Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling

Prenatal exposure to environmental stressors is known to impair cortical development. Here the authors show that upon exposure to stressors, the activation of Hsf1-Hsp signalling is highly variable among cells in the embryonic cortex of mice, and either too much or too little activation can result i...

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Autores principales: Seiji Ishii, Masaaki Torii, Alexander I. Son, Meenu Rajendraprasad, Yury M. Morozov, Yuka Imamura Kawasawa, Anna C. Salzberg, Mitsuaki Fujimoto, Kristen Brennand, Akira Nakai, Valerie Mezger, Fred H. Gage, Pasko Rakic, Kazue Hashimoto-Torii
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/799a96f9df824be3a9794751c745b994
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