associated with periodontal diseases. We thus showed that ancient dental pulps are not only valuable sources of DNA from humans and systemic infections, but also an open window for the study of ancient oral microbiomes.
format	article
author	Nicolás Rascovan Hong Huynh Gérard Chouin Kolawole Adekola Patrice Georges-Zimmermann Michel Signoli Yves Desfosses Gérard Aboudharam Michel Drancourt Christelle Desnues
author_facet	Nicolás Rascovan Hong Huynh Gérard Chouin Kolawole Adekola Patrice Georges-Zimmermann Michel Signoli Yves Desfosses Gérard Aboudharam Michel Drancourt Christelle Desnues
author_sort	Nicolás Rascovan
title	Tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth
title_short	Tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth
title_full	Tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth
title_fullStr	Tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth
title_full_unstemmed	Tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth
title_sort	tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/798a20ff9466482fb677cab8c80c9aa8
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Tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth

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