Associations of Thyroid Hormone Levels and Macrovascular Complications in Euthyroid Type 2 Diabetic Patients

Yonghui Hu, Zhiyue Yan, Congqing Pan NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, People’s Republic of ChinaCorrespondence: Cong...

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Autores principales:	Hu Y, Yan Z, Pan C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	macrovascular complications t2dm thyroid hormone type 2 diabetes mellitus Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/79957531def94a77b139f176bfc52497
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spelling	oai:doaj.org-article:79957531def94a77b139f176bfc524972021-12-02T16:02:31ZAssociations of Thyroid Hormone Levels and Macrovascular Complications in Euthyroid Type 2 Diabetic Patients1178-7007https://doaj.org/article/79957531def94a77b139f176bfc524972021-06-01T00:00:00Zhttps://www.dovepress.com/associations-of-thyroid-hormone-levels-and-macrovascular-complications-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Yonghui Hu, Zhiyue Yan, Congqing Pan NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, People’s Republic of ChinaCorrespondence: Congqing PanNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, People’s Republic of ChinaTel +86-13920423976Fax +86-22-59560475Email profpancq@163.comPurpose: The purpose of this study is to evaluate whether thyroid hormone in euthyroid patients with type 2 diabetes mellitus (T2DM) is associated with macrovascular complications.Patients and Methods: The authors examined 311 patients enrolled from February 2019 to December 2019 in Tianjin Medical University Chu Hsien-I Memorial Hospital. A medical record review enabled the collection of demographic and anthropometric information. We classified the patients into two groups based on the echocardiography and vascular ultrasonography results, namely, non-macrovascular complications (n=131) group and macrovascular complications (n=180) group. Odds ratios (OR) and 95% confidence intervals (CI) were calculated, adjusting for potential confounders, the prevalence of macrovascular complications was determined using multivariate logistic regression.Results: A significant association was observed for diabetic macrovascular complications with normal free triiodothyronine (FT3) (OR=0.534, 95% CI 0.358– 0.796, p = 0.002) and free thyroxine (FT4) (OR= 0.844, 95% CI 0.760– 0.937, p = 0.001). Nevertheless, there was no evidence of any association between thyroid-stimulating hormone (TSH) and the development of diabetic macrovascular complications. When stratified by the body mass index (BMI), a similar relationship existed with the overall results. The positive association remained in restricted analyses involving only patients with HbA1c abnormalities.Conclusion: Overweight or obese T2DM patients are at high risk due to the implicit association between low but clinically normal thyroid hormone levels and elevated risk of macrovascular complications. However, there were no statistically significant associations between TSH and diabetic macrovascular complications.Keywords: macrovascular complications, T2DM, thyroid hormone, type 2 diabetes mellitusHu YYan ZPan CDove Medical Pressarticlemacrovascular complicationst2dmthyroid hormonetype 2 diabetes mellitusSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 2683-2691 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	macrovascular complications t2dm thyroid hormone type 2 diabetes mellitus Specialties of internal medicine RC581-951
spellingShingle	macrovascular complications t2dm thyroid hormone type 2 diabetes mellitus Specialties of internal medicine RC581-951 Hu Y Yan Z Pan C Associations of Thyroid Hormone Levels and Macrovascular Complications in Euthyroid Type 2 Diabetic Patients
description	Yonghui Hu, Zhiyue Yan, Congqing Pan NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, People’s Republic of ChinaCorrespondence: Congqing PanNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, People’s Republic of ChinaTel +86-13920423976Fax +86-22-59560475Email profpancq@163.comPurpose: The purpose of this study is to evaluate whether thyroid hormone in euthyroid patients with type 2 diabetes mellitus (T2DM) is associated with macrovascular complications.Patients and Methods: The authors examined 311 patients enrolled from February 2019 to December 2019 in Tianjin Medical University Chu Hsien-I Memorial Hospital. A medical record review enabled the collection of demographic and anthropometric information. We classified the patients into two groups based on the echocardiography and vascular ultrasonography results, namely, non-macrovascular complications (n=131) group and macrovascular complications (n=180) group. Odds ratios (OR) and 95% confidence intervals (CI) were calculated, adjusting for potential confounders, the prevalence of macrovascular complications was determined using multivariate logistic regression.Results: A significant association was observed for diabetic macrovascular complications with normal free triiodothyronine (FT3) (OR=0.534, 95% CI 0.358– 0.796, p = 0.002) and free thyroxine (FT4) (OR= 0.844, 95% CI 0.760– 0.937, p = 0.001). Nevertheless, there was no evidence of any association between thyroid-stimulating hormone (TSH) and the development of diabetic macrovascular complications. When stratified by the body mass index (BMI), a similar relationship existed with the overall results. The positive association remained in restricted analyses involving only patients with HbA1c abnormalities.Conclusion: Overweight or obese T2DM patients are at high risk due to the implicit association between low but clinically normal thyroid hormone levels and elevated risk of macrovascular complications. However, there were no statistically significant associations between TSH and diabetic macrovascular complications.Keywords: macrovascular complications, T2DM, thyroid hormone, type 2 diabetes mellitus
format	article
author	Hu Y Yan Z Pan C
author_facet	Hu Y Yan Z Pan C
author_sort	Hu Y
title	Associations of Thyroid Hormone Levels and Macrovascular Complications in Euthyroid Type 2 Diabetic Patients
title_short	Associations of Thyroid Hormone Levels and Macrovascular Complications in Euthyroid Type 2 Diabetic Patients
title_full	Associations of Thyroid Hormone Levels and Macrovascular Complications in Euthyroid Type 2 Diabetic Patients
title_fullStr	Associations of Thyroid Hormone Levels and Macrovascular Complications in Euthyroid Type 2 Diabetic Patients
title_full_unstemmed	Associations of Thyroid Hormone Levels and Macrovascular Complications in Euthyroid Type 2 Diabetic Patients
title_sort	associations of thyroid hormone levels and macrovascular complications in euthyroid type 2 diabetic patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/79957531def94a77b139f176bfc52497
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Associations of Thyroid Hormone Levels and Macrovascular Complications in Euthyroid Type 2 Diabetic Patients

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