Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis

Whipple’s Disease is a rare systemic infectious disease caused by the ubiquitous actinomycetes <i>Tropheryma whipplei (T. whipplei).</i> We report herein a rare case of a cutaneous granulo matosis with hypercalcemia as an unusual presenting feature of Whipple’s disease. The diagnosis of...

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Autores principales:	Souheil Zayet, Pierre Isnard, Jacinta Bustamante, David Boutboul, Sarra Abroug, Nabil Belfeki
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	granulomatosis polymerase chain reaction skin Whipple’s disease <i>Tropheryma whipplei</i> Medicine R
Acceso en línea:	https://doaj.org/article/79bbc827868243a6926c4667e23e1e67
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id	oai:doaj.org-article:79bbc827868243a6926c4667e23e1e67
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spelling	oai:doaj.org-article:79bbc827868243a6926c4667e23e1e672021-11-25T18:38:15ZCutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis10.3390/pathogens101114382076-0817https://doaj.org/article/79bbc827868243a6926c4667e23e1e672021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1438https://doaj.org/toc/2076-0817Whipple’s Disease is a rare systemic infectious disease caused by the ubiquitous actinomycetes <i>Tropheryma whipplei (T. whipplei).</i> We report herein a rare case of a cutaneous granulo matosis with hypercalcemia as an unusual presenting feature of Whipple’s disease. The diagnosis of the bacteria was obtained from skin and inguinal lymph node biopsy (16 rDNA PCR screening and histological examination using PAS staining). <i>T. whipplei</i> was also identified on saliva and stool specimens, using specific PCR and colonic biopsies. Treatment with hydroxychloroquine and doxycycline allowed a rapid resolution of symptoms with a complete recovery.Souheil ZayetPierre IsnardJacinta BustamanteDavid BoutboulSarra AbrougNabil BelfekiMDPI AGarticlegranulomatosispolymerase chain reactionskinWhipple’s disease<i>Tropheryma whipplei</i>MedicineRENPathogens, Vol 10, Iss 1438, p 1438 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	granulomatosis polymerase chain reaction skin Whipple’s disease <i>Tropheryma whipplei</i> Medicine R
spellingShingle	granulomatosis polymerase chain reaction skin Whipple’s disease <i>Tropheryma whipplei</i> Medicine R Souheil Zayet Pierre Isnard Jacinta Bustamante David Boutboul Sarra Abroug Nabil Belfeki Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis
description	Whipple’s Disease is a rare systemic infectious disease caused by the ubiquitous actinomycetes <i>Tropheryma whipplei (T. whipplei).</i> We report herein a rare case of a cutaneous granulo matosis with hypercalcemia as an unusual presenting feature of Whipple’s disease. The diagnosis of the bacteria was obtained from skin and inguinal lymph node biopsy (16 rDNA PCR screening and histological examination using PAS staining). <i>T. whipplei</i> was also identified on saliva and stool specimens, using specific PCR and colonic biopsies. Treatment with hydroxychloroquine and doxycycline allowed a rapid resolution of symptoms with a complete recovery.
format	article
author	Souheil Zayet Pierre Isnard Jacinta Bustamante David Boutboul Sarra Abroug Nabil Belfeki
author_facet	Souheil Zayet Pierre Isnard Jacinta Bustamante David Boutboul Sarra Abroug Nabil Belfeki
author_sort	Souheil Zayet
title	Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis
title_short	Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis
title_full	Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis
title_fullStr	Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis
title_full_unstemmed	Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis
title_sort	cutaneous granulomatosis revealing whipple’s disease: value of <i>tropheryma whipplei</i> polymerase chain reaction assay for the diagnosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/79bbc827868243a6926c4667e23e1e67
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Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis

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