Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling

Prenatal exposure to environmental stressors is known to impair cortical development. Here the authors show that upon exposure to stressors, the activation of Hsf1-Hsp signalling is highly variable among cells in the embryonic cortex of mice, and either too much or too little activation can result i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Seiji Ishii, Masaaki Torii, Alexander I. Son, Meenu Rajendraprasad, Yury M. Morozov, Yuka Imamura Kawasawa, Anna C. Salzberg, Mitsuaki Fujimoto, Kristen Brennand, Akira Nakai, Valerie Mezger, Fred H. Gage, Pasko Rakic, Kazue Hashimoto-Torii
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/799a96f9df824be3a9794751c745b994
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:799a96f9df824be3a9794751c745b994
record_format	dspace
spelling	oai:doaj.org-article:799a96f9df824be3a9794751c745b9942021-12-02T15:37:05ZVariations in brain defects result from cellular mosaicism in the activation of heat shock signalling10.1038/ncomms151572041-1723https://doaj.org/article/799a96f9df824be3a9794751c745b9942017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15157https://doaj.org/toc/2041-1723Prenatal exposure to environmental stressors is known to impair cortical development. Here the authors show that upon exposure to stressors, the activation of Hsf1-Hsp signalling is highly variable among cells in the embryonic cortex of mice, and either too much or too little activation can result in defects in cortical development.Seiji IshiiMasaaki ToriiAlexander I. SonMeenu RajendraprasadYury M. MorozovYuka Imamura KawasawaAnna C. SalzbergMitsuaki FujimotoKristen BrennandAkira NakaiValerie MezgerFred H. GagePasko RakicKazue Hashimoto-ToriiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seiji Ishii Masaaki Torii Alexander I. Son Meenu Rajendraprasad Yury M. Morozov Yuka Imamura Kawasawa Anna C. Salzberg Mitsuaki Fujimoto Kristen Brennand Akira Nakai Valerie Mezger Fred H. Gage Pasko Rakic Kazue Hashimoto-Torii Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling
description	Prenatal exposure to environmental stressors is known to impair cortical development. Here the authors show that upon exposure to stressors, the activation of Hsf1-Hsp signalling is highly variable among cells in the embryonic cortex of mice, and either too much or too little activation can result in defects in cortical development.
format	article
author	Seiji Ishii Masaaki Torii Alexander I. Son Meenu Rajendraprasad Yury M. Morozov Yuka Imamura Kawasawa Anna C. Salzberg Mitsuaki Fujimoto Kristen Brennand Akira Nakai Valerie Mezger Fred H. Gage Pasko Rakic Kazue Hashimoto-Torii
author_facet	Seiji Ishii Masaaki Torii Alexander I. Son Meenu Rajendraprasad Yury M. Morozov Yuka Imamura Kawasawa Anna C. Salzberg Mitsuaki Fujimoto Kristen Brennand Akira Nakai Valerie Mezger Fred H. Gage Pasko Rakic Kazue Hashimoto-Torii
author_sort	Seiji Ishii
title	Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling
title_short	Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling
title_full	Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling
title_fullStr	Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling
title_full_unstemmed	Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling
title_sort	variations in brain defects result from cellular mosaicism in the activation of heat shock signalling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/799a96f9df824be3a9794751c745b994
work_keys_str_mv	AT seijiishii variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT masaakitorii variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT alexanderison variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT meenurajendraprasad variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT yurymmorozov variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT yukaimamurakawasawa variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT annacsalzberg variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT mitsuakifujimoto variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT kristenbrennand variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT akiranakai variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT valeriemezger variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT fredhgage variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT paskorakic variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling AT kazuehashimototorii variationsinbraindefectsresultfromcellularmosaicismintheactivationofheatshocksignalling
_version_	1718386241508999168

Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling

Ejemplares similares