The epidemiology of premature aging and associated comorbidities

Fabio Coppedè Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy Abstract: Hutchinson–Gilford Progeria Syndrome and Werner syndrome, also known as childhood- and adulthood-progeria, respectively, represent two of t...

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Autor principal:	Coppedè F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Hutchinson–Gilford Progeria Syndrome Werner syndrome premature aging disorders epidemiology cardiovascular diseases cancer atherosclerosis genetics sign and symptoms Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7991b857163044eeadb177ba0e3bd180
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spelling	oai:doaj.org-article:7991b857163044eeadb177ba0e3bd1802021-12-02T03:43:09ZThe epidemiology of premature aging and associated comorbidities1178-1998https://doaj.org/article/7991b857163044eeadb177ba0e3bd1802013-08-01T00:00:00Zhttps://www.dovepress.com/the-epidemiology-of-premature-aging-and-associated-comorbidities-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Fabio Coppedè Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy Abstract: Hutchinson–Gilford Progeria Syndrome and Werner syndrome, also known as childhood- and adulthood-progeria, respectively, represent two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. The discovery of their genetic basis has led to the identification of several gene mutations leading to a spectrum of progeroid phenotypes ranging from moderate and mild–severe to very aggressive forms. In parallel, the creation of disease registers and databases provided available data for the design of relatively large-scale epidemiological studies, thereby allowing a better understanding of the nature and frequency of the premature aging-associated signs and symptoms. The aim of this article is to review the most recent findings concerning the epidemiology of premature aging disorders, their genetic basis, and the most recent reports on the frequency of associated diseases. Keywords: Hutchinson–Gilford Progeria Syndrome, Werner syndrome, premature aging disorders, epidemiology, cardiovascular diseases, cancer, atherosclerosis, genetics, sign and symptomsCoppedè FDove Medical PressarticleHutchinson–Gilford Progeria SyndromeWerner syndromepremature aging disordersepidemiologycardiovascular diseasescanceratherosclerosisgeneticssign and symptomsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 1023-1032 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hutchinson–Gilford Progeria Syndrome Werner syndrome premature aging disorders epidemiology cardiovascular diseases cancer atherosclerosis genetics sign and symptoms Geriatrics RC952-954.6
spellingShingle	Hutchinson–Gilford Progeria Syndrome Werner syndrome premature aging disorders epidemiology cardiovascular diseases cancer atherosclerosis genetics sign and symptoms Geriatrics RC952-954.6 Coppedè F The epidemiology of premature aging and associated comorbidities
description	Fabio Coppedè Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy Abstract: Hutchinson–Gilford Progeria Syndrome and Werner syndrome, also known as childhood- and adulthood-progeria, respectively, represent two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. The discovery of their genetic basis has led to the identification of several gene mutations leading to a spectrum of progeroid phenotypes ranging from moderate and mild–severe to very aggressive forms. In parallel, the creation of disease registers and databases provided available data for the design of relatively large-scale epidemiological studies, thereby allowing a better understanding of the nature and frequency of the premature aging-associated signs and symptoms. The aim of this article is to review the most recent findings concerning the epidemiology of premature aging disorders, their genetic basis, and the most recent reports on the frequency of associated diseases. Keywords: Hutchinson–Gilford Progeria Syndrome, Werner syndrome, premature aging disorders, epidemiology, cardiovascular diseases, cancer, atherosclerosis, genetics, sign and symptoms
format	article
author	Coppedè F
author_facet	Coppedè F
author_sort	Coppedè F
title	The epidemiology of premature aging and associated comorbidities
title_short	The epidemiology of premature aging and associated comorbidities
title_full	The epidemiology of premature aging and associated comorbidities
title_fullStr	The epidemiology of premature aging and associated comorbidities
title_full_unstemmed	The epidemiology of premature aging and associated comorbidities
title_sort	epidemiology of premature aging and associated comorbidities
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/7991b857163044eeadb177ba0e3bd180
work_keys_str_mv	AT coppedegravef theepidemiologyofprematureagingandassociatedcomorbidities AT coppedegravef epidemiologyofprematureagingandassociatedcomorbidities
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The epidemiology of premature aging and associated comorbidities

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