Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization

Azadeh Asefnejad1, Aliasghar Behnamghader2, Mohammad Taghi Khorasani3, Babak Farsadzadeh11Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran; 2Materials and Energy Research Center, Tehran, Iran; 3Iran Polymer and Petrochemical Institute, Tehran,...

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Autores principales:	Azadeh Asefnejad, Aliasghar Behnamghader, Mohammad Taghi Khorasani, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7996327611fe4d6b81252e981ffa0fc6
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spelling	oai:doaj.org-article:7996327611fe4d6b81252e981ffa0fc62021-12-02T03:00:39ZPolyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization1176-91141178-2013https://doaj.org/article/7996327611fe4d6b81252e981ffa0fc62011-01-01T00:00:00Zhttp://www.dovepress.com/polyurethanefluor-hydroxyapatite-nanocomposite-scaffolds-for-bone-tiss-a5996https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Azadeh Asefnejad1, Aliasghar Behnamghader2, Mohammad Taghi Khorasani3, Babak Farsadzadeh11Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran; 2Materials and Energy Research Center, Tehran, Iran; 3Iran Polymer and Petrochemical Institute, Tehran, IranAbstract: In this study, new nano-fluor-hydroxyapatite (nFHA)/polyurethane composite scaffolds were fabricated for potential use in bone tissue engineering. Polyester urethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and 1,4-butanediol as chain extender. Nano fluor-hydroxyapatite (nFHA) was successfully synthesized by sol-gel method. The solid&ndash;liquid phase separation and solvent sublimation methods were used for preparation of the porous composites. Mechanical properties, chemical structure, and morphological characteristics of the samples were investigated by compressive test, Fourier transform infrared, and scanning electron microscopy (SEM) techniques, respectively. The effect of nFHA powder content on porosity and pore morphology was investigated. SEM images demonstrated that the scaffolds were constituted of interconnected and homogeneously distributed pores. The pore size of the scaffolds was in the range 50&ndash;250 &micro;m. The result obtained in this research revealed that the porosity and pore average size decreased and compressive modulus increased with nFHA percentage. Considering morphological, physical, and mechanical properties, the scaffold with a higher ratio of nFHA has suitable potential use in tissue regeneration.Keywords: polyester urethane, composite, fluor-hydroxyapatite, scaffold Azadeh AsefnejadAliasghar BehnamghaderMohammad Taghi Khorasaniet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 93-100 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Azadeh Asefnejad Aliasghar Behnamghader Mohammad Taghi Khorasani et al Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization
description	Azadeh Asefnejad1, Aliasghar Behnamghader2, Mohammad Taghi Khorasani3, Babak Farsadzadeh11Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran; 2Materials and Energy Research Center, Tehran, Iran; 3Iran Polymer and Petrochemical Institute, Tehran, IranAbstract: In this study, new nano-fluor-hydroxyapatite (nFHA)/polyurethane composite scaffolds were fabricated for potential use in bone tissue engineering. Polyester urethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and 1,4-butanediol as chain extender. Nano fluor-hydroxyapatite (nFHA) was successfully synthesized by sol-gel method. The solid&ndash;liquid phase separation and solvent sublimation methods were used for preparation of the porous composites. Mechanical properties, chemical structure, and morphological characteristics of the samples were investigated by compressive test, Fourier transform infrared, and scanning electron microscopy (SEM) techniques, respectively. The effect of nFHA powder content on porosity and pore morphology was investigated. SEM images demonstrated that the scaffolds were constituted of interconnected and homogeneously distributed pores. The pore size of the scaffolds was in the range 50&ndash;250 &micro;m. The result obtained in this research revealed that the porosity and pore average size decreased and compressive modulus increased with nFHA percentage. Considering morphological, physical, and mechanical properties, the scaffold with a higher ratio of nFHA has suitable potential use in tissue regeneration.Keywords: polyester urethane, composite, fluor-hydroxyapatite, scaffold
format	article
author	Azadeh Asefnejad Aliasghar Behnamghader Mohammad Taghi Khorasani et al
author_facet	Azadeh Asefnejad Aliasghar Behnamghader Mohammad Taghi Khorasani et al
author_sort	Azadeh Asefnejad
title	Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization
title_short	Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization
title_full	Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization
title_fullStr	Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization
title_full_unstemmed	Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization
title_sort	polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. part i: morphological, physical, and mechanical characterization
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/7996327611fe4d6b81252e981ffa0fc6
work_keys_str_mv	AT azadehasefnejad polyurethanefluorhydroxyapatitenanocompositescaffoldsforbonetissueengineeringpartimorphologicalphysicalandmechanicalcharacterization AT aliasgharbehnamghader polyurethanefluorhydroxyapatitenanocompositescaffoldsforbonetissueengineeringpartimorphologicalphysicalandmechanicalcharacterization AT mohammadtaghikhorasani polyurethanefluorhydroxyapatitenanocompositescaffoldsforbonetissueengineeringpartimorphologicalphysicalandmechanicalcharacterization AT etal polyurethanefluorhydroxyapatitenanocompositescaffoldsforbonetissueengineeringpartimorphologicalphysicalandmechanicalcharacterization
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Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization

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