High-grade glioma in elderly patients: can the oncogeriatrician help?

Emeline Tabouret,1 Louis Tassy,2 Olivier Chinot,1 ElodieCrétel,3 Frederique Retornaz,4 Frederique Rousseau5 1Department of Neuro-oncology, Timone Hospital, Marseille, France; 2Department of Medical Oncology, Centre Léon Bérard, Lyon, France; 3Transveral Oncogeriatric...

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Autores principales:	Tabouret E, Tassy L, Chinot O, Crétel E, Retornaz F, Rousseau F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	brain tumor older cancer patient chemotherapy toxicity oncogeriatric charter Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/79a63ad12ea7411f99c295d6d9f55052
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spelling	oai:doaj.org-article:79a63ad12ea7411f99c295d6d9f550522021-12-02T07:35:31ZHigh-grade glioma in elderly patients: can the oncogeriatrician help?1178-1998https://doaj.org/article/79a63ad12ea7411f99c295d6d9f550522013-12-01T00:00:00Zhttps://www.dovepress.com/high-grade-glioma-in-elderly-patients-can-the-oncogeriatrician-help-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Emeline Tabouret,1 Louis Tassy,2 Olivier Chinot,1 ElodieCrétel,3 Frederique Retornaz,4 Frederique Rousseau5 1Department of Neuro-oncology, Timone Hospital, Marseille, France; 2Department of Medical Oncology, Centre Léon Bérard, Lyon, France; 3Transveral Oncogeriatric Unit, University Hospital Timone, Marseille, France; 4Departmental Gerontologic Center, Marseille, France; 5Department of Medical Oncology, Institut Paoli Calmettes, Marseille, France Abstract: Gliomas are the most frequent primary brain tumors in adults. As the population ages in Western countries, the number of people being diagnosed with glioblastoma is expected to increase. Clinical management of elderly patients with primary brain tumors is difficult, owing to multiple comorbidities, polypharmacy, decreased tolerance to chemotherapy, and an increased risk of radiation-induced neurotoxicity. A few specific randomized studies have shown a benefit for radiotherapy in elderly patients with good performance status. For patients with poor performance status, chemotherapy (temozolomide) has been shown to be associated with prolonged duration of response. Patients with methylated O6-alkylguanine deoxyribonucleic acid alkyltransferase promoter seem to have better outcomes. Oncogeriatrics proposes the geriatric evaluation of elderly patients to improve therapeutic choices and optimize the management of treatment toxicities and comorbidities. Keywords: brain tumor, older cancer patient, chemotherapy toxicity, oncogeriatric charterTabouret ETassy LChinot OCrétel ERetornaz FRousseau FDove Medical Pressarticlebrain tumorolder cancer patientchemotherapy toxicityoncogeriatric charterGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 1617-1624 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain tumor older cancer patient chemotherapy toxicity oncogeriatric charter Geriatrics RC952-954.6
spellingShingle	brain tumor older cancer patient chemotherapy toxicity oncogeriatric charter Geriatrics RC952-954.6 Tabouret E Tassy L Chinot O Crétel E Retornaz F Rousseau F High-grade glioma in elderly patients: can the oncogeriatrician help?
description	Emeline Tabouret,1 Louis Tassy,2 Olivier Chinot,1 ElodieCrétel,3 Frederique Retornaz,4 Frederique Rousseau5 1Department of Neuro-oncology, Timone Hospital, Marseille, France; 2Department of Medical Oncology, Centre Léon Bérard, Lyon, France; 3Transveral Oncogeriatric Unit, University Hospital Timone, Marseille, France; 4Departmental Gerontologic Center, Marseille, France; 5Department of Medical Oncology, Institut Paoli Calmettes, Marseille, France Abstract: Gliomas are the most frequent primary brain tumors in adults. As the population ages in Western countries, the number of people being diagnosed with glioblastoma is expected to increase. Clinical management of elderly patients with primary brain tumors is difficult, owing to multiple comorbidities, polypharmacy, decreased tolerance to chemotherapy, and an increased risk of radiation-induced neurotoxicity. A few specific randomized studies have shown a benefit for radiotherapy in elderly patients with good performance status. For patients with poor performance status, chemotherapy (temozolomide) has been shown to be associated with prolonged duration of response. Patients with methylated O6-alkylguanine deoxyribonucleic acid alkyltransferase promoter seem to have better outcomes. Oncogeriatrics proposes the geriatric evaluation of elderly patients to improve therapeutic choices and optimize the management of treatment toxicities and comorbidities. Keywords: brain tumor, older cancer patient, chemotherapy toxicity, oncogeriatric charter
format	article
author	Tabouret E Tassy L Chinot O Crétel E Retornaz F Rousseau F
author_facet	Tabouret E Tassy L Chinot O Crétel E Retornaz F Rousseau F
author_sort	Tabouret E
title	High-grade glioma in elderly patients: can the oncogeriatrician help?
title_short	High-grade glioma in elderly patients: can the oncogeriatrician help?
title_full	High-grade glioma in elderly patients: can the oncogeriatrician help?
title_fullStr	High-grade glioma in elderly patients: can the oncogeriatrician help?
title_full_unstemmed	High-grade glioma in elderly patients: can the oncogeriatrician help?
title_sort	high-grade glioma in elderly patients: can the oncogeriatrician help?
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/79a63ad12ea7411f99c295d6d9f55052
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High-grade glioma in elderly patients: can the oncogeriatrician help?

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