Three-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration

Three-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration

Lena Rung,1 Monica Lövestam-Adrian21Department of Ophthalmology, Helsingborg Hospital, Helsingborg, 2Department of Ophthalmology, Lund University, Skåne University Hospital, Malmö, SwedenBackground: The purpose of this study was to evaluate the visual outcome...

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Autores principales: Rung L, Lövestam-Adrian M
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/79aca22bb5204b1db10fa4db528d364a
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spelling oai:doaj.org-article:79aca22bb5204b1db10fa4db528d364a2021-12-02T02:53:43ZThree-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration1177-54671177-5483https://doaj.org/article/79aca22bb5204b1db10fa4db528d364a2013-02-01T00:00:00Zhttp://www.dovepress.com/three-year-follow-up-of-visual-outcome-and-quality-of-life-in-patients-a12309https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Lena Rung,1 Monica Lövestam-Adrian21Department of Ophthalmology, Helsingborg Hospital, Helsingborg, 2Department of Ophthalmology, Lund University, Skåne University Hospital, Malmö, SwedenBackground: The purpose of this study was to evaluate the visual outcome and self-reported vision-targeted health status in patients treated with intravitreal ranibizumab for wet age-related macular degeneration (AMD).Methods: A total of 51 eyes from 50 patients aged 76 ± 7 years, with wet AMD not previously treated, were included in this prospective study. Best corrected visual acuity was examined using Early Treatment Diabetic Research Study charts and near vision reading. All patients underwent an ophthalmological examination, including fluorescein and indocyanine green angiography (occult cases) and optical coherence tomography. The Visual Function Questionnaire test was completed before and 37 ± 7 months after the start of intravitreal injections.Results: The patients received a mean number of 7.8 ± 5.0 (range 2–22) injections. One month after the third intravitreal injection, significant improvement was seen in both visual acuity (53 ± 14 to 61 ± 14 letter, P = 0.001) and near vision (17 ± 9 to 11 ± 8 points, P = 0.001). During follow-up, mean visual acuity decreased from 53 ± 14 to 44 ± 24 letters (P = 0.011), and near vision decreased from 17 ± 9 to 20 ± 11 points (P = 0.048). Despite visual impairment, the quality of life test revealed no significant decrease in mental health (P = 0.529) or ability to read a newspaper (P = 0.21), but a decrease in distance activities (reading street signs, steps, going to the theater) from 57 ± 27 to 46 ± 31 points (P = 0.007) was documented.Conclusion: Decreased visual acuity was related to a decrease in self-reported visual function for distance activities, while mental health items, such as worrying, were not influenced.Keywords: visual outcome, quality of life, age-related macular degenerationRung LLövestam-Adrian MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 395-401 (2013)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Rung L
Lövestam-Adrian M
Three-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration
description Lena Rung,1 Monica Lövestam-Adrian21Department of Ophthalmology, Helsingborg Hospital, Helsingborg, 2Department of Ophthalmology, Lund University, Skåne University Hospital, Malmö, SwedenBackground: The purpose of this study was to evaluate the visual outcome and self-reported vision-targeted health status in patients treated with intravitreal ranibizumab for wet age-related macular degeneration (AMD).Methods: A total of 51 eyes from 50 patients aged 76 ± 7 years, with wet AMD not previously treated, were included in this prospective study. Best corrected visual acuity was examined using Early Treatment Diabetic Research Study charts and near vision reading. All patients underwent an ophthalmological examination, including fluorescein and indocyanine green angiography (occult cases) and optical coherence tomography. The Visual Function Questionnaire test was completed before and 37 ± 7 months after the start of intravitreal injections.Results: The patients received a mean number of 7.8 ± 5.0 (range 2–22) injections. One month after the third intravitreal injection, significant improvement was seen in both visual acuity (53 ± 14 to 61 ± 14 letter, P = 0.001) and near vision (17 ± 9 to 11 ± 8 points, P = 0.001). During follow-up, mean visual acuity decreased from 53 ± 14 to 44 ± 24 letters (P = 0.011), and near vision decreased from 17 ± 9 to 20 ± 11 points (P = 0.048). Despite visual impairment, the quality of life test revealed no significant decrease in mental health (P = 0.529) or ability to read a newspaper (P = 0.21), but a decrease in distance activities (reading street signs, steps, going to the theater) from 57 ± 27 to 46 ± 31 points (P = 0.007) was documented.Conclusion: Decreased visual acuity was related to a decrease in self-reported visual function for distance activities, while mental health items, such as worrying, were not influenced.Keywords: visual outcome, quality of life, age-related macular degeneration
format article
author Rung L
Lövestam-Adrian M
author_facet Rung L
Lövestam-Adrian M
author_sort Rung L
title Three-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration
title_short Three-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration
title_full Three-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration
title_fullStr Three-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration
title_full_unstemmed Three-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration
title_sort three-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/79aca22bb5204b1db10fa4db528d364a
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AT lampoumlvestamadrianm threeyearfollowupofvisualoutcomeandqualityoflifeinpatientswithagerelatedmaculardegeneration
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