9-cis retinoic acid induces neurorepair in stroke brain

Abstract The purpose of this study was to examine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke. Adult male rats received a 90-min right distal middle cerebral artery occlusion (dMCAo). Animals were separated into two groups with similar infarction sizes, bas...

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Autores principales:	Seong-Jin Yu, Mikko Airavaara, Kuo-Jen Wu, Brandon K Harvey, H. S. Liu, Yihong Yang, Alex Zacharek, Jieli Chen, Yun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/79abf83dca8640fdaeecc14b1ddbdfe9
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spelling	oai:doaj.org-article:79abf83dca8640fdaeecc14b1ddbdfe92021-12-02T15:05:16Z9-cis retinoic acid induces neurorepair in stroke brain10.1038/s41598-017-04048-22045-2322https://doaj.org/article/79abf83dca8640fdaeecc14b1ddbdfe92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04048-2https://doaj.org/toc/2045-2322Abstract The purpose of this study was to examine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke. Adult male rats received a 90-min right distal middle cerebral artery occlusion (dMCAo). Animals were separated into two groups with similar infarction sizes, based on magnetic resonance imaging on day 2 after dMCAo. 9cRA or vehicle was given via an intranasal route daily starting from day 3. Stroke rats receiving 9cRA post-treatment showed an increase in brain 9cRA levels and greater recovery in motor function. 9cRA enhanced the proliferation of bromodeoxyuridine (+) cells in the subventricular zone (SVZ) and lesioned cortex in the stroke brain. Using subventricular neurosphere and matrigel cultures, we demonstrated that proliferation and migration of SVZ neuroprogenitor cells were enhanced by 9cRA. Our data support a delayed and non-invasive drug therapy for stroke. Intranasal 9cRA can facilitate the functional recovery and endogenous repair in the ischemic brain.Seong-Jin YuMikko AiravaaraKuo-Jen WuBrandon K HarveyH. S. LiuYihong YangAlex ZacharekJieli ChenYun WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seong-Jin Yu Mikko Airavaara Kuo-Jen Wu Brandon K Harvey H. S. Liu Yihong Yang Alex Zacharek Jieli Chen Yun Wang 9-cis retinoic acid induces neurorepair in stroke brain
description	Abstract The purpose of this study was to examine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke. Adult male rats received a 90-min right distal middle cerebral artery occlusion (dMCAo). Animals were separated into two groups with similar infarction sizes, based on magnetic resonance imaging on day 2 after dMCAo. 9cRA or vehicle was given via an intranasal route daily starting from day 3. Stroke rats receiving 9cRA post-treatment showed an increase in brain 9cRA levels and greater recovery in motor function. 9cRA enhanced the proliferation of bromodeoxyuridine (+) cells in the subventricular zone (SVZ) and lesioned cortex in the stroke brain. Using subventricular neurosphere and matrigel cultures, we demonstrated that proliferation and migration of SVZ neuroprogenitor cells were enhanced by 9cRA. Our data support a delayed and non-invasive drug therapy for stroke. Intranasal 9cRA can facilitate the functional recovery and endogenous repair in the ischemic brain.
format	article
author	Seong-Jin Yu Mikko Airavaara Kuo-Jen Wu Brandon K Harvey H. S. Liu Yihong Yang Alex Zacharek Jieli Chen Yun Wang
author_facet	Seong-Jin Yu Mikko Airavaara Kuo-Jen Wu Brandon K Harvey H. S. Liu Yihong Yang Alex Zacharek Jieli Chen Yun Wang
author_sort	Seong-Jin Yu
title	9-cis retinoic acid induces neurorepair in stroke brain
title_short	9-cis retinoic acid induces neurorepair in stroke brain
title_full	9-cis retinoic acid induces neurorepair in stroke brain
title_fullStr	9-cis retinoic acid induces neurorepair in stroke brain
title_full_unstemmed	9-cis retinoic acid induces neurorepair in stroke brain
title_sort	9-cis retinoic acid induces neurorepair in stroke brain
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/79abf83dca8640fdaeecc14b1ddbdfe9
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9-cis retinoic acid induces neurorepair in stroke brain

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