Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia
Objectives:. About 5% of patients with coronavirus disease-2019 are admitted to the ICU for acute hypoxemic respiratory failure. Opinions differ on whether invasive mechanical ventilation should be used as first-line therapy over noninvasive oxygen support. The aim of the study was to assess the eff...
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Wolters Kluwer
2021
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Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 |
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Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Claire Dupuis, MD, PhD Lila Bouadma, MD, PhD Etienne de Montmollin, MD, PhD Dany Goldgran-Toledano, MD Carole Schwebel, MD, PhD Jean Reignier, MD, PhD Mathilde Neuville, MD Moreno Ursino, PhD Shidasp Siami, MD Stéphane Ruckly, MSc Corinne Alberti, MD, PhD Bruno Mourvillier, MD, PhD Sébastien Bailly, PharmD, PhD Kévin Grapin, MD Virginie Laurent, MD Niccolo Buetti, MD, PhD Marc Gainnier, MD Bertrand Souweine, MD, PhD Jean-François Timsit, MD, PhD for the OUTCOMEREA Study Group Jean-François Timsit Elie Azoulay Maïté Garrouste-Orgeas Jean-Ralph Zahar Bruno Mourvillier Christophe Clec’h Corinne Alberti Stephane Ruckly Sébastien Bailly Aurélien Vannieuwenhuyze Christophe Adrie Carole Agasse Bernard Allaouchiche Olivier Andremont Pascal Andreu Laurent Argaud Claire Ara-Somohano Elie Azoulay Francois Barbier Déborah Boyer Jean-Pierre Bedos Thomas Baudry Jérome Bedel Julien Bohé Lila Bouadma Jeremy Bourenne Noel Brule Cédric Brétonnière Frank Chemouni Christine Cheval Julien Carvelli Elisabeth Coupez Martin Cour Claire Dupuis Etienne de Montmollin Loa Dopeux Anne-Sylvie Dumenil Jean-Marc Forel Marc Gainnier Charlotte Garret Dany Goldgran-Tonedano Steven Grangé Antoine Gros Hédia Hammed Akim Haouache Romain Hernu Tarik Hissem Vivien Hong Tuan Ha Sébastien Jochmans Jean-Baptiste Joffredo Hatem Kallel Guillaume Lacave Virgine Laurent Alexandre Lautrette Clément Le bihan Eric Magalhaes Virgine Lemiale Guillaume Marcotte Jordane Lebut Maxime Lugosi Sibylle Merceron Benoît Misset Mathild Neuville Laurent Nicolet Johanna Oziel Laurent Papazian Juliette Patrier Benjamin Planquette Aguila Radjou Marie Simon Romain Sonneville Jean Reignier Bertrand Souweine Carole Schwebel Shidasp Siami Romain Sonneville Nicolas Terzi Gilles Troché Marie Thuong Guillaume Thierry Marion Venot Sondes Yaacoubi Olivier Zambon Julien Fournier Stéphanie Bagur Mireille Adda Vanessa Vindrieux Sylvie de la Salle Pauline Enguerrand Vincent Gobert Stéphane Guessens Helene Merle Nadira Kaddour Boris Berthe Samir Bekkhouche Kaouttar Mellouk Mélaine Lebrazic Carole Ouisse Diane Maugars Christelle Aparicio Igor Theodose Manal Nouacer Veronique Deiler Fariza Lamara Myriam Moussa Atika Mouaci Nassima Viguier Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia |
description |
Objectives:. About 5% of patients with coronavirus disease-2019 are admitted to the ICU for acute hypoxemic respiratory failure. Opinions differ on whether invasive mechanical ventilation should be used as first-line therapy over noninvasive oxygen support. The aim of the study was to assess the effect of early invasive mechanical ventilation in coronavirus disease-2019 with acute hypoxemic respiratory failure on day-60 mortality.
Design:. Multicenter prospective French observational study.
Setting:. Eleven ICUs of the French OutcomeRea network.
Patients:. Coronavirus disease-2019 patients with acute hypoxemic respiratory failure (Pao2/Fio2 ≤ 300 mm Hg), without shock or neurologic failure on ICU admission, and not referred from another ICU or intermediate care unit were included.
Intervention:. We compared day-60 mortality in patients who were on invasive mechanical ventilation within the first 2 calendar days of the ICU stay (early invasive mechanical ventilation group) and those who were not (nonearly invasive mechanical ventilation group). We used a Cox proportional-hazard model weighted by inverse probability of early invasive mechanical ventilation to determine the risk of death at day 60.
