EFFICACY OF METHOTREXATE IN THE MANAGEMENT OF LOCALLY ADVANCED AND METASTATIC HEAD AND NECK CANCERS

Objective: To evaluate the efficacy of single agent methotrexate in locally advanced and metastatic head and neck cancer. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Oncology, Combined Military Hospital (CMH), Rawalpindi from Jan 2017 to Jul 2017. Meth...

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Autores principales:	Meherullah Tareen, Ahsan Mahmood, Muhammad Yousaf Khan, Saifullah Tareen
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	head and neck cancer methotrexate Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/799670580d1b4cb5a2a4e55f56bcbd47
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spelling	oai:doaj.org-article:799670580d1b4cb5a2a4e55f56bcbd472021-11-08T02:53:20ZEFFICACY OF METHOTREXATE IN THE MANAGEMENT OF LOCALLY ADVANCED AND METASTATIC HEAD AND NECK CANCERS0030-96482411-8842https://doaj.org/article/799670580d1b4cb5a2a4e55f56bcbd472019-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3645/2466https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To evaluate the efficacy of single agent methotrexate in locally advanced and metastatic head and neck cancer. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Oncology, Combined Military Hospital (CMH), Rawalpindi from Jan 2017 to Jul 2017. Methodology: Fifty patients were enrolled with locally advanced or metastatic head and neck cancers, which were unfit for further treatment with curative radical surgery, radiotherapy and/or double agent chemotherapy. All the patients were treated with metronomic chemotherapy methotrexate 50mg weekly intravenously and the dose was escalated as tolerated up to a maximum of 200mg/week. Patients were followed up fortnightly for clinical response using Response Evaluation Criteria in Solid Tumors (RECIST). Imaging was performed on suspicion of progression. Results: Out of 50 patients, two (4%) patients have shown complete clinical response, 16 (32%) patient with partial response and 19 (38%) patients with stable disease. Disease progression was observed in 13 (26%) patients. Subset analyses revealed thirty-two (64%) patients with improvement in quality of life in terms of symptomatic control. Only 9 (18%) patients were observed with Grade 2 neutropenia, 4 (8%) patients with grade 2 anemia. Conclusion: Single agent methotrexate was an effective alternative regimen for patients with locally advanced or metastatic head and neck cancers.Meherullah TareenAhsan MahmoodMuhammad Yousaf KhanSaifullah TareenArmy Medical College Rawalpindiarticlehead and neck cancermethotrexateMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 6, Pp 1253-1257 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	head and neck cancer methotrexate Medicine R Medicine (General) R5-920
spellingShingle	head and neck cancer methotrexate Medicine R Medicine (General) R5-920 Meherullah Tareen Ahsan Mahmood Muhammad Yousaf Khan Saifullah Tareen EFFICACY OF METHOTREXATE IN THE MANAGEMENT OF LOCALLY ADVANCED AND METASTATIC HEAD AND NECK CANCERS
description	Objective: To evaluate the efficacy of single agent methotrexate in locally advanced and metastatic head and neck cancer. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Oncology, Combined Military Hospital (CMH), Rawalpindi from Jan 2017 to Jul 2017. Methodology: Fifty patients were enrolled with locally advanced or metastatic head and neck cancers, which were unfit for further treatment with curative radical surgery, radiotherapy and/or double agent chemotherapy. All the patients were treated with metronomic chemotherapy methotrexate 50mg weekly intravenously and the dose was escalated as tolerated up to a maximum of 200mg/week. Patients were followed up fortnightly for clinical response using Response Evaluation Criteria in Solid Tumors (RECIST). Imaging was performed on suspicion of progression. Results: Out of 50 patients, two (4%) patients have shown complete clinical response, 16 (32%) patient with partial response and 19 (38%) patients with stable disease. Disease progression was observed in 13 (26%) patients. Subset analyses revealed thirty-two (64%) patients with improvement in quality of life in terms of symptomatic control. Only 9 (18%) patients were observed with Grade 2 neutropenia, 4 (8%) patients with grade 2 anemia. Conclusion: Single agent methotrexate was an effective alternative regimen for patients with locally advanced or metastatic head and neck cancers.
format	article
author	Meherullah Tareen Ahsan Mahmood Muhammad Yousaf Khan Saifullah Tareen
author_facet	Meherullah Tareen Ahsan Mahmood Muhammad Yousaf Khan Saifullah Tareen
author_sort	Meherullah Tareen
title	EFFICACY OF METHOTREXATE IN THE MANAGEMENT OF LOCALLY ADVANCED AND METASTATIC HEAD AND NECK CANCERS
title_short	EFFICACY OF METHOTREXATE IN THE MANAGEMENT OF LOCALLY ADVANCED AND METASTATIC HEAD AND NECK CANCERS
title_full	EFFICACY OF METHOTREXATE IN THE MANAGEMENT OF LOCALLY ADVANCED AND METASTATIC HEAD AND NECK CANCERS
title_fullStr	EFFICACY OF METHOTREXATE IN THE MANAGEMENT OF LOCALLY ADVANCED AND METASTATIC HEAD AND NECK CANCERS
title_full_unstemmed	EFFICACY OF METHOTREXATE IN THE MANAGEMENT OF LOCALLY ADVANCED AND METASTATIC HEAD AND NECK CANCERS
title_sort	efficacy of methotrexate in the management of locally advanced and metastatic head and neck cancers
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/799670580d1b4cb5a2a4e55f56bcbd47
work_keys_str_mv	AT meherullahtareen efficacyofmethotrexateinthemanagementoflocallyadvancedandmetastaticheadandneckcancers AT ahsanmahmood efficacyofmethotrexateinthemanagementoflocallyadvancedandmetastaticheadandneckcancers AT muhammadyousafkhan efficacyofmethotrexateinthemanagementoflocallyadvancedandmetastaticheadandneckcancers AT saifullahtareen efficacyofmethotrexateinthemanagementoflocallyadvancedandmetastaticheadandneckcancers
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EFFICACY OF METHOTREXATE IN THE MANAGEMENT OF LOCALLY ADVANCED AND METASTATIC HEAD AND NECK CANCERS

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