Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at age 10: findings from the Avon Longitudinal Study of Parents and Children.

<h4>Background</h4>Iron deficiency is common during pregnancy. Experimental animal studies suggest that it increases cardiovascular risk in the offspring.<h4>Objective</h4>To examine the relationship between maternal pregnancy dietary and supplement iron intake and hemoglobin...

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Autores principales:	Nisreen A Alwan, Janet E Cade, Darren C Greenwood, John Deanfield, Debbie A Lawlor
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7991fd644b104a0babda1ff7e5f64040
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spelling	oai:doaj.org-article:7991fd644b104a0babda1ff7e5f640402021-11-18T08:38:50ZAssociations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at age 10: findings from the Avon Longitudinal Study of Parents and Children.1932-620310.1371/journal.pone.0084684https://doaj.org/article/7991fd644b104a0babda1ff7e5f640402014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24400110/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Iron deficiency is common during pregnancy. Experimental animal studies suggest that it increases cardiovascular risk in the offspring.<h4>Objective</h4>To examine the relationship between maternal pregnancy dietary and supplement iron intake and hemoglobin, with offspring's arterial stiffness (measured by carotid-radial pulse wave velocity), endothelial function (measured by brachial artery flow mediated dilatation), blood pressure, and adiposity (measured by body mass index), test for mediation by cord ferritin, birth weight, gestational age, and child dietary iron intake, and for effect modification by maternal vitamin C intake and offspring sex.<h4>Design</h4>Prospective data from 2958 mothers and children pairs at 10 years of age enrolled in an English birth cohort, the Avon Longitudinal Study for Parents and Children (ALSPAC), was analysed.<h4>Results</h4>2639 (89.2%) mothers reported dietary iron intake in pregnancy below the UK reference nutrient intake of 14.8 mg/day. 1328 (44.9%) reported taking iron supplements, and 129 (4.4%) were anemic by 18 weeks gestation. No associations were observed apart from maternal iron intake from supplements with offspring systolic blood pressure (-0.8 mmHg, 99% CI -1.7 to 0, P = 0.01 in the sample with all relevant data observed, and -0.7 mmHg, 99% CI -1.3 to 0, P = 0.008 in the sample with missing data imputed).<h4>Conclusion</h4>There was no evidence of association between maternal pregnancy dietary iron intake, or maternal hemoglobin concentration (which is less likely to be biased by subjective reporting) with offspring outcomes. There was a modest inverse association between maternal iron supplement intake during pregnancy with offspring systolic blood pressure at 10 years.Nisreen A AlwanJanet E CadeDarren C GreenwoodJohn DeanfieldDebbie A LawlorPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e84684 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nisreen A Alwan Janet E Cade Darren C Greenwood John Deanfield Debbie A Lawlor Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at age 10: findings from the Avon Longitudinal Study of Parents and Children.
description	<h4>Background</h4>Iron deficiency is common during pregnancy. Experimental animal studies suggest that it increases cardiovascular risk in the offspring.<h4>Objective</h4>To examine the relationship between maternal pregnancy dietary and supplement iron intake and hemoglobin, with offspring's arterial stiffness (measured by carotid-radial pulse wave velocity), endothelial function (measured by brachial artery flow mediated dilatation), blood pressure, and adiposity (measured by body mass index), test for mediation by cord ferritin, birth weight, gestational age, and child dietary iron intake, and for effect modification by maternal vitamin C intake and offspring sex.<h4>Design</h4>Prospective data from 2958 mothers and children pairs at 10 years of age enrolled in an English birth cohort, the Avon Longitudinal Study for Parents and Children (ALSPAC), was analysed.<h4>Results</h4>2639 (89.2%) mothers reported dietary iron intake in pregnancy below the UK reference nutrient intake of 14.8 mg/day. 1328 (44.9%) reported taking iron supplements, and 129 (4.4%) were anemic by 18 weeks gestation. No associations were observed apart from maternal iron intake from supplements with offspring systolic blood pressure (-0.8 mmHg, 99% CI -1.7 to 0, P = 0.01 in the sample with all relevant data observed, and -0.7 mmHg, 99% CI -1.3 to 0, P = 0.008 in the sample with missing data imputed).<h4>Conclusion</h4>There was no evidence of association between maternal pregnancy dietary iron intake, or maternal hemoglobin concentration (which is less likely to be biased by subjective reporting) with offspring outcomes. There was a modest inverse association between maternal iron supplement intake during pregnancy with offspring systolic blood pressure at 10 years.
format	article
author	Nisreen A Alwan Janet E Cade Darren C Greenwood John Deanfield Debbie A Lawlor
author_facet	Nisreen A Alwan Janet E Cade Darren C Greenwood John Deanfield Debbie A Lawlor
author_sort	Nisreen A Alwan
title	Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at age 10: findings from the Avon Longitudinal Study of Parents and Children.
title_short	Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at age 10: findings from the Avon Longitudinal Study of Parents and Children.
title_full	Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at age 10: findings from the Avon Longitudinal Study of Parents and Children.
title_fullStr	Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at age 10: findings from the Avon Longitudinal Study of Parents and Children.
title_full_unstemmed	Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at age 10: findings from the Avon Longitudinal Study of Parents and Children.
title_sort	associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at age 10: findings from the avon longitudinal study of parents and children.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7991fd644b104a0babda1ff7e5f64040
work_keys_str_mv	AT nisreenaalwan associationsofmaternalironintakeandhemoglobininpregnancywithoffspringvascularphenotypesandadiposityatage10findingsfromtheavonlongitudinalstudyofparentsandchildren AT janetecade associationsofmaternalironintakeandhemoglobininpregnancywithoffspringvascularphenotypesandadiposityatage10findingsfromtheavonlongitudinalstudyofparentsandchildren AT darrencgreenwood associationsofmaternalironintakeandhemoglobininpregnancywithoffspringvascularphenotypesandadiposityatage10findingsfromtheavonlongitudinalstudyofparentsandchildren AT johndeanfield associationsofmaternalironintakeandhemoglobininpregnancywithoffspringvascularphenotypesandadiposityatage10findingsfromtheavonlongitudinalstudyofparentsandchildren AT debbiealawlor associationsofmaternalironintakeandhemoglobininpregnancywithoffspringvascularphenotypesandadiposityatage10findingsfromtheavonlongitudinalstudyofparentsandchildren
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Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at age 10: findings from the Avon Longitudinal Study of Parents and Children.

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