Measurement and Main Results:. The 245 patients included had a median (interquartile range) age of 61 years (52–69 yr), a Simplified Acute Physiology Score II score of 34 mm Hg (26–44 mm Hg), and a Pao2/Fio2 of 121 mm Hg (90–174 mm Hg). The rates of ICU-acquired pneumonia, bacteremia, and the ICU length of stay were significantly higher in the early (n = 117 [48%]) than in the nonearly invasive mechanical ventilation group (n = 128 [52%]), p < 0.01. Day-60 mortality was 42.7% and 21.9% in the early and nonearly invasive mechanical ventilation groups, respectively. The weighted model showed that early invasive mechanical ventilation increased the risk for day-60 mortality (weighted hazard ratio =1.74; 95% CI, 1.07–2.83, p=0.03).
Conclusions:. In ICU patients admitted with coronavirus disease-2019-induced acute hypoxemic respiratory failure, early invasive mechanical ventilation was associated with an increased risk of day-60 mortality. This result needs to be confirmed. |
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Claire Dupuis, MD, PhD Lila Bouadma, MD, PhD Etienne de Montmollin, MD, PhD Dany Goldgran-Toledano, MD Carole Schwebel, MD, PhD Jean Reignier, MD, PhD Mathilde Neuville, MD Moreno Ursino, PhD Shidasp Siami, MD Stéphane Ruckly, MSc Corinne Alberti, MD, PhD Bruno Mourvillier, MD, PhD Sébastien Bailly, PharmD, PhD Kévin Grapin, MD Virginie Laurent, MD Niccolo Buetti, MD, PhD Marc Gainnier, MD Bertrand Souweine, MD, PhD Jean-François Timsit, MD, PhD for the OUTCOMEREA Study Group Jean-François Timsit Elie Azoulay Maïté Garrouste-Orgeas Jean-Ralph Zahar Bruno Mourvillier Christophe Clec’h Corinne Alberti Stephane Ruckly Sébastien Bailly Aurélien Vannieuwenhuyze Christophe Adrie Carole Agasse Bernard Allaouchiche Olivier Andremont Pascal Andreu Laurent Argaud Claire Ara-Somohano Elie Azoulay Francois Barbier Déborah Boyer Jean-Pierre Bedos Thomas Baudry Jérome Bedel Julien Bohé Lila Bouadma Jeremy Bourenne Noel Brule Cédric Brétonnière Frank Chemouni Christine Cheval Julien Carvelli Elisabeth Coupez Martin Cour Claire Dupuis Etienne de Montmollin Loa Dopeux Anne-Sylvie Dumenil Jean-Marc Forel Marc Gainnier Charlotte Garret Dany Goldgran-Tonedano Steven Grangé Antoine Gros Hédia Hammed Akim Haouache Romain Hernu Tarik Hissem Vivien Hong Tuan Ha Sébastien Jochmans Jean-Baptiste Joffredo Hatem Kallel Guillaume Lacave Virgine Laurent Alexandre Lautrette Clément Le bihan Eric Magalhaes Virgine Lemiale Guillaume Marcotte Jordane Lebut Maxime Lugosi Sibylle Merceron Benoît Misset Mathild Neuville Laurent Nicolet Johanna Oziel Laurent Papazian Juliette Patrier Benjamin Planquette Aguila Radjou Marie Simon Romain Sonneville Jean Reignier Bertrand Souweine Carole Schwebel Shidasp Siami Romain Sonneville Nicolas Terzi Gilles Troché Marie Thuong Guillaume Thierry Marion Venot Sondes Yaacoubi Olivier Zambon Julien Fournier Stéphanie Bagur Mireille Adda Vanessa Vindrieux Sylvie de la Salle Pauline Enguerrand Vincent Gobert Stéphane Guessens Helene Merle Nadira Kaddour Boris Berthe Samir Bekkhouche Kaouttar Mellouk Mélaine Lebrazic Carole Ouisse Diane Maugars Christelle Aparicio Igor Theodose Manal Nouacer Veronique Deiler Fariza Lamara Myriam Moussa Atika Mouaci Nassima Viguier |
author_facet |
