Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting

Aleksandra Szylińska,1 Mariusz J Listewnik,2 Iwona Rotter,1 Aleksandra Rył,3 Andrzej Biskupski,2 Mirosław Brykczyński2 1Department of Medical Rehabilitation, 2Department of Cardiac Surgery, 3Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland...

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Autores principales:	Szylińska A, Listewnik MJ, Rotter I, Rył A, Biskupski A, Brykczyński M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	spirometry C-reactive protein coronary artery bypass graft (CABG) Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/799f0868e47145bd9497695f20c551d3
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spelling	oai:doaj.org-article:799f0868e47145bd9497695f20c551d32021-12-02T08:24:24ZAnalysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting1178-1998https://doaj.org/article/799f0868e47145bd9497695f20c551d32017-07-01T00:00:00Zhttps://www.dovepress.com/analysis-of-the-influence-of-respiratory-disorders-observed-in-preoper-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Aleksandra Szylińska,1 Mariusz J Listewnik,2 Iwona Rotter,1 Aleksandra Rył,3 Andrzej Biskupski,2 Mirosław Brykczyński2 1Department of Medical Rehabilitation, 2Department of Cardiac Surgery, 3Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland Background: Preoperative spirometry provides measurable information about the occurrence of respiratory disorders. The aim of this study was to assess the association between preoperative spirometry abnormalities and the intensification of early inflammatory responses in patients following coronary artery bypass graft in extracorporeal circulation. Material and methods: The study involved 810 patients (625 men and 185 women) aged 65.4±7.9 years who were awaiting isolated coronary artery bypass surgery. On the basis of spirometry performed on the day of admittance to the hospital, the patients were divided into three groups. Patients without respiratory problems constituted 78.8% of the entire group. Restricted breathing was revealed by spirometry in 14.9% and obstructive breathing in 6.3% of patients. Results: Inter-group analysis showed statistically significant differences in C-reactive protein (CRP) between patients with restrictive spirometry abnormalities and patients without any pulmonary dysfunction. CRP concentrations differed before surgery (P=0.006) and on the second (P<0.001), fourth (P=0.005) and sixth days after surgery (P=0.029). There was a negative correlation between CRP levels and FEV1. Conclusion: In our study, the most common pulmonary disorders in the coronary artery bypass graft patients were restrictive. Patients with abnormal spirometry results from restrictive respiratory disorders have an elevated level of generalized inflammatory response both before and after the isolated coronary artery bypass surgery. Therefore, this group of patients should be given special postoperative monitoring and, in particular, intensive respiratory rehabilitation immediately after reconstitution. Keywords: pulmonary function, C-reactive protein, cardiac surgerySzylińska AListewnik MJRotter IRył ABiskupski ABrykczyński MDove Medical PressarticlespirometryC-reactive proteincoronary artery bypass graft (CABG)GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1123-1129 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	spirometry C-reactive protein coronary artery bypass graft (CABG) Geriatrics RC952-954.6
spellingShingle	spirometry C-reactive protein coronary artery bypass graft (CABG) Geriatrics RC952-954.6 Szylińska A Listewnik MJ Rotter I Rył A Biskupski A Brykczyński M Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting
description	Aleksandra Szylińska,1 Mariusz J Listewnik,2 Iwona Rotter,1 Aleksandra Rył,3 Andrzej Biskupski,2 Mirosław Brykczyński2 1Department of Medical Rehabilitation, 2Department of Cardiac Surgery, 3Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland Background: Preoperative spirometry provides measurable information about the occurrence of respiratory disorders. The aim of this study was to assess the association between preoperative spirometry abnormalities and the intensification of early inflammatory responses in patients following coronary artery bypass graft in extracorporeal circulation. Material and methods: The study involved 810 patients (625 men and 185 women) aged 65.4±7.9 years who were awaiting isolated coronary artery bypass surgery. On the basis of spirometry performed on the day of admittance to the hospital, the patients were divided into three groups. Patients without respiratory problems constituted 78.8% of the entire group. Restricted breathing was revealed by spirometry in 14.9% and obstructive breathing in 6.3% of patients. Results: Inter-group analysis showed statistically significant differences in C-reactive protein (CRP) between patients with restrictive spirometry abnormalities and patients without any pulmonary dysfunction. CRP concentrations differed before surgery (P=0.006) and on the second (P<0.001), fourth (P=0.005) and sixth days after surgery (P=0.029). There was a negative correlation between CRP levels and FEV1. Conclusion: In our study, the most common pulmonary disorders in the coronary artery bypass graft patients were restrictive. Patients with abnormal spirometry results from restrictive respiratory disorders have an elevated level of generalized inflammatory response both before and after the isolated coronary artery bypass surgery. Therefore, this group of patients should be given special postoperative monitoring and, in particular, intensive respiratory rehabilitation immediately after reconstitution. Keywords: pulmonary function, C-reactive protein, cardiac surgery
format	article
author	Szylińska A Listewnik MJ Rotter I Rył A Biskupski A Brykczyński M
author_facet	Szylińska A Listewnik MJ Rotter I Rył A Biskupski A Brykczyński M
author_sort	Szylińska A
title	Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting
title_short	Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting
title_full	Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting
title_fullStr	Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting
title_full_unstemmed	Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting
title_sort	analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/799f0868e47145bd9497695f20c551d3
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Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting

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