Novelties in etiopathogenesis, diagnosis and treatment of patients with lumbar intevrertebral disc degeneration
. Low-back pain is one of the most common causes of physical disability, most often originating from intervertebral disc degeneration. Lack of pinpointing the exact source of pain is the limiting factor in more efficient prevention and treatment. New findings, especially in the fields of genetics...
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Hrvatski liječnički zbor
2021
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oai:doaj.org-article:79bb3998f0104981a6a9939d677bff8d2021-12-01T14:00:29ZNovelties in etiopathogenesis, diagnosis and treatment of patients with lumbar intevrertebral disc degeneration10.26800/LV-143-1-2-90024-34771849-2177https://doaj.org/article/79bb3998f0104981a6a9939d677bff8d2021-02-01T00:00:00Zhttps://lijecnicki-vjesnik.hlz.hr/lijecnicki-vjesnik/novosti-u-etiopatogenezi-dijagnostici-i-lijecenju-bolesnika-s-degenerativnim-promjenama-intervertebralnog-diska-slabinskog-dijela-kraljeznice/https://doaj.org/toc/0024-3477https://doaj.org/toc/1849-2177. Low-back pain is one of the most common causes of physical disability, most often originating from intervertebral disc degeneration. Lack of pinpointing the exact source of pain is the limiting factor in more efficient prevention and treatment. New findings, especially in the fields of genetics and mass spectometry based protein analysis, shed a new light to the understanding of etiopathogenesis of disc degenerative disease. New imaging methods like chemical exchange saturation transfer (CEST)MRI or apparent diffusion coefficient (ADC)MRI can detect early degenerative changes. Advances have been made regarding elucidating the role of physical load, as well as the type of exercise that can have an impact on the development and treatment of patients with degenerative disc disease. Finally, a significant progress has been made in the surgical treatment ecouraging of these patients, with an emphasis on minimally invasive techniques. Other surgical modalities have also shown improvement, like total disc replacement and mesenchymal stem cells treatments. These, and other novelties in the diagnosis and treatment of degenerative disc disease of lumbar spine are discussed in this article.Simeon GrazioLovorka GrgurevićDarko PerovićTea Schnurrer Luke VrbanićZdenko KovačBoris BožićKarlo Houra Igor BorićDražen KvesićRuđer NovakLejla Ferhatović HamzićFrane GrubišićTomislav SajkoRobert SaftićStjepan DokuzovićKrešimir RotimHrvatski liječnički zborarticleintervertebral disc degeneration – complicationsdiagnostic imagingetiologyphysiopathologysurgery; low back pain – etiologytherapy; lumbar vertebrae – surgery; intervertebral disc displacement – complicationsMedicine (General)R5-920ENHRLiječnički vjesnik, Vol 143, Iss 1-2, Pp 63-77 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN HR |
| topic |
intervertebral disc degeneration – complications diagnostic imaging etiology physiopathology surgery; low back pain – etiology therapy; lumbar vertebrae – surgery; intervertebral disc displacement – complications Medicine (General) R5-920 |
| spellingShingle |
intervertebral disc degeneration – complications diagnostic imaging etiology physiopathology surgery; low back pain – etiology therapy; lumbar vertebrae – surgery; intervertebral disc displacement – complications Medicine (General) R5-920 Simeon Grazio Lovorka Grgurević Darko Perović Tea Schnurrer Luke Vrbanić Zdenko Kovač Boris Božić Karlo Houra Igor Borić Dražen Kvesić Ruđer Novak Lejla Ferhatović Hamzić Frane Grubišić Tomislav Sajko Robert Saftić Stjepan Dokuzović Krešimir Rotim Novelties in etiopathogenesis, diagnosis and treatment of patients with lumbar intevrertebral disc degeneration |
| description |
. Low-back pain is one of the most common causes of physical disability, most often originating from
intervertebral disc degeneration. Lack of pinpointing the exact source of pain is the limiting factor in more efficient
prevention and treatment. New findings, especially in the fields of genetics and mass spectometry based protein
analysis, shed a new light to the understanding of etiopathogenesis of disc degenerative disease. New imaging
methods like chemical exchange saturation transfer (CEST)MRI or apparent diffusion coefficient (ADC)MRI can
detect early degenerative changes. Advances have been made regarding elucidating the role of physical load, as
well as the type of exercise that can have an impact on the development and treatment of patients with degenerative disc disease. Finally, a significant progress has been made in the surgical treatment ecouraging of these
patients, with an emphasis on minimally invasive techniques. Other surgical modalities have also shown improvement, like total disc replacement and mesenchymal stem cells treatments. These, and other novelties in the diagnosis and treatment of degenerative disc disease of lumbar spine are discussed in this article. |
| format |
article |
| author |
Simeon Grazio Lovorka Grgurević Darko Perović Tea Schnurrer Luke Vrbanić Zdenko Kovač Boris Božić Karlo Houra Igor Borić Dražen Kvesić Ruđer Novak Lejla Ferhatović Hamzić Frane Grubišić Tomislav Sajko Robert Saftić Stjepan Dokuzović Krešimir Rotim |
| author_facet |
Simeon Grazio Lovorka Grgurević Darko Perović Tea Schnurrer Luke Vrbanić Zdenko Kovač Boris Božić Karlo Houra Igor Borić Dražen Kvesić Ruđer Novak Lejla Ferhatović Hamzić Frane Grubišić Tomislav Sajko Robert Saftić Stjepan Dokuzović Krešimir Rotim |
| author_sort |
Simeon Grazio |
| title |
Novelties in etiopathogenesis, diagnosis and treatment of patients with lumbar intevrertebral disc degeneration |
| title_short |
Novelties in etiopathogenesis, diagnosis and treatment of patients with lumbar intevrertebral disc degeneration |
| title_full |
Novelties in etiopathogenesis, diagnosis and treatment of patients with lumbar intevrertebral disc degeneration |
| title_fullStr |
Novelties in etiopathogenesis, diagnosis and treatment of patients with lumbar intevrertebral disc degeneration |
| title_full_unstemmed |
Novelties in etiopathogenesis, diagnosis and treatment of patients with lumbar intevrertebral disc degeneration |
| title_sort |
novelties in etiopathogenesis, diagnosis and treatment of patients with lumbar intevrertebral disc degeneration |
| publisher |
Hrvatski liječnički zbor |
| publishDate |
2021 |
| url |
https://doaj.org/article/79bb3998f0104981a6a9939d677bff8d |
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| _version_ |
1718405067251384320 |