CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking

Chloride intracellular channel (CLIC) 4 is an ion channel, localized in the cytoplasm, and first identified as an actin binding protein. Here, Chou et al.knockout CLIC4 in mice and observe tubulogenesis and renal proximal tubule dilation defects, which is caused by irregular actin and endosomal traf...

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Autores principales:	Szu-Yi Chou, Kuo-Shun Hsu, Wataru Otsu, Ya-Chu Hsu, Yun-Cin Luo, Celine Yeh, Syed S. Shehab, Jie Chen, Vincent Shieh, Guo-an He, Michael B. Marean, Diane Felsen, Aihao Ding, Dix P. Poppas, Jen-Zen Chuang, Ching-Hwa Sung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79963ebc449a4f9688cf9e04a58cb412
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spelling	oai:doaj.org-article:79963ebc449a4f9688cf9e04a58cb4122021-12-02T17:32:07ZCLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking10.1038/ncomms104122041-1723https://doaj.org/article/79963ebc449a4f9688cf9e04a58cb4122016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10412https://doaj.org/toc/2041-1723Chloride intracellular channel (CLIC) 4 is an ion channel, localized in the cytoplasm, and first identified as an actin binding protein. Here, Chou et al.knockout CLIC4 in mice and observe tubulogenesis and renal proximal tubule dilation defects, which is caused by irregular actin and endosomal trafficking.Szu-Yi ChouKuo-Shun HsuWataru OtsuYa-Chu HsuYun-Cin LuoCeline YehSyed S. ShehabJie ChenVincent ShiehGuo-an HeMichael B. MareanDiane FelsenAihao DingDix P. PoppasJen-Zen ChuangChing-Hwa SungNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Szu-Yi Chou Kuo-Shun Hsu Wataru Otsu Ya-Chu Hsu Yun-Cin Luo Celine Yeh Syed S. Shehab Jie Chen Vincent Shieh Guo-an He Michael B. Marean Diane Felsen Aihao Ding Dix P. Poppas Jen-Zen Chuang Ching-Hwa Sung CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking
description	Chloride intracellular channel (CLIC) 4 is an ion channel, localized in the cytoplasm, and first identified as an actin binding protein. Here, Chou et al.knockout CLIC4 in mice and observe tubulogenesis and renal proximal tubule dilation defects, which is caused by irregular actin and endosomal trafficking.
format	article
author	Szu-Yi Chou Kuo-Shun Hsu Wataru Otsu Ya-Chu Hsu Yun-Cin Luo Celine Yeh Syed S. Shehab Jie Chen Vincent Shieh Guo-an He Michael B. Marean Diane Felsen Aihao Ding Dix P. Poppas Jen-Zen Chuang Ching-Hwa Sung
author_facet	Szu-Yi Chou Kuo-Shun Hsu Wataru Otsu Ya-Chu Hsu Yun-Cin Luo Celine Yeh Syed S. Shehab Jie Chen Vincent Shieh Guo-an He Michael B. Marean Diane Felsen Aihao Ding Dix P. Poppas Jen-Zen Chuang Ching-Hwa Sung
author_sort	Szu-Yi Chou
title	CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking
title_short	CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking
title_full	CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking
title_fullStr	CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking
title_full_unstemmed	CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking
title_sort	clic4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/79963ebc449a4f9688cf9e04a58cb412
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CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking

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