Claire Dupuis, MD, PhD Lila Bouadma, MD, PhD Etienne de Montmollin, MD, PhD Dany Goldgran-Toledano, MD Carole Schwebel, MD, PhD Jean Reignier, MD, PhD Mathilde Neuville, MD Moreno Ursino, PhD Shidasp Siami, MD Stéphane Ruckly, MSc Corinne Alberti, MD, PhD Bruno Mourvillier, MD, PhD Sébastien Bailly, PharmD, PhD Kévin Grapin, MD Virginie Laurent, MD Niccolo Buetti, MD, PhD Marc Gainnier, MD Bertrand Souweine, MD, PhD Jean-François Timsit, MD, PhD for the OUTCOMEREA Study Group Jean-François Timsit Elie Azoulay Maïté Garrouste-Orgeas Jean-Ralph Zahar Bruno Mourvillier Christophe Clec’h Corinne Alberti Stephane Ruckly Sébastien Bailly Aurélien Vannieuwenhuyze Christophe Adrie Carole Agasse Bernard Allaouchiche Olivier Andremont Pascal Andreu Laurent Argaud Claire Ara-Somohano Elie Azoulay Francois Barbier Déborah Boyer Jean-Pierre Bedos Thomas Baudry Jérome Bedel Julien Bohé Lila Bouadma Jeremy Bourenne Noel Brule Cédric Brétonnière Frank Chemouni Christine Cheval Julien Carvelli Elisabeth Coupez Martin Cour Claire Dupuis Etienne de Montmollin Loa Dopeux Anne-Sylvie Dumenil Jean-Marc Forel Marc Gainnier Charlotte Garret Dany Goldgran-Tonedano Steven Grangé Antoine Gros Hédia Hammed Akim Haouache Romain Hernu Tarik Hissem Vivien Hong Tuan Ha Sébastien Jochmans Jean-Baptiste Joffredo Hatem Kallel Guillaume Lacave Virgine Laurent Alexandre Lautrette Clément Le bihan Eric Magalhaes Virgine Lemiale Guillaume Marcotte Jordane Lebut Maxime Lugosi Sibylle Merceron Benoît Misset Mathild Neuville Laurent Nicolet Johanna Oziel Laurent Papazian Juliette Patrier Benjamin Planquette Aguila Radjou Marie Simon Romain Sonneville Jean Reignier Bertrand Souweine Carole Schwebel Shidasp Siami Romain Sonneville Nicolas Terzi Gilles Troché Marie Thuong Guillaume Thierry Marion Venot Sondes Yaacoubi Olivier Zambon Julien Fournier Stéphanie Bagur Mireille Adda Vanessa Vindrieux Sylvie de la Salle Pauline Enguerrand Vincent Gobert Stéphane Guessens Helene Merle Nadira Kaddour Boris Berthe Samir Bekkhouche Kaouttar Mellouk Mélaine Lebrazic Carole Ouisse Diane Maugars Christelle Aparicio Igor Theodose Manal Nouacer Veronique Deiler Fariza Lamara Myriam Moussa Atika Mouaci Nassima Viguier |
author_sort |
Claire Dupuis, MD, PhD |
title |
Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia |
title_short |
Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia |
title_full |
Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia |
title_fullStr |
Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia |
title_full_unstemmed |
Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia |
title_sort |
association between early invasive mechanical ventilation and day-60 mortality in acute hypoxemic respiratory failure related to coronavirus disease-2019 pneumonia |
publisher |
Wolters Kluwer |
publishDate |
2021 |
url |
https://doaj.org/article/7992e6fc16bf4265b38c940cc4a5e043 |
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oai:doaj.org-article:7992e6fc16bf4265b38c940cc4a5e0432021-11-25T07:53:30ZAssociation Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia2639-802810.1097/CCE.0000000000000329https://doaj.org/article/7992e6fc16bf4265b38c940cc4a5e0432021-01-01T00:00:00Zhttp://journals.lww.com/10.1097/CCE.0000000000000329https://doaj.org/toc/2639-8028Objectives:. About 5% of patients with coronavirus disease-2019 are admitted to the ICU for acute hypoxemic respiratory failure. Opinions differ on whether invasive mechanical ventilation should be used as first-line therapy over noninvasive oxygen support. The aim of the study was to assess the effect of early invasive mechanical ventilation in coronavirus disease-2019 with acute hypoxemic respiratory failure on day-60 mortality. Design:. Multicenter prospective French observational study. Setting:. Eleven ICUs of the French OutcomeRea network. Patients:. Coronavirus disease-2019 patients with acute hypoxemic respiratory failure (Pao2/Fio2 ≤ 300 mm Hg), without shock or neurologic failure on ICU admission, and not referred from another ICU or