Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

Astrocytes have functions crucial for brain homeostasis, which are disrupted in many neurological disorders, but how these functions are established during astrocyte maturation is largely unknown. Here the authors show transcriptional and chromatin changes underlying astrocyte maturation in mice and...

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Autores principales:	Michael Lattke, Robert Goldstone, James K. Ellis, Stefan Boeing, Jerónimo Jurado-Arjona, Nicolás Marichal, James I. MacRae, Benedikt Berninger, Francois Guillemot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/798f138617cc451ba7602ca0f438bd2d
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spelling	oai:doaj.org-article:798f138617cc451ba7602ca0f438bd2d2021-12-02T15:33:16ZExtensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture10.1038/s41467-021-24624-52041-1723https://doaj.org/article/798f138617cc451ba7602ca0f438bd2d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24624-5https://doaj.org/toc/2041-1723Astrocytes have functions crucial for brain homeostasis, which are disrupted in many neurological disorders, but how these functions are established during astrocyte maturation is largely unknown. Here the authors show transcriptional and chromatin changes underlying astrocyte maturation in mice and identify transcription factors regulating maturation of cultured astrocytes.Michael LattkeRobert GoldstoneJames K. EllisStefan BoeingJerónimo Jurado-ArjonaNicolás MarichalJames I. MacRaeBenedikt BerningerFrancois GuillemotNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Lattke Robert Goldstone James K. Ellis Stefan Boeing Jerónimo Jurado-Arjona Nicolás Marichal James I. MacRae Benedikt Berninger Francois Guillemot Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture
description	Astrocytes have functions crucial for brain homeostasis, which are disrupted in many neurological disorders, but how these functions are established during astrocyte maturation is largely unknown. Here the authors show transcriptional and chromatin changes underlying astrocyte maturation in mice and identify transcription factors regulating maturation of cultured astrocytes.
format	article
author	Michael Lattke Robert Goldstone James K. Ellis Stefan Boeing Jerónimo Jurado-Arjona Nicolás Marichal James I. MacRae Benedikt Berninger Francois Guillemot
author_facet	Michael Lattke Robert Goldstone James K. Ellis Stefan Boeing Jerónimo Jurado-Arjona Nicolás Marichal James I. MacRae Benedikt Berninger Francois Guillemot
author_sort	Michael Lattke
title	Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture
title_short	Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture
title_full	Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture
title_fullStr	Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture
title_full_unstemmed	Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture
title_sort	extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/798f138617cc451ba7602ca0f438bd2d
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Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

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