Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis

Epithelial cancer cells can transition into a mesenchymal phenotype to enable invasion and metastasis. Here, the authors use previously published single-cell and bulk RNA sequencing datasets to decouple the mesenchymal expression profiles of cancer and stromal cells.

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Detalles Bibliográficos
Autores principales:	Michael Tyler, Itay Tirosh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79b957e782e7477892adcf1d678e5839
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spelling	oai:doaj.org-article:79b957e782e7477892adcf1d678e58392021-12-02T17:02:04ZDecoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis10.1038/s41467-021-22800-12041-1723https://doaj.org/article/79b957e782e7477892adcf1d678e58392021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22800-1https://doaj.org/toc/2041-1723Epithelial cancer cells can transition into a mesenchymal phenotype to enable invasion and metastasis. Here, the authors use previously published single-cell and bulk RNA sequencing datasets to decouple the mesenchymal expression profiles of cancer and stromal cells.Michael TylerItay TiroshNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Tyler Itay Tirosh Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
description	Epithelial cancer cells can transition into a mesenchymal phenotype to enable invasion and metastasis. Here, the authors use previously published single-cell and bulk RNA sequencing datasets to decouple the mesenchymal expression profiles of cancer and stromal cells.
format	article
author	Michael Tyler Itay Tirosh
author_facet	Michael Tyler Itay Tirosh
author_sort	Michael Tyler
title	Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
title_short	Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
title_full	Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
title_fullStr	Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
title_full_unstemmed	Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
title_sort	decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/79b957e782e7477892adcf1d678e5839
work_keys_str_mv	AT michaeltyler decouplingepithelialmesenchymaltransitionsfromstromalprofilesbyintegrativeexpressionanalysis AT itaytirosh decouplingepithelialmesenchymaltransitionsfromstromalprofilesbyintegrativeexpressionanalysis
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Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis

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