Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort.

The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different epidemic periods. Prospective, observational, cohort study of hospitalized COVID-19. A total of 421 consecutive patients were included, 188 during the first period (Marc...

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Autores principales:	María Zuil, Iván D Benítez, Ramón Cabo-Gambín, Carlos Manzano Senra, Anna Moncusí-Moix, Clara Gort-Paniello, David de Gonzalo-Calvo, Marta Molinero, Jose Javier Vengoechea Aragoncillo, Thais Comella, Jordi de Batlle, Gerard Torres, Antoni Torres, Ferrán Barbé, Jessica González
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/79a64161a82845c38075ca2f67b344cd
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spelling	oai:doaj.org-article:79a64161a82845c38075ca2f67b344cd2021-12-02T20:13:24ZClinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort.1932-620310.1371/journal.pone.0258918https://doaj.org/article/79a64161a82845c38075ca2f67b344cd2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258918https://doaj.org/toc/1932-6203The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different epidemic periods. Prospective, observational, cohort study of hospitalized COVID-19. A total of 421 consecutive patients were included, 188 during the first period (March-May 2020) and 233 in the second wave (July-December 2020). Clinical, epidemiological, prognostic and therapeutic data were compared. Patients of the first outbreak were older and more comorbid, presented worse PaO2/FiO2 ratio and an increased creatinine and D-dimer levels at hospital admission. The hospital stay was shorter (14.5[8;29] vs 8[6;14] days, p<0.001), ICU admissions (31.9% vs 13.3%, p<0.001) and the number of patients who required mechanical ventilation (OR = 0.12 [0.05-10.26]; p<0.001) were reduced. There were no significant differences in hospital and 30-day after discharge mortality (adjusted HR = 1.56; p = 0.1056) or hospital readmissions. New treatments and clinical strategies appear to improve hospital length, ICU admissions and the requirement for mechanical ventilation. However, we did not observe differences in mortality or readmissions.María ZuilIván D BenítezRamón Cabo-GambínCarlos Manzano SenraAnna Moncusí-MoixClara Gort-PanielloDavid de Gonzalo-CalvoMarta MolineroJose Javier Vengoechea AragoncilloThais ComellaJordi de BatlleGerard TorresAntoni TorresFerrán BarbéJessica GonzálezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258918 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q María Zuil Iván D Benítez Ramón Cabo-Gambín Carlos Manzano Senra Anna Moncusí-Moix Clara Gort-Paniello David de Gonzalo-Calvo Marta Molinero Jose Javier Vengoechea Aragoncillo Thais Comella Jordi de Batlle Gerard Torres Antoni Torres Ferrán Barbé Jessica González Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort.
description	The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different epidemic periods. Prospective, observational, cohort study of hospitalized COVID-19. A total of 421 consecutive patients were included, 188 during the first period (March-May 2020) and 233 in the second wave (July-December 2020). Clinical, epidemiological, prognostic and therapeutic data were compared. Patients of the first outbreak were older and more comorbid, presented worse PaO2/FiO2 ratio and an increased creatinine and D-dimer levels at hospital admission. The hospital stay was shorter (14.5[8;29] vs 8[6;14] days, p<0.001), ICU admissions (31.9% vs 13.3%, p<0.001) and the number of patients who required mechanical ventilation (OR = 0.12 [0.05-10.26]; p<0.001) were reduced. There were no significant differences in hospital and 30-day after discharge mortality (adjusted HR = 1.56; p = 0.1056) or hospital readmissions. New treatments and clinical strategies appear to improve hospital length, ICU admissions and the requirement for mechanical ventilation. However, we did not observe differences in mortality or readmissions.
format	article
author	María Zuil Iván D Benítez Ramón Cabo-Gambín Carlos Manzano Senra Anna Moncusí-Moix Clara Gort-Paniello David de Gonzalo-Calvo Marta Molinero Jose Javier Vengoechea Aragoncillo Thais Comella Jordi de Batlle Gerard Torres Antoni Torres Ferrán Barbé Jessica González
author_facet	María Zuil Iván D Benítez Ramón Cabo-Gambín Carlos Manzano Senra Anna Moncusí-Moix Clara Gort-Paniello David de Gonzalo-Calvo Marta Molinero Jose Javier Vengoechea Aragoncillo Thais Comella Jordi de Batlle Gerard Torres Antoni Torres Ferrán Barbé Jessica González
author_sort	María Zuil
title	Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort.
title_short	Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort.
title_full	Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort.
title_fullStr	Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort.
title_full_unstemmed	Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort.
title_sort	clinical management and outcome differences between first and second waves among covid-19 hospitalized patients: a regional prospective observational cohort.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/79a64161a82845c38075ca2f67b344cd
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Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort.

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