Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans

Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans

How phosphorylation mediated by Insulin/IGF-1 Signaling kinases regulates lifespan remains unclear. Here the authors perform a large-scale quantitative phosphoproteomic analysis of wildtype and IIS mutant C. elegans strains to reveal detailed functional insights into longevity.

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Autores principales: Wen-Jun Li, Chen-Wei Wang, Li Tao, Yong-Hong Yan, Mei-Jun Zhang, Ze-Xian Liu, Yu-Xin Li, Han-Qing Zhao, Xue-Mei Li, Xian-Dong He, Yu Xue, Meng-Qiu Dong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/79b32e5ef67f4e64b5c54680fd9b724a
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spelling oai:doaj.org-article:79b32e5ef67f4e64b5c54680fd9b724a2021-12-02T16:24:57ZInsulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans10.1038/s41467-021-24816-z2041-1723https://doaj.org/article/79b32e5ef67f4e64b5c54680fd9b724a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24816-zhttps://doaj.org/toc/2041-1723How phosphorylation mediated by Insulin/IGF-1 Signaling kinases regulates lifespan remains unclear. Here the authors perform a large-scale quantitative phosphoproteomic analysis of wildtype and IIS mutant C. elegans strains to reveal detailed functional insights into longevity.Wen-Jun LiChen-Wei WangLi TaoYong-Hong YanMei-Jun ZhangZe-Xian LiuYu-Xin LiHan-Qing ZhaoXue-Mei LiXian-Dong HeYu XueMeng-Qiu DongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wen-Jun Li
Chen-Wei Wang
Li Tao
Yong-Hong Yan
Mei-Jun Zhang
Ze-Xian Liu
Yu-Xin Li
Han-Qing Zhao
Xue-Mei Li
Xian-Dong He
Yu Xue
Meng-Qiu Dong
Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
description How phosphorylation mediated by Insulin/IGF-1 Signaling kinases regulates lifespan remains unclear. Here the authors perform a large-scale quantitative phosphoproteomic analysis of wildtype and IIS mutant C. elegans strains to reveal detailed functional insights into longevity.
format article
author Wen-Jun Li
Chen-Wei Wang
Li Tao
Yong-Hong Yan
Mei-Jun Zhang
Ze-Xian Liu
Yu-Xin Li
Han-Qing Zhao
Xue-Mei Li
Xian-Dong He
Yu Xue
Meng-Qiu Dong
author_facet Wen-Jun Li
Chen-Wei Wang
Li Tao
Yong-Hong Yan
Mei-Jun Zhang
Ze-Xian Liu
Yu-Xin Li
Han-Qing Zhao
Xue-Mei Li
Xian-Dong He
Yu Xue
Meng-Qiu Dong
author_sort Wen-Jun Li
title Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
title_short Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
title_full Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
title_fullStr Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
title_full_unstemmed Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
title_sort insulin signaling regulates longevity through protein phosphorylation in caenorhabditis elegans
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/79b32e5ef67f4e64b5c54680fd9b724a
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