A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination
BRCA2 plays a central role in facilitating DNA repair by homologous recombination (HR). Here the authors describe how BRCA2 forms a complex with the protein phosphatase PP2A-B56 in response to DNA damage, which is required for HR.
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Nature Portfolio
2021
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oai:doaj.org-article:79b0e8134f2045ccac494a8dddce3e542021-12-02T17:18:32ZA complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination10.1038/s41467-021-26079-02041-1723https://doaj.org/article/79b0e8134f2045ccac494a8dddce3e542021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26079-0https://doaj.org/toc/2041-1723BRCA2 plays a central role in facilitating DNA repair by homologous recombination (HR). Here the authors describe how BRCA2 forms a complex with the protein phosphatase PP2A-B56 in response to DNA damage, which is required for HR.Sara M. AmbjørnJulien P. DuxinEmil P. T. HertzIsha NasaJoana DuroThomas KruseBlanca Lopez-MendezBeata RymarczykLauren E. CresseyThomas van Overeem HansenArminja N. KettenbachVibe H. OestergaardMichael LisbyJakob NilssonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sara M. Ambjørn Julien P. Duxin Emil P. T. Hertz Isha Nasa Joana Duro Thomas Kruse Blanca Lopez-Mendez Beata Rymarczyk Lauren E. Cressey Thomas van Overeem Hansen Arminja N. Kettenbach Vibe H. Oestergaard Michael Lisby Jakob Nilsson A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination |
| description |
BRCA2 plays a central role in facilitating DNA repair by homologous recombination (HR). Here the authors describe how BRCA2 forms a complex with the protein phosphatase PP2A-B56 in response to DNA damage, which is required for HR. |
| format |
article |
| author |
Sara M. Ambjørn Julien P. Duxin Emil P. T. Hertz Isha Nasa Joana Duro Thomas Kruse Blanca Lopez-Mendez Beata Rymarczyk Lauren E. Cressey Thomas van Overeem Hansen Arminja N. Kettenbach Vibe H. Oestergaard Michael Lisby Jakob Nilsson |
| author_facet |
Sara M. Ambjørn Julien P. Duxin Emil P. T. Hertz Isha Nasa Joana Duro Thomas Kruse Blanca Lopez-Mendez Beata Rymarczyk Lauren E. Cressey Thomas van Overeem Hansen Arminja N. Kettenbach Vibe H. Oestergaard Michael Lisby Jakob Nilsson |
| author_sort |
Sara M. Ambjørn |
| title |
A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination |
| title_short |
A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination |
| title_full |
A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination |
| title_fullStr |
A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination |
| title_full_unstemmed |
A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination |
| title_sort |
complex of brca2 and pp2a-b56 is required for dna repair by homologous recombination |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/79b0e8134f2045ccac494a8dddce3e54 |
| work_keys_str_mv |
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