Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

Yosra SR Elnaggar Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt Abstract: The human body has long provided pharmaceutical science with biomaterials of interesting applications. Bile salts (BSs) are biomaterials reminiscent of traditional surfactants wit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Elnaggar YS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/79bce39de865463bb9df6e3aa4f0a5b6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:79bce39de865463bb9df6e3aa4f0a5b6
record_format	dspace
spelling	oai:doaj.org-article:79bce39de865463bb9df6e3aa4f0a5b62021-12-02T04:28:15ZMultifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine1178-2013https://doaj.org/article/79bce39de865463bb9df6e3aa4f0a5b62015-06-01T00:00:00Zhttp://www.dovepress.com/multifaceted-applications-of-bile-salts-in-pharmacy-an-emphasis-on-nan-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yosra SR Elnaggar Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt Abstract: The human body has long provided pharmaceutical science with biomaterials of interesting applications. Bile salts (BSs) are biomaterials reminiscent of traditional surfactants with peculiar structure and self-assembled topologies. In the pharmaceutical field, BSs were employed on the basis of two different concepts. The first concept exploited BSs’ metabolic and homeostatic functions in disease modulation, whereas the second one utilized BSs’ potential to modify drug-delivery characteristics, which recently involved nanotechnology. This review is the first to gather major pharmaceutical applications of BSs from endogenous organotropism up to integration into nanomedicine, with a greater focus on the latter domain. Endogenous applications highlighted the role of BS in modulating hypercholesterolemia and cancer therapy in view of enterohepatic circulation. In addition, recent BS-integrated nanomedicines have been surveyed, chiefly size-tunable cholate nanoparticles, BS-lecithin mixed micelles, bilosomes, probilosomes, and surface-engineered bilosomes. A greater emphasis has been laid on nanosystems for vaccine and cancer therapy. The comparative advantages of BS-integrated nanomedicines over conventional nanocarriers have been noted. Paradoxical effects, current pitfalls, future perspectives, and opinions have also been outlined. Keywords: bile salt, nanomedicine, bilosomes, liposomes, size-tunable nanoparticles Elnaggar YSDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3955-3971 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Elnaggar YS Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine
description	Yosra SR Elnaggar Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt Abstract: The human body has long provided pharmaceutical science with biomaterials of interesting applications. Bile salts (BSs) are biomaterials reminiscent of traditional surfactants with peculiar structure and self-assembled topologies. In the pharmaceutical field, BSs were employed on the basis of two different concepts. The first concept exploited BSs’ metabolic and homeostatic functions in disease modulation, whereas the second one utilized BSs’ potential to modify drug-delivery characteristics, which recently involved nanotechnology. This review is the first to gather major pharmaceutical applications of BSs from endogenous organotropism up to integration into nanomedicine, with a greater focus on the latter domain. Endogenous applications highlighted the role of BS in modulating hypercholesterolemia and cancer therapy in view of enterohepatic circulation. In addition, recent BS-integrated nanomedicines have been surveyed, chiefly size-tunable cholate nanoparticles, BS-lecithin mixed micelles, bilosomes, probilosomes, and surface-engineered bilosomes. A greater emphasis has been laid on nanosystems for vaccine and cancer therapy. The comparative advantages of BS-integrated nanomedicines over conventional nanocarriers have been noted. Paradoxical effects, current pitfalls, future perspectives, and opinions have also been outlined. Keywords: bile salt, nanomedicine, bilosomes, liposomes, size-tunable nanoparticles
format	article
author	Elnaggar YS
author_facet	Elnaggar YS
author_sort	Elnaggar YS
title	Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine
title_short	Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine
title_full	Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine
title_fullStr	Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine
title_full_unstemmed	Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine
title_sort	multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/79bce39de865463bb9df6e3aa4f0a5b6
work_keys_str_mv	AT elnaggarys multifacetedapplicationsofbilesaltsinpharmacyanemphasisonnanomedicine
_version_	1718401193942712320

Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

Ejemplares similares