Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor

The processes regulating cardiomyocyte (CM) maturation are unclear. Here, the authors show that serum response factor regulates CM maturation only in neonatal CMs through stage-specific chromatin occupancy that affects cell size, sarcomere and transverse-tubule organization, and mitochondria

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Autores principales:	Yuxuan Guo, Blake D. Jardin, Pingzhu Zhou, Isha Sethi, Brynn N. Akerberg, Christopher N Toepfer, Yulan Ai, Yifei Li, Qing Ma, Silvia Guatimosim, Yongwu Hu, Grigor Varuzhanyan, Nathan J. VanDusen, Donghui Zhang, David C. Chan, Guo-Cheng Yuan, Christine E. Seidman, Jonathan G. Seidman, William T. Pu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79b67194c3e44f45957af9c4b8ff1945
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spelling	oai:doaj.org-article:79b67194c3e44f45957af9c4b8ff19452021-12-02T17:31:47ZHierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor10.1038/s41467-018-06347-22041-1723https://doaj.org/article/79b67194c3e44f45957af9c4b8ff19452018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06347-2https://doaj.org/toc/2041-1723The processes regulating cardiomyocyte (CM) maturation are unclear. Here, the authors show that serum response factor regulates CM maturation only in neonatal CMs through stage-specific chromatin occupancy that affects cell size, sarcomere and transverse-tubule organization, and mitochondriaYuxuan GuoBlake D. JardinPingzhu ZhouIsha SethiBrynn N. AkerbergChristopher N ToepferYulan AiYifei LiQing MaSilvia GuatimosimYongwu HuGrigor VaruzhanyanNathan J. VanDusenDonghui ZhangDavid C. ChanGuo-Cheng YuanChristine E. SeidmanJonathan G. SeidmanWilliam T. PuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuxuan Guo Blake D. Jardin Pingzhu Zhou Isha Sethi Brynn N. Akerberg Christopher N Toepfer Yulan Ai Yifei Li Qing Ma Silvia Guatimosim Yongwu Hu Grigor Varuzhanyan Nathan J. VanDusen Donghui Zhang David C. Chan Guo-Cheng Yuan Christine E. Seidman Jonathan G. Seidman William T. Pu Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor
description	The processes regulating cardiomyocyte (CM) maturation are unclear. Here, the authors show that serum response factor regulates CM maturation only in neonatal CMs through stage-specific chromatin occupancy that affects cell size, sarcomere and transverse-tubule organization, and mitochondria
format	article
author	Yuxuan Guo Blake D. Jardin Pingzhu Zhou Isha Sethi Brynn N. Akerberg Christopher N Toepfer Yulan Ai Yifei Li Qing Ma Silvia Guatimosim Yongwu Hu Grigor Varuzhanyan Nathan J. VanDusen Donghui Zhang David C. Chan Guo-Cheng Yuan Christine E. Seidman Jonathan G. Seidman William T. Pu
author_facet	Yuxuan Guo Blake D. Jardin Pingzhu Zhou Isha Sethi Brynn N. Akerberg Christopher N Toepfer Yulan Ai Yifei Li Qing Ma Silvia Guatimosim Yongwu Hu Grigor Varuzhanyan Nathan J. VanDusen Donghui Zhang David C. Chan Guo-Cheng Yuan Christine E. Seidman Jonathan G. Seidman William T. Pu
author_sort	Yuxuan Guo
title	Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor
title_short	Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor
title_full	Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor
title_fullStr	Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor
title_full_unstemmed	Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor
title_sort	hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/79b67194c3e44f45957af9c4b8ff1945
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Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor

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