Graphene microfiber as a scaffold for regulation of neural stem cells differentiation

Abstract We report the cytocompatibility and regulating effects of the nanostructured reduced graphene oxide (rGO) microfibers, which are synthesized through a capillary hydrothermal method, on neural differentiation of neural stem cells (NSCs). Our findings indicate that the flexible, mechanically...

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Autores principales:	Weibo Guo, Jichuan Qiu, Jingquan Liu, Hong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/79a2698081fe434baef6ba6b647f3bcb
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spelling	oai:doaj.org-article:79a2698081fe434baef6ba6b647f3bcb2021-12-02T11:52:43ZGraphene microfiber as a scaffold for regulation of neural stem cells differentiation10.1038/s41598-017-06051-z2045-2322https://doaj.org/article/79a2698081fe434baef6ba6b647f3bcb2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06051-zhttps://doaj.org/toc/2045-2322Abstract We report the cytocompatibility and regulating effects of the nanostructured reduced graphene oxide (rGO) microfibers, which are synthesized through a capillary hydrothermal method, on neural differentiation of neural stem cells (NSCs). Our findings indicate that the flexible, mechanically strong, surface nanoporous, biodegradable, and cytocompatible nanostructured rGO microfibers not only offer a more powerful substrate for NSCs adhesion and proliferation compared with 2D graphene film and tissue cluture plate but also regulate the NSCs differentiation into neurons and form a dense neural network surrounding the microfiber. These results illustrate the great potential of nanostructured rGO microfibers as an artificial neural tissue engineering (NTE) scaffold for nerve regeneration.Weibo GuoJichuan QiuJingquan LiuHong LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Weibo Guo Jichuan Qiu Jingquan Liu Hong Liu Graphene microfiber as a scaffold for regulation of neural stem cells differentiation
description	Abstract We report the cytocompatibility and regulating effects of the nanostructured reduced graphene oxide (rGO) microfibers, which are synthesized through a capillary hydrothermal method, on neural differentiation of neural stem cells (NSCs). Our findings indicate that the flexible, mechanically strong, surface nanoporous, biodegradable, and cytocompatible nanostructured rGO microfibers not only offer a more powerful substrate for NSCs adhesion and proliferation compared with 2D graphene film and tissue cluture plate but also regulate the NSCs differentiation into neurons and form a dense neural network surrounding the microfiber. These results illustrate the great potential of nanostructured rGO microfibers as an artificial neural tissue engineering (NTE) scaffold for nerve regeneration.
format	article
author	Weibo Guo Jichuan Qiu Jingquan Liu Hong Liu
author_facet	Weibo Guo Jichuan Qiu Jingquan Liu Hong Liu
author_sort	Weibo Guo
title	Graphene microfiber as a scaffold for regulation of neural stem cells differentiation
title_short	Graphene microfiber as a scaffold for regulation of neural stem cells differentiation
title_full	Graphene microfiber as a scaffold for regulation of neural stem cells differentiation
title_fullStr	Graphene microfiber as a scaffold for regulation of neural stem cells differentiation
title_full_unstemmed	Graphene microfiber as a scaffold for regulation of neural stem cells differentiation
title_sort	graphene microfiber as a scaffold for regulation of neural stem cells differentiation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/79a2698081fe434baef6ba6b647f3bcb
work_keys_str_mv	AT weiboguo graphenemicrofiberasascaffoldforregulationofneuralstemcellsdifferentiation AT jichuanqiu graphenemicrofiberasascaffoldforregulationofneuralstemcellsdifferentiation AT jingquanliu graphenemicrofiberasascaffoldforregulationofneuralstemcellsdifferentiation AT hongliu graphenemicrofiberasascaffoldforregulationofneuralstemcellsdifferentiation
_version_	1718394934671704064

Graphene microfiber as a scaffold for regulation of neural stem cells differentiation

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