Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis

Epithelial cancer cells can transition into a mesenchymal phenotype to enable invasion and metastasis. Here, the authors use previously published single-cell and bulk RNA sequencing datasets to decouple the mesenchymal expression profiles of cancer and stromal cells.

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Detalles Bibliográficos
Autores principales: Michael Tyler, Itay Tirosh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/79b957e782e7477892adcf1d678e5839
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Descripción
Sumario:Epithelial cancer cells can transition into a mesenchymal phenotype to enable invasion and metastasis. Here, the authors use previously published single-cell and bulk RNA sequencing datasets to decouple the mesenchymal expression profiles of cancer and stromal cells.