Visual field loss in schizophrenia: evaluation of magnocellular pathway dysfunction in schizophrenic patients and their parents

Carolina Pelegrini Barbosa Gracitelli,1 Fabiana Benites Vaz de Lima,2,3 Rodrigo A Bressan,2,3 Augusto Paranhos Junior1 1Department of Ophthalmology, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil; 2LiNC – Interdisciplinary Laboratory of Neuroimaging...

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Autores principales:	Gracitelli CPB, Vaz de Lima FB, Bressan RA, Paranhos Jr A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7998211788234234a799f45e0b0e4ba6
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spelling	oai:doaj.org-article:7998211788234234a799f45e0b0e4ba62021-12-02T01:00:31ZVisual field loss in schizophrenia: evaluation of magnocellular pathway dysfunction in schizophrenic patients and their parents1177-54671177-5483https://doaj.org/article/7998211788234234a799f45e0b0e4ba62013-05-01T00:00:00Zhttp://www.dovepress.com/visual-field-loss-in-schizophrenia-evaluation-of-magnocellular-pathway-a13192https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Carolina Pelegrini Barbosa Gracitelli,1 Fabiana Benites Vaz de Lima,2,3 Rodrigo A Bressan,2,3 Augusto Paranhos Junior1 1Department of Ophthalmology, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil; 2LiNC – Interdisciplinary Laboratory of Neuroimaging and Cognition, Department of Psychiatry, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil; 3PROESQ – Schizophrenia Program, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil Purpose: We sought to evaluate the visual pathway deficits in schizophrenic patients, compared with their parents and healthy controls, using Matrix frequency doubling technology (FDT) perimetry. Matrix FDT is an ophthalmic test used to detect visual field loss. Method: A total of 13 patients, 13 parents, and 12 healthy controls were enrolled in the study. Participants were subjected to Matrix FDT perimetry in a single test session. We analyzed the mean deviation for each eye and used a generalized estimated equation to evaluate differences among the groups and correct the dependency between the eyes. Results: The global mean deviation (presented as the mean of both eyes) was significantly lower in the schizophrenic patients than in their parents or controls. Analysis of the general sensitivity of the fibers crossing the optic chiasm showed a difference between the groups (P = 0.006), indicating that the sensitivity of the fibers crossing the optic chiasm was lower than those which did not cross. But when we analyzed the specific groups, the difference between the fibers was not considerable. Comparison of the right and left hemispheres showed that general sensitivity was lower for the left hemisphere, but when we analyzed specific groups, the difference was not significant (P = 0.29). Conclusion: These findings are suggestive of a lower global sensitivity in schizophrenic patients and their parents compared with controls. This difference may be an endophenotype of schizophrenia. The present study adds to a growing body of research on early-stage visual processing deficits in schizophrenia. Keywords: schizophrenic patients, visual processing, endophenotype, frequency doubling technologyGracitelli CPBVaz de Lima FBBressan RAParanhos Jr ADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1015-1021 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Gracitelli CPB Vaz de Lima FB Bressan RA Paranhos Jr A Visual field loss in schizophrenia: evaluation of magnocellular pathway dysfunction in schizophrenic patients and their parents
description	Carolina Pelegrini Barbosa Gracitelli,1 Fabiana Benites Vaz de Lima,2,3 Rodrigo A Bressan,2,3 Augusto Paranhos Junior1 1Department of Ophthalmology, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil; 2LiNC – Interdisciplinary Laboratory of Neuroimaging and Cognition, Department of Psychiatry, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil; 3PROESQ – Schizophrenia Program, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil Purpose: We sought to evaluate the visual pathway deficits in schizophrenic patients, compared with their parents and healthy controls, using Matrix frequency doubling technology (FDT) perimetry. Matrix FDT is an ophthalmic test used to detect visual field loss. Method: A total of 13 patients, 13 parents, and 12 healthy controls were enrolled in the study. Participants were subjected to Matrix FDT perimetry in a single test session. We analyzed the mean deviation for each eye and used a generalized estimated equation to evaluate differences among the groups and correct the dependency between the eyes. Results: The global mean deviation (presented as the mean of both eyes) was significantly lower in the schizophrenic patients than in their parents or controls. Analysis of the general sensitivity of the fibers crossing the optic chiasm showed a difference between the groups (P = 0.006), indicating that the sensitivity of the fibers crossing the optic chiasm was lower than those which did not cross. But when we analyzed the specific groups, the difference between the fibers was not considerable. Comparison of the right and left hemispheres showed that general sensitivity was lower for the left hemisphere, but when we analyzed specific groups, the difference was not significant (P = 0.29). Conclusion: These findings are suggestive of a lower global sensitivity in schizophrenic patients and their parents compared with controls. This difference may be an endophenotype of schizophrenia. The present study adds to a growing body of research on early-stage visual processing deficits in schizophrenia. Keywords: schizophrenic patients, visual processing, endophenotype, frequency doubling technology
format	article
author	Gracitelli CPB Vaz de Lima FB Bressan RA Paranhos Jr A
author_facet	Gracitelli CPB Vaz de Lima FB Bressan RA Paranhos Jr A
author_sort	Gracitelli CPB
title	Visual field loss in schizophrenia: evaluation of magnocellular pathway dysfunction in schizophrenic patients and their parents
title_short	Visual field loss in schizophrenia: evaluation of magnocellular pathway dysfunction in schizophrenic patients and their parents
title_full	Visual field loss in schizophrenia: evaluation of magnocellular pathway dysfunction in schizophrenic patients and their parents
title_fullStr	Visual field loss in schizophrenia: evaluation of magnocellular pathway dysfunction in schizophrenic patients and their parents
title_full_unstemmed	Visual field loss in schizophrenia: evaluation of magnocellular pathway dysfunction in schizophrenic patients and their parents
title_sort	visual field loss in schizophrenia: evaluation of magnocellular pathway dysfunction in schizophrenic patients and their parents
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/7998211788234234a799f45e0b0e4ba6
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_version_	1718403394176024576

Visual field loss in schizophrenia: evaluation of magnocellular pathway dysfunction in schizophrenic patients and their parents

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