intermediate care unit were included. Intervention:. We compared day-60 mortality in patients who were on invasive mechanical ventilation within the first 2 calendar days of the ICU stay (early invasive mechanical ventilation group) and those who were not (nonearly invasive mechanical ventilation group). We used a Cox proportional-hazard model weighted by inverse probability of early invasive mechanical ventilation to determine the risk of death at day 60. Measurement and Main Results:. The 245 patients included had a median (interquartile range) age of 61 years (52–69 yr), a Simplified Acute Physiology Score II score of 34 mm Hg (26–44 mm Hg), and a Pao2/Fio2 of 121 mm Hg (90–174 mm Hg). The rates of ICU-acquired pneumonia, bacteremia, and the ICU length of stay were significantly higher in the early (n = 117 [48%]) than in the nonearly invasive mechanical ventilation group (n = 128 [52%]), p < 0.01. Day-60 mortality was 42.7% and 21.9% in the early and nonearly invasive mechanical ventilation groups, respectively. The weighted model showed that early invasive mechanical ventilation increased the risk for day-60 mortality (weighted hazard ratio =1.74; 95% CI, 1.07–2.83, p=0.03). Conclusions:. In ICU patients admitted with coronavirus disease-2019-induced acute hypoxemic respiratory failure, early invasive mechanical ventilation was associated with an increased risk of day-60 mortality. This result needs to be confirmed.Claire Dupuis, MD, PhDLila Bouadma, MD, PhDEtienne de Montmollin, MD, PhDDany Goldgran-Toledano, MDCarole Schwebel, MD, PhDJean Reignier, MD, PhDMathilde Neuville, MDMoreno Ursino, PhDShidasp Siami, MDStéphane Ruckly, MScCorinne Alberti, MD, PhDBruno Mourvillier, MD, PhDSébastien Bailly, PharmD, PhDKévin Grapin, MDVirginie Laurent, MDNiccolo Buetti, MD, PhDMarc Gainnier, MDBertrand Souweine, MD, PhDJean-François Timsit, MD, PhDfor the OUTCOMEREA Study GroupJean-François TimsitElie AzoulayMaïté Garrouste-OrgeasJean-Ralph ZaharBruno MourvillierChristophe Clec’hCorinne AlbertiStephane RucklySébastien BaillyAurélien VannieuwenhuyzeChristophe AdrieCarole AgasseBernard AllaouchicheOlivier AndremontPascal AndreuLaurent ArgaudClaire Ara-SomohanoElie AzoulayFrancois BarbierDéborah BoyerJean-Pierre BedosThomas BaudryJérome BedelJulien BohéLila BouadmaJeremy BourenneNoel BruleCédric BrétonnièreFrank ChemouniChristine ChevalJulien CarvelliElisabeth CoupezMartin CourClaire DupuisEtienne de MontmollinLoa DopeuxAnne-Sylvie DumenilJean-Marc ForelMarc GainnierCharlotte GarretDany Goldgran-TonedanoSteven GrangéAntoine GrosHédia HammedAkim HaouacheRomain HernuTarik HissemVivien Hong Tuan HaSébastien JochmansJean-Baptiste JoffredoHatem KallelGuillaume LacaveVirgine LaurentAlexandre LautretteClément Le bihanEric MagalhaesVirgine LemialeGuillaume MarcotteJordane LebutMaxime LugosiSibylle MerceronBenoît MissetMathild NeuvilleLaurent NicoletJohanna OzielLaurent PapazianJuliette PatrierBenjamin PlanquetteAguila RadjouMarie SimonRomain SonnevilleJean ReignierBertrand SouweineCarole SchwebelShidasp SiamiRomain SonnevilleNicolas TerziGilles TrochéMarie ThuongGuillaume ThierryMarion VenotSondes YaacoubiOlivier ZambonJulien FournierStéphanie BagurMireille AddaVanessa VindrieuxSylvie de la SallePauline EnguerrandVincent GobertStéphane GuessensHelene MerleNadira KaddourBoris BertheSamir BekkhoucheKaouttar MelloukMélaine LebrazicCarole OuisseDiane MaugarsChristelle AparicioIgor TheodoseManal NouacerVeronique DeilerFariza LamaraMyriam MoussaAtika MouaciNassima ViguierWolters KluwerarticleMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENCritical Care Explorations, Vol 3, Iss 1, p e0329 (2021) |